1998
DOI: 10.1161/01.hyp.32.6.1003
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Reactive Oxygen Species Are Critical in the Oleic Acid–Mediated Mitogenic Signaling Pathway in Vascular Smooth Muscle Cells

Abstract: Abstract-Obese hypertensive patients with cardiovascular risk factor clustering have increased plasma nonesterified fatty acid levels and are at high risk for atherosclerotic events. Our previous studies demonstrated that oleic acid induces a mitogenic response in rat aortic smooth muscle cells (RASMCs) through protein kinase C (PKC)-and extracellular signal-regulated kinase (ERK)-dependent pathways. In the present study we investigated the possibility that the generation of reactive oxygen species (ROS) const… Show more

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Cited by 75 publications
(50 citation statements)
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“…OA is a principal fatty acid in triglycerides and has its highest concentration in plasma. Several reports demonstrate that OA may induce proliferation and migration of SMC via sequential signaling pathways, including activation of PKC, ERK and PI3K, and generation of reactive oxygen species (13)(14)(15). In our present study, VSMC proliferation was induced by the stimulation of OA at concentrations of 10 to 150 µM.…”
Section: Discussionsupporting
confidence: 60%
“…OA is a principal fatty acid in triglycerides and has its highest concentration in plasma. Several reports demonstrate that OA may induce proliferation and migration of SMC via sequential signaling pathways, including activation of PKC, ERK and PI3K, and generation of reactive oxygen species (13)(14)(15). In our present study, VSMC proliferation was induced by the stimulation of OA at concentrations of 10 to 150 µM.…”
Section: Discussionsupporting
confidence: 60%
“…16 In vitro studies support the notion that NEFAs can induce oxidant stress. 48 In vivo, elevation of NEFAs with Intralipid and heparin infusions has been shown to increase the concentrations of various biomarkers of oxidant stress. 49,50 On the other hand, the contribution of oxidant stress in hypertension development is supported by preliminary animal data, 51 and indirect evidence from studies where diet rich in fruits and vegetables, containing high amounts of antioxidant substances, significantly reduced BP.…”
Section: Nefa and Oxidant Stressmentioning
confidence: 99%
“…Activation of ERK and PI 3-kinase has been shown to be required for vascular smooth muscle proliferation (122)(123)(124), and inhibition of proliferation by cAMP occurs via suppression of cyclin D 1 expression (125,126), as it does in airway smooth muscle (87). Finally, reactive oxygen species may be critical for vascular smooth muscle cell mitogenic signaling (127,128), as they are in airway myocytes (79). Perhaps these species and tissue similarities are to be expected, as many aspects of MAP kinase cascades, GTPase signaling pathways and cell cycle regulation are highly conserved in eukaryotic species, including mammals, Drosophila, nematodes and yeast (129)(130)(131)(132)(133)(134)(135).…”
Section: Perspectivementioning
confidence: 99%