Reactions of the isolated plaice stomach to applied drugs

Edwards, Deborah A

doi:10.1016/0010-4035(72)90014-6

Cited by 24 publications

(6 citation statements)

References 23 publications

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“…The PA,-values compare well with those obtained in experiments with tissues from other teleosts and from mammals (Schild 1947, van Rossum 1963, Edwards 1972, Holmgren and Nilsson 1975.…”

Section: Discussionsupporting

confidence: 83%

Autonomic Nerve Control of the Swimbladder of the Goldsinny Wrasse, Ctenolabrus rupestris

Fänge

Holmgren

Nilsson

1976

Acta Physiologica Scandinavica

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The autonomic nerve control of the swimbladder of the goldsinny wrasse has been studied by experiments with isolated strips from the muscularis mucosae, drug effects on gas secretion in vivo, fluorescent histochemistry and quantitative analysis of catecholamine content. Vagotomy, atropine and mecamylamine significantly inhibited induced gas secretion, suggesting a cholinergic vagal secretory innervation of the gas gland. The anterior part of the mucosa (secretory part) is contracted by acetylcholine and alpha-adrenoceptor agonists. These responses are competitively antagonized by atropine and phentolamine or yohimbine respectively. The posterior (resorbent) part of the mucosa is contracted by acetylcholine, but beta-adrenoceptor agonists relax the acetylcholine-precontracted preparations. These responses are competitively blocked by atropine and propranolol respectively. The pA2-values from all experiments with antagonists are well comparable with values obtained for the same drugs in other teleost or mammalian tissues. Tyramine, 5-hydroxytryptamine or phenylephrine had mixed effects on the posterior part. This effect is at least in part due to release of nervously stored catecholamines. Fluorescent histochemistry revealed a strong innervation by both smooth and varicose adrenergic fibres in all parts of the swimbladder, noradrenaline being the dominant catecholamine. Yellow fluorescent cells, which may contain 5-hydroxytryptamine, were also seen in the swimbladder mucosa. No conclusive evidence for a cholinergic innervation of the muscularis mucosae was obtained.

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“…The PA,-values compare well with those obtained in experiments with tissues from other teleosts and from mammals (Schild 1947, van Rossum 1963, Edwards 1972, Holmgren and Nilsson 1975.…”

Section: Discussionsupporting

confidence: 83%

Autonomic Nerve Control of the Swimbladder of the Goldsinny Wrasse, Ctenolabrus rupestris

Fänge

Holmgren

Nilsson

1976

Acta Physiologica Scandinavica

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“…Also in another teleost, the plaice Pleuronectes phtessu, cholinergically induced contraction of the stomach was found to be mediated by muscarinic receptors (Edwards 1972). This decrease was most likely due to contraction of the stomach following activation of the muscarinic receptors demonstrated by Nilsson and Fange (1 969).…”

Section: Discussionmentioning

confidence: 91%

Effect of the H₂‐Receptor Antagonist Metiamide on Carbachol‐and Histamine‐Induced Gastric Acid Secretion in the Atlantic Cod, Gadus morhua

Holstein

1976

Acta Physiologica Scandinavica

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Gastric acid secretion was measured in swimming codfish surgically equipped with a catheter draining the stomach. Intramuscular injection of histamine (15.6 mug/kg-h) or carbachol (5 mug/kg-h) stimulated the secretion of acid, carbachol in addition caused a marked decrease in drinking rate of the fishes. Administration of 10 mumol/kg-h metiamide completely prevented the acid secretion induced by both drugs. The carbachol effect on the drinking rate, interpreted to mirror contraction of the stomach following stimulation of muscarinic receptors, was not affected by metiamide.

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“…Noradrenaline or adrenaline cause contraction of smooth muscle of the gastrointestinal tract of some species of teleost fish (Burnstock, 1958;Nilsson & Fange, 1967;1969;Edwards, 1972;Campbell & Gannon, 1976). Electrical stimulation of the vagus nerve of the cod (Nilsson & Finge, 1969) or of the splanchnic nerve of the rainbow trout (Campbell & Gannon, 1976) causes contraction of gastric smooth muscle, an effect which is inhibited by the adrenergic neurone blocking agent, bretylium.…”

Section: Introductionmentioning

confidence: 99%

α₂‐Adrenoceptor‐mediated contractile response to catecholamines in smooth muscle strips isolated from rainbow trout stomach (Salmo gairdneri)

Kitazawa

Kondo

Temma

1986

British J Pharmacology

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1The type of adrenoceptor involved in the contractile response to catecholamines in smooth muscle strips isolated from rainbow trout stomach was determined.2 Noradrenaline (10 nM-10 ptM) and adrenaline (10 nM-3 pM) caused non-sustained contractions which were markedly decreased by phentolamine (5.4 pM) but not by carteolol (5 PM). Phenylephrine(1 jiM -1 mM) was less effective in causing muscle contraction and methoxamine produced no contraction. Clonidine (100 nM-300JM) caused no mechanical response but inhibited the contraction to noradrenaline or adrenaline but not acetylcholine or 5-hydroxytryptamine. 3 Yohimbine (10nM-1 pM) decreased the contraction induced by noradrenaline or adrenaline but prazosin (1 piM) did not. 4 Tetrodotoxin (780 nM) partially reduced the contraction induced by noradrenaline or adrenaline but atropine (500 nM) did not. 5 In the presence of atropine (1 pM), electrical transmural stimulation caused frequency-dependent, tetrodotoxin-sensitive contractions. 6 These results suggest that the contractile response induced by noradrenaline or adrenaline is mediated by M2-adrenoceptors. It is also suggested that noradrenaline and adrenaline contract the smooth muscle by direct action and by indirect action through the non-cholinergic excitatory nerve.

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Reactions of the isolated plaice stomach to applied drugs

Cited by 24 publications

References 23 publications

Autonomic Nerve Control of the Swimbladder of the Goldsinny Wrasse, Ctenolabrus rupestris

Autonomic Nerve Control of the Swimbladder of the Goldsinny Wrasse, Ctenolabrus rupestris

Effect of the H₂‐Receptor Antagonist Metiamide on Carbachol‐and Histamine‐Induced Gastric Acid Secretion in the Atlantic Cod, Gadus morhua

α₂‐Adrenoceptor‐mediated contractile response to catecholamines in smooth muscle strips isolated from rainbow trout stomach (Salmo gairdneri)

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Reactions of the isolated plaice stomach to applied drugs

Cited by 24 publications

References 23 publications

Autonomic Nerve Control of the Swimbladder of the Goldsinny Wrasse, Ctenolabrus rupestris

Autonomic Nerve Control of the Swimbladder of the Goldsinny Wrasse, Ctenolabrus rupestris

Effect of the H2‐Receptor Antagonist Metiamide on Carbachol‐and Histamine‐Induced Gastric Acid Secretion in the Atlantic Cod, Gadus morhua

α2‐Adrenoceptor‐mediated contractile response to catecholamines in smooth muscle strips isolated from rainbow trout stomach (Salmo gairdneri)

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Effect of the H₂‐Receptor Antagonist Metiamide on Carbachol‐and Histamine‐Induced Gastric Acid Secretion in the Atlantic Cod, Gadus morhua

α₂‐Adrenoceptor‐mediated contractile response to catecholamines in smooth muscle strips isolated from rainbow trout stomach (Salmo gairdneri)