philic and do not readily cross cell membranes; 2 thus, they are not appreciably stored within tissues. Rather, the particles' small size enables them to be easily filtered by the kidneys without tubular resorption. 2 Given normal renal function, indigo carmine is cleared from the circulation and seen in the bladder within 5-7 minutes. 2 The side effects of indigo carmine dye are largely cardiovascular and most commonly involve hypertension and a reflex bradycardia with decreased stroke volume, leading to decreased cardiac output. Rarely, dysrhythmias, cardiac arrest, and anaphylaxis have also been reported. 1 Uncommonly, indigo carmine dye can extravasate from the peripheral line into the skin and cause a dramatic but asymptomatic blue discoloration. The three prior instances of indigo carmine extravasation were also noticed upon the completion of surgery. 1-3 As in the present case, the previously reported patients did not experience any symptoms and, other than the discoloration and edema of the affected arm, showed unremarkable findings on examination. In all cases, the discoloration resolved within 24-48 hours without any cutaneous or cardiovascular sequelae.Although indigo carmine dye extravasation into the skin is a benign, transient condition, its presentation is dramatic and can induce significant anxiety in both patients and clinicians who are unfamiliar with this complication. Dermatologists consulted for such rashes can reassure patients and the healthcare team that the discoloration will resolve completely without resultant tissue