Reactive crystallization of calcium carbonate in a batch crystallizer

Kotaki, Yasushi; Tsuge, Hideki

doi:10.1016/s0022-0248(08)80087-5

Cited by 12 publications

(5 citation statements)

References 3 publications

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“…The easiest way to test the effect of an additive on the calcium carbonate crystallization is to use a reactive crystallization by the liquid–liquid reaction method also referred to as the solution method. It based on the process in which supersaturation is achieved by a chemical reaction between two soluble reactantsin the calcium carbonate case by mixing a soluble salt of calcium (e.g., calcium chloride) with a soluble salt of carbonate (e.g., sodium carbonate). − The process may be performed inside a reactor, with three cells that are separated by a porous membrane where calcium and carbonate diffuse from the outer to the middle cell resulting in the precipitation of the less soluble calcium carbonate, or simply by the direct adding and fast mixing of these two solutions. ,, The second approach was used to study, for example, the incorporation of recombinant Perlucin protein, , the effect of recombinant sea urchin spicule matrix protein, rSpSM50, on the calcium carbonate mineralization process, as well as to screen the incorporation of amino acids into the crystalline lattice of calcite . The method is fast and very simple.…”

Section: Background Of the In Vitro Biomineralization Systems And Cou...mentioning

confidence: 99%

Counter-Diffusion System as an in Vitro Model in the Investigation of Proteins Involved in the Formation of Calcium Carbonate Biominerals

Bielak

Różycka

Zoglowek

et al. 2021

Crystal Growth & Design

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Mineralization in living organisms is highly regulated by the synergistic action of many macromolecules, where distinctive proteins play the role of direct modulators of the crystal growth. The number of methods for in vitro biomineralization studies in the presence of proteins is limited due to the influence of the environment on their functionality. We focus on a counter-diffusion system in the biomineralization of calcium carbonate that is based on the diffusion of salt solutions through a gel-matrix supplemented with the protein of interest. This article discusses the background of the system, physical principles, matrices commonly in use, advantages, limitations, variations, and our own experience. Special attention is paid to the overview of already published studies that applied the counter-diffusion system as a model for investigation of the biomineralization of calcium carbonate. The system has great potential to be widely used in the analysis of biomineralization-associated proteins in vitro and the biomineralization process itself. This perspective recalls the most important theoretical basis as well as practical application of the system for specialists in various fields of biomineralization.

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Section: Background Of the In Vitro Biomineralization Systems And Cou...mentioning

confidence: 99%

Counter-Diffusion System as an in Vitro Model in the Investigation of Proteins Involved in the Formation of Calcium Carbonate Biominerals

Bielak

Różycka

Zoglowek

et al. 2021

Crystal Growth & Design

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“…where the volume shape factor k v is taken as 1.0 according to Kotaki and Tsuge. [52] Parameters used in the simulation are summarized in Table 1.…”

Section: Chemical Reactions and Mass Transfermentioning

confidence: 99%

“…

Γ_{eff} = μ_{normalt} / S c_{t}

, with Sc t equal to 0.7 . The source term S g is the specific crystal growth rate calculated by:

S_{normalg} = 3 ρ_{1} m_{2} G k_{v} \frac{ρ_{normals}}{M_{normals}}

where the volume shape factor k v is taken as 1.0 according to Kotaki and Tsuge . Parameters used in the simulation are summarized in Table .…”

Section: Mathematical Modelsmentioning

confidence: 99%

CFD‐PBE‐PBE simulation of an airlift loop crystallizer

Cheng

Yang

et al. 2018

Can J Chem Eng

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A complete solver (CFD‐PBE‐PBE) for crystallization processes in an airlift loop crystallizer is developed in OpenFOAM (open‐source field operation and manipulation) in this work. It combines computational fluid dynamics (CFD) with population balance equations (PBE) for both gas bubbles and crystals. Models for gas‐liquid mass transfer and chemical reaction are included as well in the solver. PBE describing bubble coalescence and breakage is solved by the cell average method. Primary nucleation, secondary nucleation, and particle growth are considered in the PBE describing the crystallization process. The solver is validated with the formation of calcium carbonate via the reaction of CO2 with Ca(OH)2 solution in an airlift reactor. Effects of the chemical enhancement factor and crystallization kinetics on predictions are systematically investigated. Variation of predicted pH value, concentration of Ca2+, mean particle size, and crystal size distribution (CSD) with time is in qualitative and semi‐quantitative agreement with the published experimental data, when the appropriate crystallization kinetics are used. Effects of operation parameters such as initial concentration and superficial gas velocity are further numerically examined. The increase in superficial gas velocity results in the increasing consumption rates of OH‐ and Ca2+, while the particle diameter seems unchanged in the present simulation. A higher initial concentration of reactants will lead to a smaller particle diameter and a narrower CSD. The predicted results indicate that the developed solver is feasible, and can be used for the design and scale‐up of airlift loop crystallizers.

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“…The limited literature on continuous reactive crystallization is mainly for inorganic materials or for standard CSTR or tubular designs , . Tavare et al studied a process involving the elementary chemical reaction between two reactants, subsequent crystallization of the product took place in a continuous crystallizer.…”

Section: Introductionmentioning

confidence: 99%

Continuous reactive crystallization of pharmaceuticals using impinging jet mixers

et al. 2016

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For reactive crystallization of pharmaceuticals that show rapid reaction rate, low solubility of active pharmaceutical ingredient, hence large supersaturation, it was found in a recent study that a process design that integrates an impinging jet mixer and a batch stirred tank, the former to achieve intensive micromixing prior to reaction and crystal nucleation and the later to immediately disperse the formed nuclei or small particles to minimise aggregation but promote crystal growth, has produced high quality crystals. The current investigation studies the hypothesis that due to the short processing time of reactive crystallization, the impinging jet mixer -stirred tank design can be made to operate in continuous mode. The new design combines an impinging jet mixer for feed introduction and reaction, and a continuous stirred tank reactor (CSTR) and a tubular reactor for crystal growth. Study on reactive crystallization of sodium cefuroxime (an antibiotic), using firstly in a 1L CSTR then scaled to 50L CSTR, found that the new design has produced crystals of higher crystallinity, narrower particle size, and improved product stability, than the conventional batch crystallizer.

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Reactive crystallization of calcium carbonate in a batch crystallizer

Cited by 12 publications

References 3 publications

Counter-Diffusion System as an in Vitro Model in the Investigation of Proteins Involved in the Formation of Calcium Carbonate Biominerals

Counter-Diffusion System as an in Vitro Model in the Investigation of Proteins Involved in the Formation of Calcium Carbonate Biominerals

CFD‐PBE‐PBE simulation of an airlift loop crystallizer

Continuous reactive crystallization of pharmaceuticals using impinging jet mixers

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