Reactions to aspirin and food additives in patients with chronic urticaria, including the physical urticarias*

Doeglas, H.M.G.

doi:10.1111/j.1365-2133.1975.tb06732.x

Cited by 149 publications

(33 citation statements)

References 18 publications

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“…Although aspirin induces urticaria and/or angioedema in 0.07–0.2% of the general population, approximately one third of the patients with chronic idiopathic urticaria under remission experience an urticarial attack after using aspirin or NSAIDs and 70% of the patients with active disease have aggravation [4,19,20,21]. In our CU patients, the prevalence of NSAIDH was close to that stated in the literature, with 22–26% of patients with chronic idiopathic urticaria having an exacerbation after aspirin challenge [22, 23]. In our study, 12% of all CU patients and 48.3% of CU patients with a history of NSAIDH presented with documented aspirin hypersensitivity.…”

Section: Discussionsupporting

confidence: 62%

Association between Asthma, Rhinitis and NSAID Hypersensitivity in Chronic Urticaria Patients and Prevalence Rates

Karakaya¹,

Çelikel²,

Demir³

et al. 2009

Int Arch Allergy Immunol

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Background: The coexistence of allergic diseases and chronic urticaria (CU) is not uncommon. Our aim was to show the prevalence of allergic diseases in chronic urticaria patients and whether possible risk factors precipitate the development of these conditions. Methods: The data of 953 patients diagnosed with CU in our adult allergy clinic between January 1991 and June 2006 were retrospectively evaluated. Results: The mean ages of the CU patients with and without non-steroidal anti-inflammatory drug hypersensitivity (NSAIDH) were 39.0 ± 11.8 and 36.7± 12.3, respectively (p = 0.014). There was a female predominance in both groups (74.6 and 68.2%, respectively, p = 0.06). Apparently, some conditions occurred significantly more often in CU patients with NSAIDH compared to those without NSAIDH: 16.4 and 8.4% for asthma (p < 0.001), 4.2 and 0.8% for nasal polyps (p < 0.01), 20.8 and 7.3% for antibiotic hypersensitivity (p < 0.001), 21.6 and 12.3% for metal sensitization (p < 0.01), and 8 and 0.6% for familial NSAIDH (p < 0.001), respectively. Dermographism was more common in CU patients without NSAIDH compared to those with NSAIDH (29.4 and 21.2%, respectively; p < 0.05). NSAIDH increased the risk of asthma and rhinitis development [odds ratios: 52.9 (18.1–154.6) and 5.2 (2.0–13.4)]. Conclusion: Based on our data, the incidence rates of asthma, nasal polyps, antibiotic hypersensitivity, metal sensitization and familial NSAIDH are increased in patients with CU with NSAIDH compared to those with CU only. Coexistence of NSAIDH and CU increases the risk of developing asthma and rhinitis.

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Section: Discussionsupporting

confidence: 62%

Association between Asthma, Rhinitis and NSAID Hypersensitivity in Chronic Urticaria Patients and Prevalence Rates

Karakaya¹,

Çelikel²,

Demir³

et al. 2009

Int Arch Allergy Immunol

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“…Nonallergic ( pseudoallergic) reactions to food preservatives and dyes have frequently cited as causes of chronic urticaria and angioedema. 64,65 These studies were mainly inadequately controlled and reproducibility was not established. In a series of 1200 patients from 1995 to 2003, Kaplan found the incidence of food allergy as a cause for chronic urticaria and angioedema to be zero (unpublished data), and the experience of one of us (M. W. G.) is similar.…”

Section: Clinical Features and Diagnosismentioning

confidence: 99%

Angioedema

Kaplan

Greaves

2005

Journal of the American Academy of Dermatology

308

235

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“…GÜLER, BAŞIMOĞLU KOCA Gıda boyaları ve koruyucuları ile yapılan araştırmalar genellikle klinik, biyokimyasal ve fizyolojik çalışmalardır. Mast hücrelerindeki yapısal değişikliklerden ziyade organizmanın genel reaksiyonunu ele alan bu çalışmalara göre; gıdalarda ve ilaçlarda yaygın olarak kullanılan katkı maddeleri, insanlarda allerjik reaksiyonlara neden olmakta ya da bu rahatsızlıkları arttırmaktadır [22,23] . Gıda katkı maddelerinin bağışıklık mekanizmasına etki edip etmediğini belirleyebilmek için, alerjik reaksiyonlarda önemli işlevi olan mast hücreleri üzerine yapılan çalışmalar bulunmaktadır [24][25][26] .…”

Section: Tartişma Ve Sonuçunclassified

Sunset Yellow FCF’ nin Tavuk Embriyosu Deri ve Barsak Mast Hücrelerinin Degranülasyonu Üzerindeki Etkileri

Güler¹,

Koca²

2013

Kafkas Univ Vet Fak Derg

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Bu çalışmada, hazır gıdalarda yapay renklendirici olarak kullanılan sunset yellow'un (E110) tavuk embriyosu dermal ve mukozal mast hücrelerindeki degranülasyon etkisi histolojik yönden incelenmiştir. Sunset yellow (2.5 mg/kg) inkübasyonun 15. gününde vitellusa enjekte edilmiştir. Enjeksiyonundan 6, 12 ve 24 saat sonra dermal ve mukozal mast hücrelerindeki degranülasyon etkisi incelenmiştir. Dermal mast hücrelerinde (deri) en fazla kısmi degranülasyon sunset yellow enjeksiyondan 12 saat, mukozal mast hücrelerinde (barsak) 6 saat sonra, en fazla ileri düzeyde degranülasyon ise deride enjeksiyondan 24 saat, barsakta 12 saat sonra gözlenmiştir. Barsaktaki mukozal mast hücrelerinde ileri degranülasyonun enjeksiyondan 24 saat sonra da devam ettiği belirlenmiştir. Her iki dokuda kısmi degranüle mast hücresi granüllerinin gevşek ve kaba granüller oluşturduğu, ileri degranülasyon gösteren mast hücrelerinin ise daha az granül içerdiklerinden dolayı daha aydınlık sitoplazmaya sahip oldukları görülmüştür. Anahtar sözcükler: Sunset yellow, Tavuk embriyosu, Mast hücresi, Deri, Barsak Degranulation Effects of Sunset Yellow-FCF on Dermal and Intestinal Mast Cells of Chicken Embryo SummaryIn this study, the degranulation effect of sunset yellow (E110) which is used as artificial coloring agent in ready food was histologically examined on dermal and mucosal mast cells of chicken embryo. Sunset yellow (2.5 mg/kg) was injected into vitellus of eggs on the 15 th day of incubation. Degranulation of dermal and mucosal mast cells were evaluated 6, 12, 24 h after injection. The most of partial degranulated in dermal mast cells (skin) was observed after 12 h from injection of sunset yellow, and after 6 h in mucosal mast cells (intestine). High level degranulation in skin was showed after 24 h from injection, and after 12 h in intestine. Also, it was seen that high level degranulation in the mucosal mast cells of intestine were continued after 24 h from injection. In both types of tissues, it was found that partially degranulated mast cells formed loose and coarse granules while mast cells showing high level of degranulation have brighter cytoplasm since they contain less granuless.

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Reactions to aspirin and food additives in patients with chronic urticaria, including the physical urticarias*

Cited by 149 publications

References 18 publications

Association between Asthma, Rhinitis and NSAID Hypersensitivity in Chronic Urticaria Patients and Prevalence Rates

Association between Asthma, Rhinitis and NSAID Hypersensitivity in Chronic Urticaria Patients and Prevalence Rates

Angioedema

Sunset Yellow FCF’ nin Tavuk Embriyosu Deri ve Barsak Mast Hücrelerinin Degranülasyonu Üzerindeki Etkileri

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