This work demonstrates how to apply the Theory of Inventive Problem Solving (Russian acronym TRIZ) on two industrial-scale case studies. The first case study addresses processing of mineral metal carbonates, which is characterized by high CO 2 emissions and high energy demand. As solver strategy a novel reductive pathway is suggested. The second case study refers to biobased industrial processes, which discharge aqueous effluents with unexploited carboxylic acid loads. Reactive separations are proposed to isolate the carboxylic acids. In both solver strategies, chemical reactions adopt a central role.