Reactive Oxygen and Nitrogen Species in Carcinogenesis: Implications of Oxidative Stress on the Progression and Development of Several Cancer Types

Kruk, Joanna; Aboul‐Enein, Hassan Y.

doi:10.2174/1389557517666170228115324

Cited by 142 publications

(97 citation statements)

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“…Intracellular ROS may induce DNA damage and chromosome instability and activate apoptotic pathways to induce cancer cell death. 20 Several studies have reported that Que has an antioxidative effect that can quench ROS, reactive nitrogen species, and other radicals. 21,22 Li et al showed that low concentration of Que decreased the cytotoxic effect of cisplatin by reducing intracellular ROS in ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

<p>Quercetin Enhanced Paclitaxel Therapeutic Effects Towards PC-3 Prostate Cancer Through ER Stress Induction and ROS Production</p>

Zhang

Huang

et al. 2020

OTT

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Introduction: Prostate cancer is one of the most common cancers threatening public health worldwide. Although chemotherapy plays an important role in treating prostate cancer, it leads to many adverse effects and is prone to drug resistance. Quercetin, a natural product, is used in traditional Chinese medicine because of its strong antitumor activity and few side effects. Methods: In this study, we combined quercetin and paclitaxel to kill prostate cancer cells in vivo and in vitro, and we investigated the relevant mechanism of this combination treatment. After the cancer cells were treated with quercetin or/and paclitaxel, cell growth inhibition, apoptosis, the cell cycle, reactive oxygen species (ROS) generation, and several endoplasmic reticulum (ER) stress signaling pathway related gene expressions were evaluated. Results: The combined treatment with quercetin and paclitaxel significantly inhibited cell proliferation, increased apoptosis, arrested the cell cycle at the G2/M phase, inhibited cell migration, dramatically induced ER stress to occur, and increased ROS generation. In a PC-3 cancer-bearing murine model, this combination treatment exerted the most beneficial therapeutic effects, and quercetin increased the cancer cell-killing effects of paclitaxel, with nearly no side effects compared with the single paclitaxel treatment group. Conclusion: Combination treatment possessed enhanced anti-cancer effects, and these results will provide a basis for treating prostate cancer using a combination of quercetin and paclitaxel.

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Section: Discussionmentioning

confidence: 99%

<p>Quercetin Enhanced Paclitaxel Therapeutic Effects Towards PC-3 Prostate Cancer Through ER Stress Induction and ROS Production</p>

Zhang

Huang

et al. 2020

OTT

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“…Oxidative stress has been considered as a major contributor to the development of skin cancers, such as melanoma [144][145][146]. Accordingly, antioxidants, including resveratrol, have been used to prevent and treat skin cancer [147][148][149], although exacerbation and increased risk of cancers have been reported [150,151]. Melanoma is the most serious type of skin cancer, with mortality rates of 3.1/100,000 in the US [152] and 1.4-1.9/100,000 in Germany [153].…”

Section: Anticancermentioning

confidence: 99%

Role of Resveratrol in Regulating Cutaneous Functions

Wen

Zhang

Yang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Protective role of the skin is against external insults and maintenance of electrolyte homeostasis of the body. Cutaneous dysfunction can account for the development of both cutaneous and systemic disorders. Thus, improvements in cutaneous functions can benefit a number of extracutaneous and cutaneous functions. Resveratrol, a natural ingredient, displays multiple benefits for various systems/organs, including the skin. The benefits of resveratrol for cutaneous functions include stimulation of keratinocyte differentiation and antimicrobial peptide expression, inhibition of keratinocyte proliferation and cutaneous inflammation, UV protection, anticancer, antiaging, and inhibition of melanogenesis. The mechanisms of action of resveratrol include activation of sirtuin 1 and nuclear factor erythroid 2-related factor 2, and inhibition of mitogen-activated protein kinase signaling. Evidence suggests that topical resveratrol could be a valuable alternative not only for daily skin care, but also for the prevention and treatment of various cutaneous disorders. This review summarizes the benefits of resveratrol for cutaneous functions.

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“…In addition to ROS, other reactive species have notable impacts on redox biology and, consequently, on oxidative stress. These include the reactive nitrogen species (RNS) [starting with the reaction of nitric oxide Brought to you by | University of California -Irvine Authenticated Download Date | 5/4/19 12:43 AM (˙NO) with O 2˙− to form peroxynitrite (ONOO − ), Figure 1] (Kruk and Aboul-Enein, 2017), reactive sulfur species (RSS) (i.e. persulfides, polysulfides and thiosulfate, which can oxidize and inhibit thiol-proteins and enzymes) (Nishida et al, 2016), reactive carbonyl species (RCS) (i.e.…”

Section: Oxidative Stress and The Intracellular Redox State In Melanomentioning

confidence: 99%

Oxidative stress and antioxidants in the pathophysiology of malignant melanoma

Obrador

Liu‐Smith

Dellinger

et al. 2018

Biological Chemistry

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Reactive Oxygen and Nitrogen Species in Carcinogenesis: Implications of Oxidative Stress on the Progression and Development of Several Cancer Types

Cited by 142 publications

References 0 publications

<p>Quercetin Enhanced Paclitaxel Therapeutic Effects Towards PC-3 Prostate Cancer Through ER Stress Induction and ROS Production</p>

<p>Quercetin Enhanced Paclitaxel Therapeutic Effects Towards PC-3 Prostate Cancer Through ER Stress Induction and ROS Production</p>

Role of Resveratrol in Regulating Cutaneous Functions

Oxidative stress and antioxidants in the pathophysiology of malignant melanoma

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