Reactive extraction of succinic acid with tripropylamine (TPA) in various diluents

Hong, Yeon Ki; Wang, Hong

doi:10.1007/s004490050733

Cited by 33 publications

(18 citation statements)

References 9 publications

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“…A variety of different downstream processing methods for bio-succinic acid, like precipitation with calcium hydroxide or ammonium, electrodialysis, ion exchange and adsorption, crystallisation and liquid-liquid extraction have been reviewed recently [7]. Most of these separation technologies showed low selectivities and/or low yields with the exception of reactive extraction with high molecular weight amines solved in non-water-miscible organic solvents [8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 98%

New reactive extraction systems for separation of bio-succinic acid

Kurzrock

Weuster‐Botz

2011

Bioprocess Biosyst Eng

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Biotechnologically produced succinic acid has the potential to displace maleic acid and its uses and to become an important feedstock for the chemical industry. In addition to optimized production strains and fermentation processes, an efficient separation of succinic acid from the aqueous fermentation broth is indispensable to compete with the current petrochemical production processes. In this context, high molecular weight amines are known to be effective extractants for organic acids. For this reason, as a first step of isolation and purification, the reactive extraction of succinic acid was studied by mixing aqueous succinic acid solutions with 448 different amine-solvent mixtures as extraction agents (mixer-settler studies). The extraction agents consist either of one amine and one solvent (208 reactive extraction systems) or two amines and two solvents (240 reactive extraction systems). Maximum extraction yields of succinic acid from an aqueous solution with 423 mM succinic acid at pH 2.0 were obtained with more than 95% yield with trihexylamine solved in 1-octanol or with dihexylamine and diisooctylamine solved in 1-octanol and 1-hexanol. Applying these optimized reactive extraction systems with Escherichia coli fermentation broth resulted in extraction yields of 78-85% due to the increased ionic strength of the fermentation supernatant and the co-extraction of other organic acids (e.g., lactic acid and acetic acid), which represent typical fermentation byproducts.

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Section: Introductionmentioning

confidence: 98%

New reactive extraction systems for separation of bio-succinic acid

Kurzrock

Weuster‐Botz

2011

Bioprocess Biosyst Eng

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“…An equilibrium description of this system can be written as a set of reaction of succinic acid A, tertiary amine B, and diluent D molecule. Overbar indicates the organic phase [3,9]:…”

Section: Methodsmentioning

confidence: 99%

“…The concentration of succinic acid was analyzed by 0.05 N NaOH using the phenolphthalein as an indicator [9,10]. Mixed tertiary amine dissolved in a 3:7 1-octanol/n-heptane diluent was used in reactive extraction of various concentration of succinic acid.…”

Section: Methodsmentioning

confidence: 99%

Extraction of succinic acid with 1-octanol/ n-heptane solutions of mixed tertiary amine

Hong

Wang

2000

Bioprocess Engineering

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The reactive extraction of succinic acid was carried out by mixed tertiary amine which consisted of tripropylamine (TPA) and trioctylamine (TOA) as the extraction agent in 1-octanol/n-heptane diluent. Maximum distribution coef®cient was obtained at 8:2 weight ratio of TPA/TOA. At this ratio, its extraction ef®ciency is above 90% at the 3.9 wt.% of succinic acid in aqueous solution. Furthermore, the prevention of the third phase formation made the phase separation between organic phase and aqueous phase easy.

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“…Then, the complexes formed during the reactions are solubilized in the organic phase. The most used extractants for the reactive extraction of carboxylic acids are hydrocarbon, phosphorous, and aliphatic amine [39]. Thus, three categories of extractions are recognized: (1) extraction by solvation with carbon-bonded oxygen-bearing extractants, (2) salvation with phosphorous-bonded oxygen-bearing extractants, and (3) proton transfer or ion-pairing formation with high molecular weight aliphatic amines and their salts [40].…”

Section: Lactic Acid Recovery and Purificationmentioning

confidence: 99%

Analysis of the Production Process of Optically Pure d-Lactic Acid from Raw Glycerol Using Engineered Escherichia coli Strains

Posada

Cardona

González

2011

Appl Biochem Biotechnol

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Glycerol has become an ideal feedstock for producing fuels and chemicals. Here, five technological schemes for optically pure D: -lactic acid production from raw glycerol were designed, simulated, and economically assessed based on five fermentative scenarios using engineered Escherichia coli strains. Fermentative scenarios considered different qualities of glycerol (pure, 98 wt.%, and crude, 85 wt.%) with concentrations ranging from 20 to 60 g/l in the fermentation media, and two fermentation stages were also analyzed. Raw glycerol (60 wt.%) was considered as the feedstock feeding the production process in all cases; then a purification process of raw glycerol up to the required quality was required. Simulation processes were carried out using Aspen Plus, while economic assessments were performed using Aspen Icarus Process Evaluator. D: -Lactic acid recovery and purification processes were based on reactive extraction with tri-n-octylamine using dichloromethane as active extractant agent. The use of raw glycerol represents only between 2.4% and 7.8% of the total production costs. Also, the total production costs obtained of D: -lactic acid in all cases were lower than its sale price indicating that these processes are potentially profitable. Thus, the best configuration process requires the use of crude glycerol diluted at 40 g/l with total glycerol consumption and with D: -lactic acid recovering by reactive extraction. The lowest obtained total production cost was 1.015 US$/kg with a sale price/production cost ratio of 1.53.

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Reactive extraction of succinic acid with tripropylamine (TPA) in various diluents

Cited by 33 publications

References 9 publications

New reactive extraction systems for separation of bio-succinic acid

New reactive extraction systems for separation of bio-succinic acid

Extraction of succinic acid with 1-octanol/ n-heptane solutions of mixed tertiary amine

Analysis of the Production Process of Optically Pure d-Lactic Acid from Raw Glycerol Using Engineered Escherichia coli Strains

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