Reactive angioendotheliomatosis and sarcoidosis

Shyong, Eileen Q.; Gorevic, Peter D.; Lebwohl, Mark; Phelps, Robert

doi:10.1046/j.1365-4362.2002.01492_1.x

Cited by 18 publications

(12 citation statements)

References 27 publications

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“…In contrast to finding noted herein, in sarcoidosis, another disease involving macrophage activation, there are predominantly regressive changes of ECs (Planes et al 1994; Tsukada et al 1995) combined with inflammation and necrosis (Takemura et al 1997). A picture of reactive angioendotheliomatosis with prominent endothelial capillary proliferation rarely seen in sarcoidosis (Shyong et al 2002) was absent in our patients.…”

Section: Discussioncontrasting

confidence: 38%

Abnormal nonstoring capillary endothelium: a novel feature of Gaucher disease. Ultrastructural study of dermal capillaries

Hůlková¹,

Poupětová²,

Harzer³

et al. 2010

J of Inher Metab Disea

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Ultrastructural study of skin biopsies in two cases of Gaucher disease (GD) patients (types II and III) revealed hitherto unknown alteration of the blood capillary endothelial cells (ECs) featured by hypertrophy and numerous subplasmalemmal microvesicles underneath both the apical and basal membranes. There was also prominent apical membrane folding with formation of filiform and large cytoplasmic projections, with occasional transcapillary cytoplasmic bridges. Similar, though less frequently expressed, changes were manifested at the basal membrane by numerous cytoplasmic projections into the subendothelial space. Regressive changes with EC breakdown were rare. Lysosomal storage was always absent. Besides EC hypertrophy, there was also increased EC density in the capillary lumen, leading to pronounced changes in capillary architecture with loose or incomplete EC anchoring. There were also signs of EC sprouting. Some pericytes displayed an increase in size and number of cytoplasmic processes, which often extended into distant pericapillary regions. The spectrum of changes suggests that a significant positive growth effect on EC occurs in GD. The putative mechanisms triggered by GBA1 deficiency leading to EC involvement are discussed. The authors are well aware of the fact the results, based on a nontraditional type of bioptic samples, are preliminary, but they are worth following, as further ultrastructural and functional studies of blood endothelium in GD may open a novel field in molecular cell pathophysiology of the disorder: endothelial dysfunction.

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Section: Discussioncontrasting

confidence: 38%

Abnormal nonstoring capillary endothelium: a novel feature of Gaucher disease. Ultrastructural study of dermal capillaries

Hůlková¹,

Poupětová²,

Harzer³

et al. 2010

J of Inher Metab Disea

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“…These processes cause occlusion of the affected vessels by intravascular deposition of cryoproteins. 160–162 …”

Section: Secondary Acrocyanosismentioning

confidence: 99%

Acrocyanosis: The Flying Dutchman

2011

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Acrocyanosis is symmetric, painless, discoloration of different shades of blue in the distal parts of the body that is marked by symmetry, relative persistence of the skin color changes with aggravation by cold exposure, and frequent association with local hyperhidrosis of hands and feet. Described over a century ago and despite seeming familiarity, it remains a poorly understood condition that shares much in clinical presentation with other conditions characterized by skin color changes in the distal parts of the body. The diagnosis remains mostly clinical, and pathological mechanisms vary suggesting that acrocyanosis may not be a single entity. We performed an extensive literature review to summarize existing knowledge about the demographics, pathology, diagnosis, and treatment of this condition.

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“…A summary of the clinical and histopathologic features of these entities is presented in Table 1. 3,4,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][28][29][30][31][32][33][34][35][36][37][38] Our case supports the previous proposal that both RAE and IH are actually 2 different aspects of the same Majority: B cells phenotype; CD20 + , CD79a + , MUM1 + (95%), bcl-2 + (91%), CD3 2 ; Rare: T/NK-cell phenotype 35 Immunofluorescence findings Granular deposits of IgA, IgM, and complement may be found around the vessels and at the DEJ 34 …”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][9][10][11][12][13][14][15][16][17][18][19][20][21][22] Most of them were associated with infections such as acute otitis media and pulmonary tuberculosis, coexistent systemic diseases (renal disease, valvular cardiac disease, alcoholic cirrhosis, and rheumatoid arthritis/polymyalgia rheumatica), blood disorders (myelodysplastic syndrome, cryoproteinemias, monoclonal gammopathies, antiphospholipid syndrome), and vascular abnormalities (iatrogenic arteriovenous fistulas, severe peripheral vascular atherosclerotic disease). 9,[11][12][13][14][15][16][17][18][19][20][21][22] The number of reports of IH in the literature is similar to those of RAE. 7,8 There is a frequent association of IH with rheumatoid arthritis.…”

Section: Introductionmentioning

confidence: 99%

Incidental Simultaneous Finding of Intravascular Histiocytosis and Reactive Angioendotheliomatosis

Aung

Ballester

Goldberg

et al. 2015

The American Journal of Dermatopathology

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Reactive angioendotheliomatosis (RAE) is a rare cutaneous vascular disorder characterized by intravascular hyperplasia of endothelial cells, sometimes with a vascular proliferation. Intravascular histiocytosis (IH) is a similar vascular disorder characterized by the presence of dilated vessels containing aggregates of mononuclear histiocytes (macrophages) within their lumina. Although their pathogenesis remains uncertain, there has been speculation about the possible relationship between IH and RAE. We report a case of coexistence of RAE and IH in a patient who underwent a wide reexcision of a metastatic malignant melanoma. The excision specimen did not show any residual melanoma but exhibited an intravascular collection of CD-68-positive histiocytes admixed with CD-31-positive endothelial cells and fibrin surrounded by D2-40-positive vascular wall. The presence of intravascular cells initially raised concern of intravascular invasion by melanoma. As there was no clinical lesion and immunohistochemical stains for melanocytic makers were negative, we interpret this as an incidental finding. Knowledge of this benign vascular disorder is important because the histologic changes may be mistaken for intravascular invasion of a malignant neoplasm.

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Reactive angioendotheliomatosis and sarcoidosis

Cited by 18 publications

References 27 publications

Abnormal nonstoring capillary endothelium: a novel feature of Gaucher disease. Ultrastructural study of dermal capillaries

Abnormal nonstoring capillary endothelium: a novel feature of Gaucher disease. Ultrastructural study of dermal capillaries

Acrocyanosis: The Flying Dutchman

Incidental Simultaneous Finding of Intravascular Histiocytosis and Reactive Angioendotheliomatosis

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