Reactive Arthritis Induced by Tonsillitis: A Type of ‘Focal Infection’

Kobayashi, Shigeto; Ichikawa, Ginichiro

doi:10.1159/000324612

Cited by 7 publications

(4 citation statements)

References 5 publications

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“…Our findings correspond with those of authors Kobayashi S. Ishikava G. et al ( 21 ), and Izairi R. Rexhepi S. et al ( 22 ). In numerous papers E. coli, Beta hemolytic Streptococcus, Staphylococcus, Giardia lamblia, Borellia burgdorferi, N. gonorrheae, interpheron, vaccine against hepatitis B, vaccine BCG in the cancer of urine bladder are considered as a possible causative agents of reactive arthritis.…”

Section: Discussionsupporting

confidence: 93%

The Source of Infection and the Most Frequent Causes of Reactive Arthritis in Kosovo

Lahu

Bajraktari

Lahu³

et al. 2016

Mater Sociomed

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Introduction:Reactive arthritis is an autoimmune condition which emerges as a counteraction towards an infection which has a focus elsewhere in the body. The purpose of this study is isolation of causative agents of reactive arthritis and ascertains the source of infection. The study has been carried out in the Rheumatology Clinic in Prishtina and specialized ambulance O.S. “Vendenisi-AL” in Besiana, whereas isolation of causative agents has been carried out in the National Institute for Public Health (NIPH). The study has prospective, comparative and analytical feature.Results:Out of 100 patients, 66% were males and 34% females. Among males we have noticed domination of post-urethritis and post-streptococcic reactive arthritis, whereas among females dominates reactive arthritis of enteral etiology. The study concludes that: urogenital tract was the source of infection with 66% of cases, nasopharyngeal tract with 19% of cases, and enteral tract with 15% of cases respectively. Predominantly presents bacteria are E. Coli with 21%, Staphylococcus aureus with 20%, Streptococcus B. hem. gr. A with 16% of cases respectively and other species.Conclusion:frequency of arthritis with urogenital etiology was 2:1 in favor of males, with nasopharyngeal etiology 3:1 in favor of males, whereas in arthritis with enteral etiology we have noticed a slight dominance in favor of females.

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Section: Discussionsupporting

confidence: 93%

The Source of Infection and the Most Frequent Causes of Reactive Arthritis in Kosovo

Lahu

Bajraktari

Lahu³

et al. 2016

Mater Sociomed

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“…Tonsillitis is a leading disease in otolaryngology, and the admission for tonsillitis was found to rise by 310% between 2003 and 2011 in the United Kingdom [6, 7]. Notably, tonsillitis has recently been implicated in the development of autoimmune arthritis including reactive arthritis and rheumatoid arthritis (RA), and gut dysbiosis appears to play an essential role in the linkage between infectious diseases and autoimmune arthritis [8–10]. However, the data regarding AS and tonsillitis, particularly in the adulthood tonsillitis, remains limited [11].…”

Section: Introductionmentioning

confidence: 99%

Association between tonsillitis and newly diagnosed ankylosing spondylitis: A nationwide, population-based, case-control study

et al. 2019

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Objectives To investigate the association between tonsillitis and the risk of newly diagnosed ankylosing spondylitis (AS). Methods We used 2003–2012 data from Taiwan’s National Health Insurance Research Database to conduct this nationwide, population-based, case-control study. We identified AS patients newly diagnosed between 2005 to 2012 as the study group and selected age, sex and index-year matched (1:6) non-AS individuals as controls. The association between tonsillitis and risk of newly diagnosed AS was determined by calculating odds ratios (ORs) with 95% confidence intervals (CIs) using conditional logistic regression analysis. Results We identified 37,002 newly diagnosed AS cases and 222,012 matched non-AS controls. Patients with AS were more likely to have tonsillitis (aOR 1.46, 95% CI 1.43–1.50), appendicitis (aOR 1.29, 95% CI 1.13–1.48) and periodontitis (aOR 1.35, 95% CI 1.31–1.38) than non-AS control subjects. The association between tonsillitis and AS was consistent using varying definitions for tonsillitis, and we further found that a high frequency of visits for tonsillitis, a high medical cost for tonsillitis and a long interval between diagnosis were associated with newly diagnosed AS in a dose-response manner. Furthermore, the association between tonsillitis and AS appeared to be stronger in females (aOR 1.59, 95% CI 1.53–1.65) than those in males (aOR 1.39, 95% CI 1.35–1.44). Conclusions The present study revealed an association between AS risk and prior tonsillitis and indicates the need for vigilance of AS-associated symptoms in patients who had been diagnosed with tonsillitis, particularly in females.

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“…In immunoglobin A nephropathy (IgAN), tonsillectomy combined with steroid pulse therapy was revealed to induce significant remission of the disease 15,17,18 . Additionally, several other diseases, such as psoriatic diseases, 19‐21 reactive arthritis 22 and IgA vasculitis, 23 were reported to be tonsil‐related. Additionally, PPP is known to cause typical tonsillar focal diseases, as shown in multiple studies 3,24,25 .…”

Section: Discussionmentioning

confidence: 99%

Tonsillitis as a possible predisposition to synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome

et al. 2021

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Aim To present the prevalence of tonsillitis in synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) patients, to compare the clinical characteristics and disease activities between SAPHO patients with and without tonsillitis and to preliminarily explore the efficacy of tonsillectomy in SAPHO syndrome. Method A total of 58 SAPHO patients were included. Clinical data were collected, including demographic characteristics and acute phase reactants (erythrocyte sedimentation rate, high‐sensitivity C‐reactive protein). The visual analog scale (VAS), Palmoplantar Pustule Psoriasis Area Severity Index (PPPASI) and Nail Psoriasis Severity Index (NAPSI) were used to measure the severity of bone pain, skin lesions and nail lesions, respectively. Patients were referred to the otolaryngology department for tonsil examinations, including tonsil hypertrophy (grade ≥ 2), chronic congestion, inflammatory secretion and tonsil stones. The patients who underwent tonsillectomy were followed up after the surgery. Results A total of 67.2% of patients had tonsillitis. Patients with tonsillitis had markedly higher PPPASI (1.2 [0, 7.4] vs. 7.6 [1.75, 15.5], P = .018) and NAPSI (0 [0, 21] vs. 8 [3, 28], P = .032) scores. After tonsillectomy, the patients experienced significantly improved bone pain (VAS, 5 [4, 7] vs. 3 [1, 4], P = .034) and skin lesions (PPPASI, 16.2 [7.05, 18.35] vs 1.8 [0.7, 3.7], P = .028). Conclusion Approximately 2/3 of SAPHO patients had tonsillitis. Patients with tonsillitis had more severe skin and nail lesions. Tonsillectomy might be associated with improved bone and skin symptoms in SAPHO patients. Future prospective controlled studies are warranted.

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Reactive Arthritis Induced by Tonsillitis: A Type of ‘Focal Infection’

Abstract: Sterile inflammatory arthritis induced by tonsillitis was cured by resection of the microabscess in the tonsils. Therefore, ReA induced by tonsillitis is one form of 'focal infection'.

Cited by 7 publications

References 5 publications

The Source of Infection and the Most Frequent Causes of Reactive Arthritis in Kosovo

The Source of Infection and the Most Frequent Causes of Reactive Arthritis in Kosovo

Association between tonsillitis and newly diagnosed ankylosing spondylitis: A nationwide, population-based, case-control study

Tonsillitis as a possible predisposition to synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome

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