Reactions to Amputation: Recognition and Treatment

Bhuvaneswar, Chaya G.; Epstein, Lucy A.; Stern, Theodore A.

doi:10.4088/pcc.v09n0408

Cited by 84 publications

(61 citation statements)

References 41 publications

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“…The odds of developing depression among those who undergo amputation were 3.64 times higher as compared to those who didn't undergo amputation. This may be attributed to adjustment reactions to the new event and lose of sense of independence and having to rely on others for some of the most common everyday needs after losing of one or more limbs [34], because victims may come up with difficulties in carry out daily activities as well as other tasks and it affects their recovery after orthopedic injury. This may result in increased chance of physical and psychological disabilities which are major causes of emotional distress [1,34,35].…”

Section: Discussion On Factors Associated With Depression and Anxietymentioning

confidence: 99%

“…This may be attributed to adjustment reactions to the new event and lose of sense of independence and having to rely on others for some of the most common everyday needs after losing of one or more limbs [34], because victims may come up with difficulties in carry out daily activities as well as other tasks and it affects their recovery after orthopedic injury. This may result in increased chance of physical and psychological disabilities which are major causes of emotional distress [1,34,35]. This may also be due to the fact that distortion of the patients' body image and decreased self-esteem after amputation which sets a series of emotional, perceptual and psychological reactions [36].…”

Section: Discussion On Factors Associated With Depression and Anxietymentioning

confidence: 99%

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Prevalence of Depression and Anxiety and Associated Factors among Patients Visiting Orthopedic Outpatient Clinic at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia, 2017

Srahbzu¹,

Yigizaw²,

Fanta³

et al. 2018

J Psychiatry

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Introduction:Orthopedic Trauma exerts a holistic influence on survivors' physical health including a range of mental health problems which interfere with survivors' recovery. Psychiatric disorders and behavioral disturbances are reported to be 3-5 times more common among people with injuries and are predictor of poor outcome and ongoing disability. Therefore, assessing depression and anxiety among orthopedic trauma patients play a vital role in implementing further interventions. Methods:Institutional based cross-sectional study was conducted at Tikur Anbessa specialized hospital from May 29-June 30, 2017. Hospital anxiety and depression scale was used to assess anxiety and depression by using face to face interview. Systematic sampling technique was used to select a total of 407 participants. Data has been analyzed using SPSS 20. Bivariate and multivariate logistic regression was done to identify associated factors. Variables with p-value <0.05 have been considered as statistically significant.Result: Prevalence of depression and anxiety were 36.1% and 39.8% respectively. Being female (AOR=2.3595%CI (1.48,3.72)), poor social support (AOR=2.5195%CI (1.30,4.85)), developing complication (AOR=1.9195%CI (1.07,3.52)), presence of amputation (AOR=3 .6495%CI (1.60,8.24)) and having pain (AOR=2.0295%CI (1.24,3.30)) for depression and being female (AOR=1.9995%CI(1.11,3.57)), having chronic medical illness (AOR=3.0795%CI(1.36,6.92)), having family history of mental illness (AOR=2.24 95%CI (1.05,5.4.91)), lower extremity injury (AOR=2.93 95%CI (1.38,6.21)) and having severe pain (AOR=2.75 95%CI (1.32,5.74)) for anxiety had significant association at p-value <0.05.Conclusion: prevalence of depression and anxiety were high. Being female, having poor social support, developing complication, presence of amputation and having pain for depression; and being female, having chronic medical illness, having family history of mental illness, lower extremity injury and having severe pain for anxiety were significantly associated factors. It is good if clinicians give emphasis for orthopedic patients especially for females and with chronic medical illness.

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Section: Discussion On Factors Associated With Depression and Anxietymentioning

confidence: 99%

Section: Discussion On Factors Associated With Depression and Anxietymentioning

confidence: 99%

Prevalence of Depression and Anxiety and Associated Factors among Patients Visiting Orthopedic Outpatient Clinic at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia, 2017

Srahbzu¹,

Yigizaw²,

Fanta³

et al. 2018

J Psychiatry

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“…The most stringent aspect, which triggers depressive symptomatology, is precisely the incapacity of reintegrating in pre-morbid activities [1]. Therefore, persons who made a living within mostly physical activities before the trauma adapt harder and it takes them longer to deal with the loss of a limb, compared to individuals who were sedentary before the trauma and who could resume their professional lives without great difficulties [7] [8].…”

Section: Anxiety and Depressionmentioning

confidence: 99%

Approach and Means of Support for Mental Disorders Caused by the Traumatic Amputation of a Limb

Ciubara¹,

Alexa²,

Burlea³

et al. 2015

JSS

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Amputation, one of the oldest types of surgery performed for therapeutic purposes, has main indication, the severe trauma to a limb that is incompatible to preserve because of the irreversible ischemia. The loss of a limb due to trauma has also a devastating emotional impact on a patient, escalating to genuine mental disorders that stretch out further than the loss of the limb itself produces. Thus, there is a certain sequential order regarding risk for developing mental disorders, starting from the immediate reaction, the acute stress disorder, and ending with the post-traumatic stress disorder, depression and anxiety that is mostly related to one's perceived image, which further aggravates their disability. The present paper aims to realize a synthesis of the emotional elements that can intensify up to mental disorders; by understanding the impact of squeal produced by the amputation, we can actually improve the multidisciplinary approach before and after surgery for the patient that suffered an amputation.

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“…3,7 Once a patient has undergone amputation for chronic vascular disease, including diabetes, their life expectancy is between 2 and 5 years. 8 The current standard Five-year mortality rates associated with amputation. The 5-year survival rate associated with amputation secondary to a DFU is very low compared with other common chronic diseases, such as breast and prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

NorLeu³-Angiotensin (1-7) [DSC127] as a Therapy for the Healing of Diabetic Foot Ulcers

Rodgers

Bolton

Verco

et al. 2015

Advances in Wound Care

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Diabetes is a disorder that is well known to delay wound repair resulting in the formation of colonized chronic wounds. Over their lifetime, diabetic patients have a 25% incidence of foot ulcers (DFUs), which contribute to increased risk of morbidity, including osteomyelitis and amputations, and increased burden to the healthcare system. The only active product approved for the treatment of diabetic ulcers, Regranex, is not widely used due to minimal proven efficacy and recent warnings added to the Instructions for Use. A novel topical agent that accelerates healing and increases the proportion of fully healed DFUs, DSC127 [aclerastide; active ingredient, NorLeu-angiotensin (1-7) (NorLeu-A(1-7))], is recruiting patients in Phase III clinical trials (NCT01830348 and NCT01849965). NorLeu-A(1-7) is an analog of the naturally occurring peptide, angiotensin 1-7. The mechanisms of action include induction of progenitor proliferation, accelerated vascularization, collagen deposition, and re-epithelialization. Current modalities for the treatment of DFUs include strict offloading, bandaging, debridement and, on a limited basis, application of Regranex. Novel potent therapies are needed to combat this significant burden to the diabetic patient and the healthcare system. Preclinical and clinical research shows that DSC127 is highly effective in the closure of diabetic wounds and is superior to Regranex in animal studies. Clinical development of DSC127 as a topical agent for the healing of DFU is underway. Further investigation into the mechanisms by which this product accelerates healing is warranted.

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Reactions to Amputation: Recognition and Treatment

Cited by 84 publications

References 41 publications

Prevalence of Depression and Anxiety and Associated Factors among Patients Visiting Orthopedic Outpatient Clinic at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia, 2017

Prevalence of Depression and Anxiety and Associated Factors among Patients Visiting Orthopedic Outpatient Clinic at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia, 2017

Approach and Means of Support for Mental Disorders Caused by the Traumatic Amputation of a Limb

NorLeu³-Angiotensin (1-7) [DSC127] as a Therapy for the Healing of Diabetic Foot Ulcers

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Reactions to Amputation: Recognition and Treatment

Cited by 84 publications

References 41 publications

Prevalence of Depression and Anxiety and Associated Factors among Patients Visiting Orthopedic Outpatient Clinic at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia, 2017

Prevalence of Depression and Anxiety and Associated Factors among Patients Visiting Orthopedic Outpatient Clinic at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia, 2017

Approach and Means of Support for Mental Disorders Caused by the Traumatic Amputation of a Limb

NorLeu3-Angiotensin (1-7) [DSC127] as a Therapy for the Healing of Diabetic Foot Ulcers

Contact Info

Product

Resources

About

NorLeu³-Angiotensin (1-7) [DSC127] as a Therapy for the Healing of Diabetic Foot Ulcers