Reactive oxygen species impair the excitation-contraction coupling of papillary muscles after acute exposure to a high copper concentration

Filetti, Filipe Martinuzo; Vassallo, Dalton Valentim; Fioresi, Mirian

doi:10.1016/j.tiv.2018.05.007

Cited by 20 publications

(10 citation statements)

References 33 publications

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“…The available human studies concern the entire kidney or the renal cortex, and do not specifically take the medullary region into consideration (Table 4). Most articles in the literature refer to animal studies [16, 20, 40].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Copper Concentration Between Rejected Renal Grafts and Cancerous Kidneys

Wilk

Wiszniewska

Rzuchowska

et al. 2019

Biol Trace Elem Res

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In the body, disorders in the composition and concentration of trace elements, including copper, can lead to the development of various alterations that may result in incorrect functioning of the kidneys. Data on the concentrations of copper in human kidneys are discussed; however, little is known about the concentration of trace elements within rejected renal grafts and kidneys with tumor lesions. The aim of our study was to compare the copper concentration between cancerous kidneys and rejected renal grafts with the division on renal cortex and renal medulla. Material consisted of kidneys from patients hospitalized at the Department of Urology and General Surgery and Transplantation of the Independent Public Clinical Hospital No. 2 at the Pomeranian Medical University in Szczecin, north-western Poland. The study material consisted of kidneys with tumor lesions ( n = 33), and renal grafts ( n = 10), obtained from patients belongs to the north-western areas of Poland. The examination was performed using ICP-AES method. Regarding the pathological kidneys, excluding grafts, the concentration of Cu in the renal cortex was 52% higher than in medullary region and the difference between the compared concentrations was statistically confirmed ( p < 0.05). Taking into account renal grafts, the concentration of Cu in the medulla was slightly lower than in the cortex (less than 3%). In summary, copper in rejected and cancerous kidneys tends to accumulate in higher amount in the renal cortex than medulla, what can be explained by the fact that renal corpuscles, where the first phase of filtration is performed, are located only in the cortical region of the kidney. Furthermore, renal grafts accumulate significantly less copper than kidneys with neoplastic changes, what could have been caused by immunosuppressive medicines used by the graft recipients. The lower copper concentration in renal grafts could be a consequence of the altered immune system, including inflammatory process or/and non-immune mechanisms. Additionally, cancerous and non-cancerous kidneys exhibit different perfusion rate in renal glomeruli, what can finally lead to disparity in chemical elements concentration, including copper.

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Section: Discussionmentioning

confidence: 99%

Comparison of Copper Concentration Between Rejected Renal Grafts and Cancerous Kidneys

Wilk

Wiszniewska

Rzuchowska

et al. 2019

Biol Trace Elem Res

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“…Copper deficiency suppresses hemoglobin synthesis, which results in anemia, which in turn, increases the cardiac output and eventually results in hypertension [89]. However, some studies highlighted that high copper concentration might suppress the activities of myosin-ATPases and thus results in Ca 2+ overload, which eventually elevates blood pressure [90].…”

Section: Bp Regulating Mechanismmentioning

confidence: 99%

Impact of Micronutrients on Hypertension: Evidence from Clinical Trials with a Special Focus on Meta-Analysis

et al. 2021

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Hypertension (HT) is one of the pivotal risk factors for various detrimental diseases like cardiovascular diseases (CVDs), cerebrovascular disease, and renal dysfunction. Currently, many researchers are paying immense attention to various diet formula (dietary approach) with a special focus on micro and macronutrients along with modified lifestyle and standard anti-hypertensive drugs. Micronutrients (minerals/vitamins) play a central role in the regulation of blood pressure (BP) as they aid the function of macronutrients and also improve the anti-hypertensive functions of some anti-hypertensive agents. Even though several studies have demonstrated the beneficial effects of micronutrients on controlling BP, still some ambiguity exists among the nutritionists/doctors, which combination or individual mineral (dietary approach) contributes to better BP regulation. Therefore, this critical review article was attempted to delineate the underlying role of micronutrients (minerals and vitamins) for the management and prevention or delaying of HT and their related complications with strong affirmation from clinical trials as well as its mechanism of controlling BP. Moreover, the major source and recommended daily allowance (RDA) of various micronutrients are included in this review for guiding common readers (especially HT subjects) and dieticians to choose/recommend a better micronutrient and their combinations (other nutrients and standard anti-hypertensive drugs) for lowering the risk of HT and its related co-morbid conditions like CVDs.

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“…The resultant increase in superoxide may lead to the impairment and dysfunction of endothelial structure, and consequently result in the development of EBP [30]. Furthermore, high copper concentrations can reduce myosin-ATPase activity, resulting in calcium overload [31]. Increased Ca 2+ in smooth muscular layer of vessels may cause an increase in the arterial wall tension nally resulting in EBP [32].…”

Section: Discussionmentioning

confidence: 99%

The association between serum copper concentrations and elevated blood pressure in US youths: National Health and Nutrition Examination Survey 2011-2016

Li¹,

Liu²,

Liao³

et al. 2020

Preprint

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Background Copper is an essential trace metal with potential interest for cardiovascular effects. Few studies have explored the association between copper and blood pressure in children and adolescents (hereafter referred to as youths). Method: We conducted a cross-sectional analysis of 1242 youths aged 8–17 years who participated in the 2011 to 2016 National Health and Nutrition Examination Survey. Using 2017 American Academy of Pediatrics guidelines, Elevated Blood Pressure (EBP) was defined as a mean systolic and/or diastolic blood pressure (BP) ≥ 90th percentile for sex, age, and height for children aged 1–12 years and systolic BP ≥ 120 mmHg or diastolic BP ≥ 80 mmHg for adolescent age 13–17 years. Mean serum copper was 114.17 µg/dL. Results After multiple adjustments, dose-response analyses revealed that EBP was associated with progressively higher serum copper concentrations in a nonlinear trend. In comparison with the lowest quartile of serum copper concentrations, the adjusted odds of EBP for the highest quartile was 5.26 (95% confidence interval [CI], 2.76–10.03). Conclusion Our results suggested that high serum copper concentrations were significantly associated with EBP in US youths.

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Reactive oxygen species impair the excitation-contraction coupling of papillary muscles after acute exposure to a high copper concentration

Cited by 20 publications

References 33 publications

Comparison of Copper Concentration Between Rejected Renal Grafts and Cancerous Kidneys

Comparison of Copper Concentration Between Rejected Renal Grafts and Cancerous Kidneys

Impact of Micronutrients on Hypertension: Evidence from Clinical Trials with a Special Focus on Meta-Analysis

The association between serum copper concentrations and elevated blood pressure in US youths: National Health and Nutrition Examination Survey 2011-2016

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