Reactive nodular fibrous pseudotumor: A first report of gastric localization and clinicopathologic review

Torsed reactive nodular fibrous pseudotumor in an adolescent: case report and review of the literature

“…The first report described 5 such tumors in adults presenting in the alimentary tract and mesentery, with a microscopic appearance characterized by few spindle cells within a collagenous stroma [3]. More recent cases have been reported, and our case represents the 19th report of this lesion in the literature [4][5][6][7][8][9]. The age distribution in the literature is almost exclusively in adults (age range, 22-72 years) except for a single case in a 1-year-old boy [4].…”

“…These tumors generally arise in the setting of previous trauma or inflammation and, thus, represent an exuberant inflammatory response rather than a true neoplasm. Within the literature, RNFP has been associated with longstanding peptic ulcer [4,8], pancreatitis [3], duodenal diverticulum [6], endometriosis [7], foreign bodies [4], and postoperative adhesions [5]. In this patient, however, as well as a handful of others, the precise cause of RNFP remains unknown.…”

“…Gastrointestinal stromal tumor tends to be more cellular than RNFP and is immunopositive for both CD34 and CD117 [1]. Unlike other more aggressive lesions, RNFP has never been noted to recur after resection [3,4,8].…”

Torsion of omental fibrous pseudotumour mimicking acute appendicitis

“…It is postulated that these tumours may represent a late stage of inflammatory myofibroblastic tumour [ 2 ]. Fibrous pseudotumours have been reported to affect, among other sites, the tongue [ 3 ], scrotum [ 4 ], adrenal gland [ 5 ], extrahepatic bile ducts [ 6 ], stomach [ 7 , 8 ], gallbladder [ 9 ] and omentum [ 10 ]. To our knowledge, this is the first report of omental fibrous pseudotumours presenting as an acute abdomen due to acute torsion and infarction.…”

Reactive nodular fibrous pseudotumor involving the gastrointestinal tract and mesentery: A case report and review of the literature

“…Cases of RNFP arising within the abdominal cavity ( 6 , 7 ), including the GI tract ( 3 ), mesentery and retroperitoneum, are rare but important due to their propensity to be misdiagnosed as more aggressive types of tumor, such as metastatic malignant neoplasm, primary GIST or inflammatory myofibroblastic (IMF) tumor. The case presented in the present study was initially suspected to be a metastatic malignant tumor due to the presence of multiple diffuse nodules within the abdominal cavity.…”