Reactive Oxygen Species&amp; Its Role in Periodontal Disease

Bhusari, Bansi M; Mahajan, Ridhima; Rajbhoj, Shubhangi; Shah, Pooja

doi:10.9790/0853-13815259

Cited by 10 publications

(8 citation statements)

References 19 publications

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“…Therefore, through the nuclear factor-κB system, it can cause inflammation in the periodontal tissue, which increases the incidence of gingivitis. 61,62…”

Section: Gingivitis In Patients With Beta Thalassemia Majormentioning

confidence: 99%

Effects of Iron Accumulation on Dental Caries, Gingivitis, and Candida albicans Infection in Children with Beta Thalassemia Major: A Narrative Review

2022

Acta Med Philipp

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“…Therefore, through the nuclear factor-κB system, it can cause inflammation in the periodontal tissue, which increases the incidence of gingivitis. 61,62…”

Section: Gingivitis In Patients With Beta Thalassemia Majormentioning

confidence: 99%

Effects of Iron Accumulation on Dental Caries, Gingivitis, and Candida albicans Infection in Children with Beta Thalassemia Major: A Narrative Review

2022

Acta Med Philipp

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“…During normal metabolism, osteoclasts, platelets, lymphocytes, neutrophils, monocytes and fibroblasts can induce the formation of ROS [32,33]. When in excess, these ROSs can trigger damage to cellular constituents, extracellular components and affect the metabolism of the cells responsible for extracellular matrix synthesis-fundamental in tissue repair-which leads to apoptosis and cellular necrosis [34,35].…”

Section: Stagementioning

confidence: 99%

A Systematic Review of Oxygen Therapy for the Management of Medication-Related Osteonecrosis of the Jaw (MRONJ)

et al. 2019

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Background: Medication-related osteonecrosis of the jaw (MRONJ) can be a life changing iatrogenic complication of antiresorptive and antiangiogenic drug therapy. It is most often associated with high doses of these medications that are used to prevent skeletal-related events in patients with cancer and bone pathologies. Unfortunately, managing MRONJ lesions has proven difficult and remains a major challenge for clinicians. Due to the lack of efficacy in treating MRONJ by surgical modalities (local debridement and free flap reconstruction), the nonsurgical management of MRONJ is still advocated to aid healing or avoid disease progression. The aim of this systematic review is to identify, analyse and understand the published evidence related to the success of oxygen therapies such as ozone (OT) and hyperbaric oxygen (HBO) in treating MRONJ. Material and methods: A multi-database (PubMed, MEDLINE, EMBASE, CINAHL and Cochrane CENTRAL) systematic search was performed by three authors. The identified articles were independently assessed for their risk of bias. Any type of study evaluating humans treated with antiresorptive and antiangiogenic drugs were considered. The aim is primarily to evaluate the success of OT and HBO in resolving MRONJ and secondarily to identify any improvements in quality of life (QoL), rate of complications, time-to-event and severity of side effects related to these treatments. Results: In total, just 13 studies were eligible for analysis. A pooled total of 313 patients (HBO group n = 82; OT group n = 231) described in these studies have shown good tolerance for oxygen therapies. Complete resolution of MRONJ was reported in 44.58% of OT patients but only 5.17% of the HBO group. Progression of MRONJ was reported only in the HBO studies in 10.34% of cases (6 patients). The quality of evidence was low or very low in all studies. This was due to limitations in how the studies were designed, run and reported. Conclusions: Based on the limited data available, it is difficult to suggest OT is better or worse than HBO or whether it is better than a placebo. As the level of evidence available is low, this necessitates larger well-designed trials to justify these interventions for patients affected by MRONJ.

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“…Under normal circumstances, the pathogens are taken care of, and the tissue can be repaired. [ 2 ] However, in chronic inflammatory diseases, like periodontal disease,[ 3 ] low-grade inflammation causes persistent activation of inflammatory cells, resulting in a high degree of ROS release. Overproduced ROS deplete endogenous antioxidants, increase oxidative damage, and impair healing.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the effects of hydrogen water on human gingival fibroblast cell culture in patients with chronic periodontitis

Bhatt

Nayak

Bhat

et al. 2023

Journal of Indian Society of Periodontology

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Background: Activated inflammatory cells produce reactive oxygen species (ROS) to eliminate pathogens. Under normal conditions, the pathogens are taken care of, and tissues are repaired. However, in periodontal disease, persistent inflammation causes increased ROS release and impaired healing. Therefore, removal of overproduced ROS using antioxidants is necessary. Hydrogen water has an antioxidative effect on cells and impedes oxidative stress-related disorders. Aim: To study the effect of hydrogen water on cell viability, migration, and its antioxidative potential in fibroblasts obtained from chronic periodontitis patients. Materials and Methods: The gingival tissue samples were obtained from 26 subjects (13 periodontally healthy individuals and 13 chronic periodontitis patients) and processed. The human gingival fibroblasts were cultured and the assays were commenced once adequate growth was detected. The effect of hydrogen water on cell viability was checked by neutral red assay, while the migration potential was assessed by transwell migration assay. The antioxidative potential of hydrogen water was evaluated by CUPRAC assay. Statistical Analysis: Intergroup comparison was done using Mann–Whitney U -test. Intragroup comparison was done using Wilcoxon signed-rank test. Results: Hydrogen water was nontoxic to the fibroblasts at 24 h and 48 h. The intergroup comparison of the cell viability between hydrogen water-treated periodontally healthy gingival fibroblasts (HF) and fibroblasts from patients with chronic periodontitis (CF) showed a statistically significant ( P = 0.00) difference at 24 h and 48 h. Hydrogen water also positively influenced the migratory capacity. Hydrogen water-treated fibroblasts obtained from chronic periodontitis patients showed more migration in comparison to the healthy group ( P = 0.00). Hydrogen water showed an antioxidative potential. The maximum potential was seen in relation to the fibroblasts obtained from chronic periodontitis patients at 48 h. Conclusion: Hydrogen water was nontoxic, increased the migratory capacity, and showed an antioxidative potential on human fibroblasts obtained from periodontally healthy individuals and patients with chronic periodontitis.

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Reactive Oxygen Species& Its Role in Periodontal Disease

Cited by 10 publications

References 19 publications

Effects of Iron Accumulation on Dental Caries, Gingivitis, and Candida albicans Infection in Children with Beta Thalassemia Major: A Narrative Review

Effects of Iron Accumulation on Dental Caries, Gingivitis, and Candida albicans Infection in Children with Beta Thalassemia Major: A Narrative Review

A Systematic Review of Oxygen Therapy for the Management of Medication-Related Osteonecrosis of the Jaw (MRONJ)

Assessment of the effects of hydrogen water on human gingival fibroblast cell culture in patients with chronic periodontitis

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