Reactive intravascular histiocytosis associated with tonsillitis

Asagoe, Kenji; Torigoe, Rikako; Ofuji, Reiko; Iwatsuki, Keiji

doi:10.1111/j.1365-2133.2005.07089.x

Cited by 26 publications

(24 citation statements)

References 10 publications

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“…7,[24][25][26] In IH, the majority of the intraluminal cells express CD68 and but are negative for CD31/CD34. 7,8,[24][25][26] In the previous reported cases of IH, the intravascular epithelioid cells were consistent with histiocytes histologically (oval nuclei with abundant eosinophilic cytoplasm) and confirmed to be histiocytes immunohistologically (CD68/Mac 387 + and CD31/CD34 2 ) and ultrastructurally. 7,8 The pathogenesis of RAE and IH are not fully understood.…”

Section: Discussionmentioning

confidence: 99%

“…A summary of the clinical and histopathologic features of these entities is presented in Table 1. 3,4,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][28][29][30][31][32][33][34][35][36][37][38] Our case supports the previous proposal that both RAE and IH are actually 2 different aspects of the same Majority: B cells phenotype; CD20 + , CD79a + , MUM1 + (95%), bcl-2 + (91%), CD3 2 ; Rare: T/NK-cell phenotype 35 Immunofluorescence findings Granular deposits of IgA, IgM, and complement may be found around the vessels and at the DEJ 34 …”

Section: Discussionmentioning

confidence: 99%

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Incidental Simultaneous Finding of Intravascular Histiocytosis and Reactive Angioendotheliomatosis

Aung

Ballester

Goldberg

et al. 2015

The American Journal of Dermatopathology

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Reactive angioendotheliomatosis (RAE) is a rare cutaneous vascular disorder characterized by intravascular hyperplasia of endothelial cells, sometimes with a vascular proliferation. Intravascular histiocytosis (IH) is a similar vascular disorder characterized by the presence of dilated vessels containing aggregates of mononuclear histiocytes (macrophages) within their lumina. Although their pathogenesis remains uncertain, there has been speculation about the possible relationship between IH and RAE. We report a case of coexistence of RAE and IH in a patient who underwent a wide reexcision of a metastatic malignant melanoma. The excision specimen did not show any residual melanoma but exhibited an intravascular collection of CD-68-positive histiocytes admixed with CD-31-positive endothelial cells and fibrin surrounded by D2-40-positive vascular wall. The presence of intravascular cells initially raised concern of intravascular invasion by melanoma. As there was no clinical lesion and immunohistochemical stains for melanocytic makers were negative, we interpret this as an incidental finding. Knowledge of this benign vascular disorder is important because the histologic changes may be mistaken for intravascular invasion of a malignant neoplasm.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Incidental Simultaneous Finding of Intravascular Histiocytosis and Reactive Angioendotheliomatosis

Aung

Ballester

Goldberg

et al. 2015

The American Journal of Dermatopathology

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“…Additionally, many authors adopt the name intralymphatic histiocytosis, as years go by, instead of intravascular histiocytosis. Among the 2 cases described as intravascular histiocytosis in 2009, 1 patient was a 17-year-old male with tonsillitis [14] and the other suffered from vulva necrosis but her symptoms rapidly diminished after the bacterial infection had cured [15]. These 2 cases had atypical features and should be treated as exceptional disease compared with typical intralymphatic histiocytosis associated with RA.…”

Section: Discussionmentioning

confidence: 99%

Pressure Bandage as an Effective Treatment for Intralymphatic Histiocytosis Associated with Rheumatoid Arthritis

Washio¹,

Nakata²,

Nakamura³

et al. 2011

Dermatology

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The patient is a 71-year-old male who has been suffering from rheumatoid arthritis for over 20 years. He first noticed the erythema on his right forearm in 2008, which got worse in 2009. Topical corticosteroids were not effective, and a skin biopsy was performed. Histopathologic examination showed aggregation of the inflammatory cells in the dermal vessels. Those cells were positive for CD68 and CD31 and all the surrounding vessels expressed D2–40 and CD31. We diagnosed him with intralymphatic histiocytosis. One week after the skin was biopsied, only the part of the erythematous lesion covered by skin tape had improved, suggesting that pressure on the lesion might improve the erythematous eruption. We therefore used a pressure bandage elbow supporter in addition to topical treatment. The lesion improved 3 months later and was totally diminished after 9 months. Combined with previously reported cases, our case suggested that intralymphatic histiocytosis is closely related to lymphostasis.

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“…Since then, the name ''intralymphatic histiocytosis'' has been preferred to describe additional examples of this disorder. [7][8][9][10][11] Herein, we describe our experience with 16 cases of intralymphatic histiocytosis and expand on the previously described morphologic and immunohistochemical features of this disorder. We also discuss the histopathologic differential diagnosis with intravascular lymphoma and the possible relationship between intralymphatic histiocytosis and the so-called reactive intravascular angioendotheliomatosis.…”

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confidence: 87%

Intralymphatic Histiocytosis. A Clinicopathologic Study of 16 Cases

Requena

El-Shabrawi-Caelen²,

Walsh³

et al. 2009

The American Journal of Dermatopathology

102

162

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Intralymphatic histiocytosis is a rare condition characterized by the presence of dilated lymphatic vessels containing aggregates of mononuclear histiocytes (macrophages) within their lumina. The phenomenon seems to occur almost exclusively within the reticular dermis. Although its pathogenesis remains uncertain, there has been speculation about the possible relationship between intralymphatic histiocytosis and intravascular reactive angioendotheliomatosis. In addition, several examples historically have been associated with rheumatoid arthritis. We describe our experience with 16 cases of intralymphatic histiocytosis. Clinically, the lesions were located predominantly on the upper and lower limbs, and they consisted of asymptomatic and poorly demarcated erythematous plaques and livedo reticularis-like lesions. They were characterized histopathologically by dilated vascular structures involving the reticular dermis. Some of these dilated vessels had empty lumina, whereas others contained variable number of mononuclear histiocytes. An inflammatory response of variable intensity from case to case was also present in the adjacent dermis. The dilated vessels exhibited thin walls with irregular shapes, and a single discontinuous layer of flat endothelial cells lined their lumina. Immunohistochemically, the endothelial cells lining the dilated lumina expressed immunoreactivity for CD31, CD34, podoplanin, D2-40, Lyve-1, and Prox-1, which confirmed their nature as lymphatic endothelial cells. Intralymphatic mononuclear histiocytes expressed CD68 (PGM1), although some cases also had variable immunoexpression for myeloperoxidase, CD31, and podoplanin. In the 4 cases that employed double immunohistochemistry, with podoplanin + CD68 (PGM1) or with Lyve-1 + CD68 (PGM1), each marker highlighted their specific target cells unequivocally; the endothelial cells expressed podoplanin or Lyve-1 immunoreactivity, and intralymphatic histiocytes showed CD68 (PGM1) immunoexpression. Our findings expand on the previously described morphologic and immunohistochemical features of intravascular histiocytosis. We also discuss the possible relationship between intralymphatic histiocytosis and the so-called reactive intravascular angioendotheliomatosis.

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Reactive intravascular histiocytosis associated with tonsillitis

Cited by 26 publications

References 10 publications

Incidental Simultaneous Finding of Intravascular Histiocytosis and Reactive Angioendotheliomatosis

Incidental Simultaneous Finding of Intravascular Histiocytosis and Reactive Angioendotheliomatosis

Pressure Bandage as an Effective Treatment for Intralymphatic Histiocytosis Associated with Rheumatoid Arthritis

Intralymphatic Histiocytosis. A Clinicopathologic Study of 16 Cases

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