Reactive oxygen species and mitogen-activated protein kinase induce apoptotic death of SH-SY5Y cells in response to fipronil

Ki, Yeo Woon; Lee, Jeong Eun; Park, Jae Hyeon; Shin, In Chul; Koh, Hyun Chul

doi:10.1016/j.toxlet.2012.02.022

Cited by 62 publications

(43 citation statements)

References 60 publications

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“…95 Cultured neuroblastoma cells (SH-SY5Y) exposed to fipronil, a phenylpyrazole insecticide, exhibited elevated amounts of ROS and were more likely to undergo apoptosis (cell suicide) compared with untreated cells. 96 Apoptosis was found to correlate with the extent of oxidative stress caused by the fipronil. Thus, these representative descriptive reports do suggest that pesticides can enhance levels of ROS in cultured cells.…”

Section: Cell-based and Animal Studies To Establish Biomarkers Of Pesmentioning

confidence: 98%

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Increased cancer burden among pesticide applicators and others due to pesticide exposure

Alavanja

Ross

Bonner

2013

CA A Cancer J Clinicians

297

213

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A growing number of well-designed epidemiological and molecular studies provide substantial evidence that the pesticides used in agricultural, commercial, and home and garden applications are associated with excess cancer risk. This risk is associated both with those applying the pesticide and, under some conditions, those who are simply bystanders to the application. In this article, the epidemiological, molecular biology, and toxicological evidence emerging from recent literature assessing the link between specific pesticides and several cancers including prostate cancer, non-Hodgkin lymphoma, leukemia, multiple myeloma, and breast cancer are integrated. Although the review is not exhaustive in its scope or depth, the literature does strongly suggest that the public health problem is real. If we are to avoid the introduction of harmful chemicals into the environment in the future, the integrated efforts of molecular biology, pesticide toxicology, and epidemiology are needed to help identify the human carcinogens and thereby improve our understanding of human carcinogenicity and reduce cancer risk. CA Cancer J Clin 2013;63:120-142.

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Section: Cell-based and Animal Studies To Establish Biomarkers Of Pesmentioning

confidence: 98%

“…95,96 In addition, DNA single-strand breaks were also elevated in the livers and brains of pesticide-treated rats. Thus, oxidative stress can be elicited in cultured cells and intact animals by pesticides that have very different chemical structures.…”

Section: Cell-based and Animal Studies To Establish Biomarkers Of Pesmentioning

confidence: 99%

Increased cancer burden among pesticide applicators and others due to pesticide exposure

Alavanja

Ross

Bonner

2013

CA A Cancer J Clinicians

297

213

View full text Add to dashboard Cite

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“…Fipronil shows a higher affinity for insect than mammalian transmitter receptors [1][2][3]. However, a few studies have suggested that fipronil toxicity, such as the apoptotic death of the oocytes of Rhipicephalus sanguineus [4], disruption of thyroid function in rats [5], and cytotoxicity in human hepatocytes [6], Caco-2 cells [7] and human neuroblastoma SH-SY5Y cells [5,8,9], exists independently of its neural target. Research on SH-SY5Y cells indicated that fipronil potentially induced mitochondrial collapse, Cytochrome c release, caspase-3 activation and oxidative stress associated with neuronal cell death.…”

Section: Introductionmentioning

confidence: 99%

Fipronil induces apoptosis through caspase-dependent mitochondrial pathways in Drosophila S2 cells

Zhang

et al. 2015

Pesticide Biochemistry and Physiology

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“…Calreticulin binds to misfolded proteins, preventing them from being exported from the endoplasmic reticulum to the Golgi apparatus (Michalak et al 2012), whereas the lethal protein Efl21 is related to the heat shock protein family, playing the role of a chaperonin (Kurzik-Dumke and Lohmann 1995). According to Ki et al (2012), oxidative stress plays a central role in fipronil-induced cytotoxicity. Thus, both proteins are likely related to neuronal protection against protein misfolding that is caused by fipronil-induced chemical stress in the neuronal soma.…”

Section: Discussionmentioning

confidence: 99%

Modification of the brain proteome of Africanized honeybees (Apis mellifera) exposed to a sub‐lethal doses of the insecticide fipronil

et al. 2014

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Fipronil is a phenylpyrazole insecticide that is widely used in Brazilian agriculture for pest control. Although honeybees are not targets of fipronil, studies indicate that this pesticide can be harmful to honeybees. To assess the effects of fipronil in the brain of Africanized Apis mellifera workers, this study focused on the toxico-proteome profiling of the brain of newly emerged and aged honeybee workers that were exposed to a sub-lethal dose (10 pg fipronil per day. i.e. (1)/100 of LD50/bee/day during 5 days) of the insecticide. Proteomic analysis identified 25 proteins that were differentially up-regulated or down-regulated when the fipronil-exposed and non-exposed groups were compared. These proteins are potentially related to pathogen susceptibility, neuronal chemical stress, neuronal protein misfolding, and occurrence of apoptosis, ischemia, visual impairment, damaged synapse formation, brain degeneration, memory and learning impairment. The exposure of honeybees to a very low dose of fipronil, even for a short period of time (5 days), was sufficient to cause a series of important neuroproteomic changes in the brains of honeybees.

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Reactive oxygen species and mitogen-activated protein kinase induce apoptotic death of SH-SY5Y cells in response to fipronil

Cited by 62 publications

References 60 publications

Increased cancer burden among pesticide applicators and others due to pesticide exposure

Increased cancer burden among pesticide applicators and others due to pesticide exposure

Fipronil induces apoptosis through caspase-dependent mitochondrial pathways in Drosophila S2 cells

Modification of the brain proteome of Africanized honeybees (Apis mellifera) exposed to a sub‐lethal doses of the insecticide fipronil

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