Reactive arthritis and cutaneous vasculitis after SARS-CoV-2 infection

Schenker, Hannah; Hagen, Melanie; Simón, David; Schett, Georg; Manger, Bernhard

doi:10.1093/rheumatology/keaa689

Cited by 47 publications

(51 citation statements)

References 3 publications

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“…Investigations for HIV, syphilis, chlamydia, and gonorrhoea were negative as well as arthrocentesis [ 24 ]. A 65-year-old woman with HLA B27 positivity developed symmetrical arthritis of ankles, knees and wrists and a cutaneous vasculitis 10 days after cessation of all COVID-19-related symptoms [ 25 ]. Another patient developed inflammatory arthralgia with cyclic citrullinated peptide (CCP) antibodies which resolved with a short course of oral corticosteroids [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

Rheumatological complications of Covid 19

Zacharias

Dubey

Koduri

et al. 2021

Autoimmunity Reviews

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Introduction COVID-19 has caused unprecedented hardships in the 21st century with more than 150 million infections. Various immunological phenomena have been described during the course of the infection, and this infection has also triggered autoimmunity. Rheumatological illnesses have been described following resolution of the acute infection; hence we sought to conduct a review of the rheumatological complications of COVID-19. Methods We conducted a literature search for articles relating to sequelae of COVID-19 from Jan 2020 to 30th April 2021. Results We found a number of reports of inflammatory arthritis after SARS-CoV-2 infection. SLE and renal disease have been described, and vasculitis also appears to be a common complication. Rhabdomyolysis and myositis has also been reported in a number of patients. We also found some evidence of large vessel vasculitis in ‘long COVID’ patients. Conclusions This review highlights a number of important complications such as inflammatory arthritis, lupus-like disease, myostis and vasculitis following SARS-CoV-2 infection.

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Section: Resultsmentioning

confidence: 99%

Rheumatological complications of Covid 19

Zacharias

Dubey

Koduri

et al. 2021

Autoimmunity Reviews

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“…Although ReA causes asymmetric oligoarthritis in the lower extremities, a mild form of upper limb arthritis can also occur, as seen in our patient [ 6 ]. In contrast to this, Danssaert et al [ 5 ] reported arthritis of unilateral hand joints without involvement of lower extremities.…”

mentioning

confidence: 57%

“…Liew et al [ 4 ] described a patient with acute right knee arthritis manifesting 3 days after fever and simultaneously being positive for SARS-CoV-2 infection. Schenker et al [ 6 ] and De Stefano et al [ 7 ] described cases of ReA associated with cutaneous vasculitis and psoriatic skin lesions, respectively. The patient reported by Ono et al [ 2 ] had severe respiratory distress requiring mechanical ventilation, whereas respiratory involvement was milder in the other five patients [ 3–7 ], including our patient.…”

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confidence: 99%

Reactive arthritis after SARS-CoV-2 infection

Sureja¹,

Nandamuri

2021

Rheumatology Advances in Practice

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“…Enthesitis of the Achilles tendon and psoriatic lesions consistent with spondyloarthritis have also been observed [62,66]. Extra-articular involvement of palpable purpura of both calves was seen in one HLA-B27 positive patient [67]. HLA-B27 is otherwise negative, although this has been investigated in only one case.…”

Section: New Infectious Agents Implicated In the Causation Of Reactive Arthritismentioning

confidence: 93%

“…With the advent of the SARS-CoV-2 pandemic, several cases of acute arthritis following this viral infection were reported and classified as ReA (Table 3) [62][63][64][65][66][67][68][69]. The first review published in October 2020 as preprint discussed whether SARS-CoV-2 can trigger ReA [70•].…”

Section: New Infectious Agents Implicated In the Causation Of Reactive Arthritismentioning

confidence: 99%

Reactive Arthritis Update: Spotlight on New and Rare Infectious Agents Implicated as Pathogens

Zeidler

Hudson

2021

Curr Rheumatol Rep

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Purpose of Review This article presents a comprehensive narrative review of reactive arthritis (ReA) with focus on articles published between 2018 and 2020. We discuss the entire spectrum of microbial agents known to be the main causative agents of ReA, those reported to be rare infective agents, and those reported to be new candidates causing the disease. The discussion is set within the context of changing disease terminology, definition, and classification over time. Further, we include reports that present at least a hint of effective antimicrobial therapy for ReA as documented in case reports or in double-blind controlled studies. Additional information is included on microbial products detected in the joint, as well as on the positivity of HLA-B27. Recent Findings Recent reports of ReA cover several rare causative microorganism such as Neisseria meningitides, Clostridium difficile, Escherichia coli, Hafnia alvei, Blastocytosis, Giardia lamblia, Cryptosporidium, Cyclospora cayetanensis, Entamoeba histolytica/dispar, Strongyloides stercoralis, β-haemolytic Streptococci, Mycobacterium tuberculosis, Mycoplasma pneumoniae, Mycobacterium bovis bacillus Calmette-Guerin, and Rickettsia rickettsii. The most prominent new infectious agents implicated as causative in ReA are Staphylococcus lugdunensis, placenta-and umbilical cord-derived Wharton's jelly, Rothia mucilaginosa, and most importantly the SARS-CoV-2 virus. Summary In view of the increasingly large spectrum of causative agents, diagnostic consideration for the disease must include the entire panel of post-infectious arthritides termed ReA. Diagnostic procedures cannot be restricted to the well-known HLA-B27-associated group of ReA, but must also cover the large number of rare forms of arthritis following infections and vaccinations, as well as those elicited by the newly identified members of the ReA group summarized herein. Inclusion of these newly identified etiologic agents must necessitate increased research into the pathogenic mechanisms variously involved, which will engender important insights for treatment and management of ReA.

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Reactive arthritis and cutaneous vasculitis after SARS-CoV-2 infection

Cited by 47 publications

References 3 publications

Rheumatological complications of Covid 19

Rheumatological complications of Covid 19

Reactive arthritis after SARS-CoV-2 infection

Reactive Arthritis Update: Spotlight on New and Rare Infectious Agents Implicated as Pathogens

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