2021
DOI: 10.3390/antiox10101537
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Reactive Oxygen Species and Antioxidative Defense in Chronic Obstructive Pulmonary Disease

Abstract: The respiratory system is continuously exposed to endogenous and exogenous oxidants. Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of the airways, leading to the destruction of lung parenchyma (emphysema) and declining pulmonary function. It is increasingly obvious that reactive oxygen species (ROS) and reactive nitrogen species (RNS) contribute to the progression and amplification of the inflammatory responses related to this disease. First, we described the association… Show more

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Cited by 43 publications
(53 citation statements)
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References 174 publications
(283 reference statements)
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“…For example, the severity of COVID-19 patients is affected by oxidative stress [ 10 ]. Excessive NO and ROS will destroy lipids, proteins and DNA in cells, and damage the normal function of tissues [ 11 , 12 ]. In order to reduce the risk of inflammation-related diseases, it is of great significance to suppress dysregulated inflammatory response.…”
Section: Introductionmentioning
confidence: 99%
“…For example, the severity of COVID-19 patients is affected by oxidative stress [ 10 ]. Excessive NO and ROS will destroy lipids, proteins and DNA in cells, and damage the normal function of tissues [ 11 , 12 ]. In order to reduce the risk of inflammation-related diseases, it is of great significance to suppress dysregulated inflammatory response.…”
Section: Introductionmentioning
confidence: 99%
“…). As such, oxidants have been shown to fuel inflammation, the protease-to-antiprotease imbalance, mucus metaplasia and mucin overexpression, and steroid resistance, and can be linked to the production of auto-antibodies, as reviewed in this Special Issue [3][4][5]10].…”
mentioning
confidence: 99%
“…As such, oxidative stress has been identified in lung tissue samples, as well as in samples of systemic bodily compartments in the form of end products of the oxidation of lipids, proteins and DNA (e.g., malondialdehyde, 4-hydroxynonenal, thiobarbituric acid-reactive substances, protein carbonyls and 8-hydroxy-2-deoxyguanosine) in multiple studies. Because they are relatively easy to measure, these oxidation products have been examined as non-invasive disease biomarkers [ 3 , 4 ].…”
mentioning
confidence: 99%
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