Reactive oxygen species and glutathione dual responsive nanoparticles for enhanced prostate cancer therapy

Zhang, Liuhui; Zhang, Shiqiang; Li, Mengxiong; Li, Yamei; Xiong, Haiyun; Jiang, Donggen; Huang, Hai; Kang, Yang; Pang, Jun

doi:10.1016/j.msec.2021.111956

Cited by 25 publications

(13 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Docetaxel (DTX) is an antitumor drug [ 1 , 2 ] and plays an important role in the treatment of breast cancer [ 3 ] and prostate cancer [ 4 ], among others. However, it has different degrees of similar side effects to some chemotherapeutic drugs, such as pericardial effusion [ 5 ], fluid retention [ 6 ] and radiation recall dermatitis (RRD) [ 7 ], which all can affect the treatment outcome.…”

Section: Introductionmentioning

confidence: 99%

The Fabrication of Docetaxel-Containing Emulsion for Drug Release Kinetics and Lipid Peroxidation

Wang

et al. 2022

Pharmaceutics

View full text Add to dashboard Cite

Docetaxel (DTX)-based formulation development is still confronted with significant challenges, due to its refractory solubility and side effects on normal tissues. Inspired by the application of the transdermal drug delivery model to topical treatment, we developed a biocompatible and slow-release DTX-containing emulsion via self-assembly prepared by a high-speed electric stirring method and optimized the formulation. The results of accelerated the emulsion stability experiment showed that the emulsion prepared at 10,000 rpm/min had a stability of 89.15 ± 2.05%. The ADME, skin irritation, skin toxicity and molecular interaction between DTX and excipients were predicted via Discovery Studio 2016 software. In addition, DTX addition in oil or water phases of the emulsion showed different release rates in vitro and ex vivo. The DTX release ex vivo of the DTX/O-containing emulsion and the DTX/W-containing emulsion were 45.07 ± 5.41% and 96.48 ± 4.54%, respectively. In vitro antioxidant assays and anti-lipid peroxidation models revealed the antioxidant potential of DTX. However, DTX-containing emulsions could maintain and even enhance the antioxidant effect, both scavenging free radicals in vitro and inhibiting the process of lipid peroxidation.

show abstract

Section: Introductionmentioning

confidence: 99%

The Fabrication of Docetaxel-Containing Emulsion for Drug Release Kinetics and Lipid Peroxidation

Wang

et al. 2022

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Preparation and Characterization of Poly(Cys-Cys-TK) NPs and THPP@NPs: The detailed methods were previously reported. [2] Nanoprecipitation was used to fabricate both the NPs and THPP@NPs. The polymers, poly(Cys-Cys-TK) (20.0 mg) and THPP (5.0 mg), were dissolved in 1 mL of DMSO.…”

Section: Methodsmentioning

confidence: 99%

“…[1] In our previous studies, we verified the higher basal levels of intracellular reactive oxygen species (ROS) in prostate cell lines. [2,3] Antitumor strategies that include exposing inner tumor tissues to ROS have been explored over the platforms with outstanding performance may improve the therapy of advanced PCa. Herein, we designed and synthesized redoxsensitive nanoparticles (NPs) that encapsulate the sonosensitizer 5,10,15,20-tetrakis (4-hydroxyphenyl)porphyrin (THPP).…”

Section: Introductionmentioning

confidence: 99%

Effective Sonosensitizer Delivery by Redox Sensitive Nanoparticles for Prostate Cancer Sonodynamic Therapy via Amplifying Oxidative Stress and Peroxidation

Tong

Lei

Zhang

et al. 2022

Adv Healthcare Materials

Self Cite

View full text Add to dashboard Cite

Sonodynamic therapy (SDT), a novel noninvasive therapeutic modality, provides many noteworthy benefits by generating reactive oxygen species (ROS). However, water-insoluble sonosensitizer delivery strategies have continuously underperformed because of unavoidable toxicity and a short circulation time. In this study, l-cystine derivative-based biocompatible nanoparticles (NPs) that can be used in SDT and induce limited cytotoxicity are designed and synthesized. After ultrasonic (US) irradiation, these sonosensitizer-loaded NPs show highly efficient sonodynamic performance that leads to cytotoxic ROS production. The ability to stop and start ROS generation induced by US irradiation enables accurate temporal and spatial control. In vivo and in vitro experiments are systematically performed to investigate the effects of this system on tumors, and the results indicate remarkable tumor suppression via markedly high persistent oxidative stress that induces peroxidation and endoplasmic reticulum stress. Thus, this novel temporally and spatially controllable ROS generation platform offers a safe and effective theranostic strategy for prostate cancer treatment.

show abstract

“…Due to the high GSH and ROS levels, such conversion is extremely typically investigated in cancer therapy. In organisms, reduced GSH and oxidized H2O2 in acid atmosphere could help to realize the conversion [93,94]. One of the important products in this conversion is toxic •OH.…”

Section: Table I Stimulus Responsive Units Based Onmentioning

confidence: 99%

The Role of Cyclodextrin in the Construction of Nanoplatforms: From Structure, Function and Application Perspectives

Chen¹,

Zheng²,

Tian³

et al. 2023

Preprint

View full text Add to dashboard Cite

Drug delivery systems consist of cyclodextrins (CyDs) have kept constant attention for good compatibility, negligible toxicity, and improved pharmacokinetics of drugs. The unique hollow structure has endowed a lot of functions, such as inclusion of guest molecules, functional modification of active hydroxyl groups, and noncovalent interactions. Besides, the polyhydroxy structure has further extended the functions of CyDs by inter/intramolecular interactions and chemical modification. Furthermore, the versatile functions of the complex contribute to physicochemical characteristics alteration of the drugs, therapeutic talent, stimulus-responsive switch, self-assemble capability, and fiber formation. This review attempts to list the recent progress of CyDs and discuss their roles in the drug delivery system. Future perspectives of the construction of CyD-based drug delivery systems are also discussed at the end of this review, which may be the possible directions for the construction of more rational and cost-effective delivery vehicles.

show abstract

Reactive oxygen species and glutathione dual responsive nanoparticles for enhanced prostate cancer therapy

Cited by 25 publications

References 43 publications

The Fabrication of Docetaxel-Containing Emulsion for Drug Release Kinetics and Lipid Peroxidation

The Fabrication of Docetaxel-Containing Emulsion for Drug Release Kinetics and Lipid Peroxidation

Effective Sonosensitizer Delivery by Redox Sensitive Nanoparticles for Prostate Cancer Sonodynamic Therapy via Amplifying Oxidative Stress and Peroxidation

The Role of Cyclodextrin in the Construction of Nanoplatforms: From Structure, Function and Application Perspectives

Contact Info

Product

Resources

About