Reactive oxygen species are involved in nickel inhibition of DNA repair

Lynn, Shugene; Yew, F. H.; Chen, K. S.; Jan, K. Y.

doi:10.1002/(sici)1098-2280(1997)29:2<208::aid-em11>3.0.co;2-i

Cited by 68 publications

(17 citation statements)

References 53 publications

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“…Nickel exposed cells have a reduced GSH, which is a marker of oxidative stress [168]. Depletion of glutathione significantly enhances nickelinduced apoptosis [169]. Recently a few laboratories have contributed to Ni-induced apoptosis.…”

Section: Apoptosismentioning

confidence: 99%

Metals and apoptosis: Recent developments

Rana

2008

Journal of Trace Elements in Medicine and Biology

333

175

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Section: Apoptosismentioning

confidence: 99%

Metals and apoptosis: Recent developments

Rana

2008

Journal of Trace Elements in Medicine and Biology

333

175

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“…However, it is known to be a calcium channel blocker (Lee et al 1999, Zamponi et al 1996 leading to changes on intracellular concentrations of Ca(II) followed by signal gene expression changes associated with cell growth, differentiation and apoptosis (Valko et al 2005). Nickel is also referred as an oxidative stress inducer by increasing levels of free radicals in cells (Bal andKasprzak 2002, Chen et al 2003) causing depletion of glutathione (Rodriguez et al 1996), inducing lipid peroxidation (Chen et al 2002) and leading to DNA damage through the generation of reactive oxygen species (ROS; Lynn et al 1997).…”

Section: Background Aim and Scopementioning

confidence: 99%

The influence of natural stressors on the toxicity of nickel to Daphnia magna

Ferreira

Serra

Soares

et al. 2010

Environ Sci Pollut Res

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Global warming has become a source of awareness regarding the potential deleterious effects of extreme abiotic factors (e.g., temperature, dissolved oxygen (DO) levels) and also their influence on chemicals toxicity. In this work, we studied the combined effects of nickel and temperature (low and high levels) and nickel and low levels of DO to Daphnia magna, and concentration addition and independent action concepts as well as their deviations for synergism/antagonism, dose ratio and dose level dependency, were applied to survival and feeding rate data. Nickel single exposure showed an LC(50) value for 48 h of 7.36 mg l(-1) and an EC(50) value for feeding impairment at 2.41 mg l(-1). In the acute exposures to high and low temperatures, 50% of mortality was observed, respectively, at 30.7 degrees C and 4.2 degrees C whereas 50% reduction on the feeding activity was recorded at 22.6 degrees C and 16.0 degrees C. Relatively to low DO levels, a LC(50) value for 48 h of 0.5 mg l(-1) was obtained; feeding activity EC(50) value was 2 mg l(-1). On acute combined experiments, antagonism was observed for the combination of nickel and extreme temperatures, whereas a synergistic behaviour was observed in the combined exposure of nickel and low DO levels. At sublethal levels, nickel showed to be the main inducer of toxicity at high and low temperatures but not at low levels of dissolved oxygen. Toxicokinetics and toxicodynamics modelling studies should be made in the future to understand the toxicological pathways involved on complex combinations of stressors and to validate any conclusions.

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“…GPX in metal exposed mussels showed a similar to SFG biphasic pattern of response, with increased GPX activities at the highest Ni body burden and moderately decreased activities at lower Ni and Cr body burdens. The increased GPX activities indicate enzyme induction possibly as a protection mechanism against ROS that can be produced by Ni [16,17]. Generally, enzymes of the antioxidant defence system are induced by contaminant-mediated production of ROS as a protection mechanism against oxidative stress or inhibited when deficiency of the system occurs [14].…”

Section: Discussionmentioning

confidence: 99%

“…Toxicity and carcinogenicity of Ni and Cr is known to occur due to production of ROS [16]. Ni and Cr undergo redox cycling resulting in production of ROS by reactions with hydrogen peroxide and organic hydroperoxides [16,17] and previous literature data on vertebrate species demonstrate that both metals affect GPX [18,19]. ACHE is an enzyme involved in nerve impulse transmission and its inhibition is widely used as a biomarker of neurotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Biochemical biomarkers and overall health status of musselsMytilus galloprovincialisexposed to nickel and chromium

Tsangaris

Papathanassiou

Nicolaidou

2008

Chemistry and Ecology

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This study examined the effects of nickel and chromium exposure on two biochemical biomarkers, glutathione peroxidase (GPX) and acetylcholinesterase (ACHE), in parallel with an indicator of overall health, Scope for Growth (SFG), in the mussel Mytilus galloprovincialis to evaluate their ecological relevance and to assess their potential use as biomarkers of Ni and Cr pollution. SFG integrates major physiological responses into an index that represents the energy status of the animals and is considered an ecologically relevant biomarker. Following exposure to a range of Ni and Cr concentrations effects of Ni and Cr were evident on GPX and SFG but not on ACHE. Accumulation in the mussels' tissues increased according to exposure concentrations. Adverse effects on the energy status and induction of GPX were found at the higher exposure concentrations while possible hormetic effects on the energy status and moderate GPX suppression were associated with lower exposure concentrations. Nevertheless GPX was negatively correlated with SFG suggesting that GPX responses reflect the overall health of the organisms and thus show potential as an early warning signal of population level effects of Ni and Cr. On the other hand, our results indicate that ACHE is not a suitable biomarker for Ni and Cr pollution.

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Reactive oxygen species are involved in nickel inhibition of DNA repair

Cited by 68 publications

References 53 publications

Metals and apoptosis: Recent developments

Metals and apoptosis: Recent developments

The influence of natural stressors on the toxicity of nickel to Daphnia magna

Biochemical biomarkers and overall health status of musselsMytilus galloprovincialisexposed to nickel and chromium

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