Reactive crystallization of methyl .ALPHA.-methoxyimino acetoacetate.

Momonaga, Masashi; Yazawa, Hisatoyo; Kagara, Koji

doi:10.1252/jcej.25.237

Cited by 6 publications

(4 citation statements)

References 6 publications

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“…Publications concerning the scale-up of precipitation are very sparse in the literature. Momonaga et al 8 introduced a mixing-dependent scale-up factor based on equal power input per unit volume. They scaled up the batch precipitation process of methyl R-methoxyimino acetoacetate but did not carry out a study of the precipitation kinetics.…”

Section: Literaturementioning

confidence: 99%

“…This technique ensures high accuracy and a constant residence time. A Spectrum PCLab unit (8) controls the temperature in the reactor and measures process variables on-line. The reactor jacket is thermostated by either cooling or heating water, according to the desired reactor temperature, using a Haake thermostatic bath (7).…”

Section: Experimental Setup and Proceduresmentioning

confidence: 99%

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Scale-up of Continuous and Semibatch Precipitation Processes

Zauner

Jones

2000

Ind. Eng. Chem. Res.

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A segregated feed model linked to the population balance, which includes micromixing and mesomixing effects together with crystallization and agglomeration kinetics, is proposed for scaling up reactive precipitation processes. The model is solved using kinetic parameters extracted from laboratory-scale experiments together with local mixing parameters obtained from a computational fluid dynamics simulation. Predicted particle size characteristics are compared with experimental data collected on three different scales of operation (range 0.3-25 L) using the aqueous calcium oxalate system. The hybrid precipitation-mixing model accurately predicts mixing effects observed during the continuous mode of operation, including a maximum in the mean particle size and coefficient of variation with increasing power input on each of the three different scales. The influence of mixing on the mean particle size in semibatch operation is found to be more pronounced owing to the direct mixing of the feed solution with the other component already present in the reactor, and is also correctly predicted by the hybrid model.

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Section: Literaturementioning

confidence: 99%

Section: Experimental Setup and Proceduresmentioning

confidence: 99%

Scale-up of Continuous and Semibatch Precipitation Processes

Zauner

Jones

2000

Ind. Eng. Chem. Res.

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“…15 The influence of mixing on the physical properties of chemical and biological-based precipitates has been studied vigorously. [16][17][18] Based on the studies, scale-up on the basis of mixing using the specific power input and tip speed constants have been proposed for batch precipitations. The challenge arises when more than one mixing mechanism (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…14 The influence of mixing on the physical properties of chemical and biological-based precipitates has been studied vigorously. [15][16][17] Based on those studies, scale-up based on mixing using the specific power input and tip speed constants has been proposed for batch precipitations. The challenge arises when more than one mixing mechanism (e.g., micro-mixing, meso-mixing, and macro-mixing) is controlling the process, and, as a result, the final product is affected due to the variation of flow patterns between scales.…”

Section: Introductionmentioning

confidence: 99%

Reactor design for continuous monoclonal antibody precipitation based upon micro‐mixing

Martinez

Mannall

Spitali

et al. 2021

J of Chemical Tech & Biotech

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BACKGROUND: Precipitation has seen application for the processing of important therapeutics including monoclonal antibodies (mAbs). The scale-up proves to be a challenging task due to the complexity of the reactions and transport processes involved. This requires a good understanding of the molecular processes underpinning precipitate formation.The aim of the study was to build a micro-mixing model for the precipitation of a mAb in continuous tubular reactors using ammonium sulphate. The effect of micro-mixing on precipitate formation with respect to size, strength and nature was evaluated. An ultra scaledown (USD) centrifugation methodology was applied to determine the ease of precipitate clarification.This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as

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Synthesis of reactive crystallization processes

Berry

1997

AIChE Journal

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Reactive crystallization of methyl .ALPHA.-methoxyimino acetoacetate.

Cited by 6 publications

References 6 publications

Scale-up of Continuous and Semibatch Precipitation Processes

Scale-up of Continuous and Semibatch Precipitation Processes

Reactor design for continuous monoclonal antibody precipitation based upon micro‐mixing

Synthesis of reactive crystallization processes

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