1991
DOI: 10.1007/bf00201470
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Reactivation of Epstein-Barr virus in Sjögren's syndrome

Abstract: Sjögren's syndrome (SS) is a chronic autoimmune disease characterized by severe dryness of the eyes and mouth, resulting from lymphocytic infiltration of the lacrimal and salivary glands. SS may exist as a primary condition (primary SS, 1.SS) or as a secondary condition (2.SS) in association with rheumatoid arthritis, systemic lupus erythematosus, or progressive systemic sclerosis. In some 1.SS patients, there may be involvement of the extraglandular organs, including skin, kidney, liver, lung and nervous syst… Show more

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Cited by 69 publications
(52 citation statements)
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“…The level of early Ag Abs reflects the degree of EBV viral replication, a relationship that was also observed in SS patients. Moreover, a high early Ag Ab titer was frequently detected in SS patients who developed nonHodgkin's lymphoma (45,46). The present study demonstrates that environmental contaminants such as dioxins may induce EBV reactivation and thus act as risk factors for SS.…”
Section: Discussionmentioning
confidence: 55%
“…The level of early Ag Abs reflects the degree of EBV viral replication, a relationship that was also observed in SS patients. Moreover, a high early Ag Ab titer was frequently detected in SS patients who developed nonHodgkin's lymphoma (45,46). The present study demonstrates that environmental contaminants such as dioxins may induce EBV reactivation and thus act as risk factors for SS.…”
Section: Discussionmentioning
confidence: 55%
“…What seems certain is that EBV, which usually exists in a latent form in the salivary glands, is found in a reactivated form in salivary glands in Sjogren's syndrome (Wolfetal., 1984;Saito etal, 1989;Fox et al, 1991). Also, detection of EBV in salivary epithelial cells is more frequent in areas of lympho-epithelial lesions (Karameris et al, 1992).…”
Section: Viruses and Sjogrens Syndromementioning
confidence: 99%
“…Interestingly, EBV has been linked to the etiology of similar types of disorders-autoimmune diseases, e.g., systemic lupus erythematosus (10 -14), multiple sclerosis (15)(16)(17)(18), and Sjogren's syndrome (19); malignancies, e.g., Burkitt's and Hodgkin's lymphoma (20,21), as well as, nasopharyngeal (22,23) and gastric carcinoma (24 -26); and lymphoproliferative diseases, e.g., infectious mononucleosis (27), X-linked lymphoproliferative disease (28), and posttransplant lymphoproliferative disorder (29). Due to the similarity of the types of diseases in which both superantigens and EBV have been implicated, we suspect that the HERV-K18 Env superantigen may contribute to the development of some of the EBV-associated diseases.…”
mentioning
confidence: 99%