Reactions on Polymer Supports

Chemical synthesis of a gene for human epidermal growth factor urogastrone and its expression in yeast.

“…Letsinger and co-workers (25,26) showed that phosphite triester intermediates could be used to synthesize oligodeoxyribonucleotides, thereby greatly increasing the rate and ease of the coupling procedure. Several groups have used solidphase-supported nucleosides in oligonucleotide synthesis (27)(28)(29), and this has been adapted to phosphite triester chemistry (30)(31)(32). A significant problem incurred in the phosphite method has been the chemical lability of the phosphorochloridite intermediates initially investigated.…”

The use of polymer supports in organic synthesis. VIII. Solid phase syntheses of insect sex attractants

“…Thus one would expect the synthesis of a natural product in eight different steps to be considerably more difficult than that of a pentapeptide involving eight steps but only two different steps. Syntheses of natural products, in general, have not been attempted on solid phases despite the inherent advantages of this method (1,2,5), possibly due to the fact that each reaction in the synthetic scheme must be carefully examined with respect to its compatibility with the heterogeneous reaction medium, even though the given reaction under investigation was highly successful in homogeneous phase.…”

Efficient Polymer‐Supported Pd Catalysts for the Heck Reaction

“…[54][55][56] The Schiff-bases were prepared by the reaction of the formylated poly(styrene-divinylbenzene) and different amines. A great excess of amines were used.…”

“…The formylation of poly(styrene-divinylbenzene) and the acetylation of poly(styrene-divinylbenzene) were performed as previously described in literature. [54][55][56] The disappearance of absorption at 1265 cm -1 for the C-Cl bonds of the Merrifield resin and a strong absorption band at 1698 cm -1 for the carbonyl group indicate that the chloromethylated polymer was successfully oxidized to the corresponding formylated polymer. The strong absorption band at 1682 cm -1 of the acetylated polystyrene gives a signal of successful acetylation.…”