Reactive oxygen species and glutathione dual redox-responsive micelles for selective cytotoxicity of cancer

Chiang, Yen-Ting; Yen, Yu Wei; Lo, Chun Liang

doi:10.1016/j.biomaterials.2015.05.007

Cited by 135 publications

(88 citation statements)

References 39 publications

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“…Recently, Lo et al evaluated the potential of thioether‐based ROS‐responsive drug delivery systems at in vivo level ( Figure 7 ). 44 They developed a dual redox responsive polymer composed of hydrophilic methoxy PEG and hydrophobic block response to H 2 O 2 and GSH. The thioether and disulfide bonds were employed to impart the oxidation‐ and reduction‐responsiveness, respectively.…”

Section: Ros‐triggered Drug Release From Polymeric Nanoparticlesmentioning

confidence: 99%

Reactive‐Oxygen‐Species‐Responsive Drug Delivery Systems: Promises and Challenges

2016

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Given the increasing evidence indicates that many pathological conditions are associated with elevated reactive oxygen species (ROS) levels, there have been growing research efforts focused on the development of ROS‐responsive carrier systems because of their promising potential to realize more specific diagnosis and effective therapy. By judicious utilization of ROS‐responsive functional moieties, a wide range of carrier systems has been designed for ROS‐mediated drug delivery. In this review article, insights into design principle and recent advances on the development of ROS‐responsive carrier systems for drug delivery applications are provided alongside discussion of their in vitro and in vivo evaluation. In particular, the discussions in this article will mainly focus on polymeric nanoparticles, hydrogels, inorganic nanoparticles, and activatable prodrugs that have been integrated with diverse ROS‐responsive moieties for spatiotemporally controlled release of drugs for effective therapy.

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Section: Ros‐triggered Drug Release From Polymeric Nanoparticlesmentioning

confidence: 99%

Reactive‐Oxygen‐Species‐Responsive Drug Delivery Systems: Promises and Challenges

2016

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“…Similarly, Zhu and co‐workers developed a hyper‐branched polyglycerol (HPG) using a thioether linkage, which formed an H 2 O 2 ‐triggered polymeric micelle to deliver 7‐ethyl‐10‐hydroxy‐camptothecin (SN38) and cinnamaldehyde (CA) to cancer cells (MCF‐7, HeLa and HN‐4). Lo and co‐workers evaluated the potential of thioether‐based drug delivery systems in vivo with tumor‐bearing mice using a redox polymer consisting of the hydrophilic methoxy PEG and a hydrophobic block. The polymer contained a thioether bond for H 2 O 2 activation and disulfide bonds for GSH activation.…”

Section: Ros‐activated Drug Delivery and Small‐molecular Prodrug Systemsmentioning

confidence: 99%

Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

et al. 2019

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Reactive oxygen species (ROS) consist of a diverse range of oxidative small molecular ions and free radicals that are produced throughout the body during certain biological processes. Due to their high reactivity, these molecules result in the damage of tissues and cells. Therefore, ROS have been implicated in an array of diseases including cancer, inflammation, and neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Owing to the simplicity, sensitivity, and selectivity of fluorescence‐based strategies, many small‐molecular sensors or imaging agents have been developed to sense and visualize ROS both in vitro and in vivo. Likewise, activatable drug delivery and prodrug systems that can be triggered by ROS for disease theranostics (diagnostic and therapeutic combined) have been developed. Herein, recently developed fluorescence‐based sensing and imaging agents for the detection of ROS both intracellularly and in vivo are summarized. In addition, drug delivery, which require activation by ROS to achieve disease theranostics is also discussed.

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“…ROS is an important indicator and a major characteristic of several pathological conditions, including cancer, where elevated intracellular levels have been reported in disease conditions . ROS‐responsive drug delivery carriers currently being developed mostly involve organochalcogens (selenium, tellurium, diselenium, and ditellurium), organoboron compounds (aryl boronic ester), sulfur containing compounds (thioether, thioketal, vinyl dithioether), aryl oxalates, and ferrocenes, either as cross‐linkers or as important constituents of polymeric backbone. Although very few studies have been reported for ROS‐responsive nanogels, it would be worthwhile to review some of the important reported results, due to the potential applicability of the ROS‐responsive units in the development of advanced redox‐responsive nanogel‐based systems in the near future.…”

Section: Emerging Areas In the Field Of Redox‐responsive Materialsmentioning

confidence: 99%

A Comprehensive Outlook of Synthetic Strategies and Applications of Redox‐Responsive Nanogels in Drug Delivery

Kumar

Liu

Behl

2019

Macromolecular Bioscience

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Increasing recognition of the role of oxidative stress in the pathogenesis of many clinical conditions and the existence of defined redox potential in healthy tissues has led to extensive research in the development of redox‐responsive materials for biomedical applications. Especially, considerable growth has been seen in the fabrication of polymeric nanogel–based drug delivery carriers utilizing redox‐responsive cross‐linkers bearing a variety of functional groups via various synthetic strategies. Redox‐responsive polymeric nanogels provide an advantage of facile chemical modification post synthesis and exhibit a remarkable response to biological redox stimuli. Due to the interdisciplinary nature of the subject, a more profound combined conceptual knowledge from a chemical and biological point of view is imperative for the rational design of redox‐responsive nanogels. The present review provides an insight into the design and fabrication of redox‐responsive nanogels with particular emphasis on synthetic strategies utilized for the development of redox‐responsive cross‐linkers, polymerization techniques being followed for nanogel development and biomedical applications. Cooperative effect of redox trigger with other stimuli such as pH and temperature in the evolution of dual and triple stimuli‐responsive nanogels is also discussed.

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Reactive oxygen species and glutathione dual redox-responsive micelles for selective cytotoxicity of cancer

Cited by 135 publications

References 39 publications

Reactive‐Oxygen‐Species‐Responsive Drug Delivery Systems: Promises and Challenges

Reactive‐Oxygen‐Species‐Responsive Drug Delivery Systems: Promises and Challenges

Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

A Comprehensive Outlook of Synthetic Strategies and Applications of Redox‐Responsive Nanogels in Drug Delivery

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