Reactions of trans-[Pt(15NH3)2(H2O)2]2+ with Glutathione

Abstract

A study of the reaction between trans-[Pt(15 NH 3 ) 2 (H 2 O) 2 ](NO 3 ) 2 and glutathione (GSH) was undertaken to confirm the identity of the products formed. In alkaline solution, the platinum products observed were mononuclear species, while in acidic solution, the oligomeric products were products obtained. The mass spectrometry of the reaction in alkaline solution showed a sulfur-bridged dinuclear platinum(II) species, trans-[{Pt(SG) 2 ( 15 NH 3 ) 2 } 2 (SG)] + giving m/z 1380 and the lost of two ammines was observed.