Reactive Oxygen and Nitrogen Species: Interactions with Mitochondria and Pathophysiology

Zelickson, Blake R.; Ballinger, Scott W.; Dell’Italia, Louis J.; Zhang, J.; Darley‐Usmar, Victor

doi:10.1016/b978-0-12-378630-2.00414-x

Cited by 6 publications

(8 citation statements)

References 16 publications

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“…Reactive oxygen species (ROS) – partially reduced intermediates of oxygen that can be radical or non-radical molecules (Zelickson et al, 2013) – are generated during metabolism through a number of inter-related reactions Eqs. (1)–(4) (Novo and Parola, 2008) and are considered to lead to the cumulative DNA, protein and lipid damage (Piedrafita et al, 2015; Rinnerthaler et al, 2015; Thanan et al, 2014) (Fig.…”

Section: Theories Of Aging and How They Shape The Definitions Of Smentioning

confidence: 99%

“…Additionally, it has also been associated to impairments in sleep homeostasis (Rytkönen et al, 2010), psychological disorders (Maurya et al, 2016) and dementia (Mangialasche et al, 2009). However, the mechanisms by which RNS may interact with cellular components, such as the mitochondrion, are still unclear, particularly in vivo (Zelickson et al, 2013). Consequently, there is the need to better understand how these species are formed and the processes through which they affect mitochondrial and cellular function.…”

Section: Theories Of Aging and How They Shape The Definitions Of Smentioning

confidence: 99%

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A synopsis on aging—Theories, mechanisms and future prospects

Costa

Vitorino

Silva³

et al. 2016

Ageing Research Reviews

339

170

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Answering the question as to why we age is tantamount to answering the question of what is life itself. There are countless theories as to why and how we age, but, until recently, the very definition of aging – senescence – was still uncertain. Here, we summarize the main views of the different models of senescence, with a special emphasis on the biochemical processes that accompany aging. Though inherently complex, aging is characterized by numerous changes that take place at different levels of the biological hierarchy. We therefore explore some of the most relevant changes that take place during aging and, finally, we overview the current status of emergent aging therapies and what the future holds for this field of research. From this multi-dimensional approach, it becomes clear that an integrative approach that couples aging research with systems biology, capable of providing novel insights into how and why we age, is necessary.

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Section: Theories Of Aging and How They Shape The Definitions Of Smentioning

confidence: 99%

Section: Theories Of Aging and How They Shape The Definitions Of Smentioning

confidence: 99%

A synopsis on aging—Theories, mechanisms and future prospects

Costa

Vitorino

Silva³

et al. 2016

Ageing Research Reviews

339

170

View full text Add to dashboard Cite

show abstract

“…The action of adenylate kinase promoted the conversion of ATP to AMP and further into IMP and NH 3 molecules ( Longo, Lana, Bottero, & Zolla, 2015 ), which were negatively correlated with the freshness and quality of the muscle products. The GPDH enzyme located at the mitochondrial membrane in muscle tissues has been reported to produce O 2 ·- , a reactive oxygen species (ROS), during the transport of electrons from NADH to the electron transport chain ( Zelickson, Ballinger, Dell'Italia, Zhang, & Darleyusmar, 2013 ). This presumably accelerated the development of protein/lipid oxidation occurring in the high-fat hairtail muscle during cold storage.…”

Section: Resultsmentioning

confidence: 99%

Cold-induced denaturation of muscle proteins in hairtail (Trichiurus lepturus) during storage: Physicochemical and label-free based proteomics analyses

Shui

Yan

et al. 2022

Food Chemistry: X

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“…ROS and RNS at low levels contribute to cell signaling, mitochondrial respiration and biogenesis. However, when not properly controlled, high ROS and RNS levels cause DNA, lipid, and protein damage [ 42 ], and consequently, cell death may occur [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of in vitro anti-inflammatory effects of crude ginger and rosemary extracts obtained through supercritical CO2 extraction on macrophage and tumor cell line: the influence of vehicle type

Justo

Simioni

Gabriel

et al. 2015

BMC Complement Altern Med

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BackgroundNumerous plants from have been investigated due to their anti-inflammatory activity and, among then, extracts or components of ginger (Zingiber officinale Roscoe) and rosemary (Rosmarinus officinalis L.), sources of polyphenolic compounds. 6-gingerol from ginger rhizome and carnosic acid and carnosol from rosemary leaves present anti-tumor, anti-inflammatory and antioxidant activities. However, the evaluation of the mechanisms of action of these and other plant extracts is limited due to their high hydrophobicity. Dimethylsulfoxide (DMSO) is commonly used as a vehicle of liposoluble materials to mammalian cells in vitro, presenting enhanced cell penetration. Liposomes are also able to efficiently deliver agents to mammalian cells, being capable to incorporate in their structure not only hydrophobic molecules, but also hydrophilic and amphiphilic compounds. Another strategy is based on the use of Pluronic F-68, a biocompatible low-foaming, non-ionic surfactant, to disperse hydrophobic components. Here, these three delivery approaches were compared to analyze their influence on the in vitro anti-inflammatory effects of ginger and rosemary extracts, at different concentrations, on primary mammalian cells and on a tumor cell line.MethodsGinger and rosemary extracts free of organic solvents were obtained by supercritical fluid extraction and dispersed in DMSO, Pluronic F-68 or liposomes, in variable concentrations. Cell viability, production of inflammatory mediators and nitric oxide (NO) release were measured in vitro on J774 cell line and murine macrophages primary culture stimulated with bacterial lipopolysaccharide and interferon-γ after being exposed or not to these extracts.ResultsGinger and rosemary extracts obtained by supercritical CO2 extraction inhibited the production of pro-inflammatory cytokines and the release of NO by peritoneal macrophages and J774 cells. The delivery vehicles influenced the anti-inflammatory effects. Comparatively, the ginger extract showed the highest anti-inflammatory activity on the tumor cell line. Controversially, rosemary extract dispersed on DMSO induced a more significant IL-1 and TNF-α reduction than ginger extract in primary macrophages.ConclusionsAmongst the tested delivery vehicles, DMSO was the most suitable, presenting reduced cytotoxicity, followed by Pluronic F-68 and liposomes, provably due to differences in their form of absorption, distribution and cellular metabolism. Co-administration of liposomes and plant extracts may cause death of macrophages cells and induction of NO production. It can be concluded that some of the beneficial effects attributed to extracts of ginger and rosemary may be associated with the inhibition of inflammatory mediators due to their high antioxidant activity. However, these effects were influenced by the type of delivery vehicle.

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Reactive Oxygen and Nitrogen Species: Interactions with Mitochondria and Pathophysiology

Cited by 6 publications

References 16 publications

A synopsis on aging—Theories, mechanisms and future prospects

A synopsis on aging—Theories, mechanisms and future prospects

Cold-induced denaturation of muscle proteins in hairtail (Trichiurus lepturus) during storage: Physicochemical and label-free based proteomics analyses

Evaluation of in vitro anti-inflammatory effects of crude ginger and rosemary extracts obtained through supercritical CO2 extraction on macrophage and tumor cell line: the influence of vehicle type

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