Reactive oxygen species a double-edged sword for mesothelioma

Abstract

It is well known that oxidative stress can lead to chronic inflammation which, in turn, could mediate most chronic diseases including cancer. Oxidants have been implicated in the activity of crocidolite and amosite, the most powerful types of asbestos associated to the occurrence of mesothelioma. Currently rates of mesothelioma are rising and estimates indicate that the incidence of mesothelioma will peak within the next 10–15 years in the western world, while in Japan the peak is predicted not to occur until 40 years from now. Although the use of asbestos has been banned in many countries around the world, production of and the potentially hazardous exposure to asbestos is still present with locally high incidences of mesothelioma. Today a new man-made material, carbon nanotubes, has arisen as a concern; carbon nanotubes may display ‘asbestos-like’ pathogenicity with mesothelioma induction potential. Carbon nanotubes resulted in the greatest reactive oxygen species generation. How oxidative stress activates inflammatory pathways leading to the transformation of a normal cell to a tumor cell, to tumor cell survival, proliferation, invasion, angiogenesis, chemoresistance, and radioresistance, is the aim of this review.

Progress and challenges in Mesothelioma: From bench to bedside

“…Indeed, the mutation signature of smoke-related DNA-damage was entirely absent, suggesting that smoking does not contribute to MPM. Instead, a reactive oxygen species (ROS)-induced DNA damage signature predominated, consistent with the known effects of asbestos fibres and macrophagedriven inflammation [87].…”

“…Unlike screening, chemoprophylaxis does not require development of expensive diagnostic tools but could utilise similar lifetime MPM risk models [109] to identify those most likely to benefit. MPM is typically preceded by decades of chronic asbestos-related inflammation and the production of ROS [87], which in turn has recently been associated with the common genetic lesions found in MPM tumours [22]. However, previous studies using plausible chemoprophylactic agents have been disappointing.…”

An overview on the role of dietary phenolics for the treatment of cancers

“…The free radicals produced in cells during oxidative stress are highly reactive and capable of inducing tissue damage by reacting with membrane lipids, nucleotides, sulphydryl groups of proteins and by cross-linking/fragmentation of ribonucleoproteins [96]. As a result of these ROS induced insults, the cells undergo transformation and form a variety of tumors [97]. ROS generated in the cancer cells are involved in activation of several transcription factors including the NF-kβ, STAT3, activator protein-1 etc.…”

Hydrogen Peroxide Enhances TGFβ-mediated Epithelial-to-Mesenchymal Transition in Human Mammary Epithelial MCF-10A Cells

“…Increased ROS levels have been observed in many types of tumor cells, suggesting that they contribute to tumorigenesis and tumor metastasis (9,10). Mesothelioma is caused by inhalation of asbestos fibers, which results in higher ROS levels and EMT induction (11,12). These observations suggest that tumorigenesis is associated with the interaction of ROS and EMT.…”