Reactive Oxygen Species in Modulating Intestinal Stem Cell Dynamics and Function

Nath, Arijit; Chakrabarti, Pitam; Sen, Sushmita; Barui, Ananya

doi:10.1007/s12015-022-10377-1

Cited by 17 publications

(5 citation statements)

References 189 publications

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“…Contrary to our results, it is known that oxidative stress provokes Lgr5 expression, and subsequently promotes the expansion of ISCs [44][45][46]. However, most of the papers point out that ROS-mediated LGR5 transcription and ISCs expansion are connected to colorectal cancer initiation, not physiological turnover [44,45,47]. In fact, robust ROS production in intestinal crypts causes apoptosis and tissue dysfunction; thus, maintaining an adequate level of ROS is critical for cell proliferation and tissue renewal [46,48,49].…”

Section: Discussioncontrasting

confidence: 99%

Implication of Echinochrome A in the Plasticity and Damage of Intestinal Epithelium

Ahn

Shin

et al. 2022

Marine Drugs

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The diverse therapeutic feasibility of the sea urchin-derived naphthoquinone pigment, Echinochrome A (Ech A), has been studied. Simple and noninvasive administration routes should be explored, to obtain the feasibility. Although the therapeutic potential has been proven through several preclinical studies, the biosafety of orally administered Ech A and its direct influence on intestinal cells have not been evaluated. To estimate the bioavailability of Ech A as an oral administration drug, small intestinal and colonic epithelial organoids were developed from mice and humans. The morphology and cellular composition of intestinal organoids were evaluated after Ech A treatment. Ech A treatment significantly increased the expression of LGR5 (~2.38-fold change, p = 0.009) and MUC2 (~1.85-fold change, p = 0.08). Notably, in the presence of oxidative stress, Ech A attenuated oxidative stress up to 1.8-fold (p = 0.04), with a restored gene expression of LGR5 (~4.11-fold change, p = 0.0004), as well as an increased expression of Ly6a (~3.51-fold change, p = 0.005) and CLU (~2.5-fold change, p = 0.01), markers of revival stem cells. In conclusion, Ech A is harmless to intestinal tissues; rather, it promotes the maintenance and regeneration of the intestinal epithelium, suggesting possible beneficial effects on the intestine when used as an oral medication.

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Section: Discussioncontrasting

confidence: 99%

Implication of Echinochrome A in the Plasticity and Damage of Intestinal Epithelium

Ahn

Shin

et al. 2022

Marine Drugs

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“… 154 FoxOs are the primary modulators of reactive oxygen species (ROS) homeostasis. 155 It has been suggested that LSCs' self-renewal may be influenced by increased ROS levels. 156 Therefore, targeting FoxO by affecting the upstream PI3K-AKT pathway could be a therapeutic mechanism to decrease the LSC burden.…”

Section: Signaling Pathways Governing Lsc Maintenancementioning

confidence: 99%

Signaling pathways governing the behaviors of leukemia stem cells

Azizidoost¹,

Nasrolahi²,

Sheykhi-Sabzehpoush³

et al. 2024

Genes & Diseases

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“…These changes include CpG island methylation, histone acetylation on lysine tails, and deacetylation through SIRTs, all of which contribute to ISC fate. 81 , 82 It has been conceived that at low ROS concentration, ISC remain inactive and undifferentiated, preserving their stem-like properties. Higher ROS levels promote ISC proliferation and differentiation, while an excessive increase in ROS ultimately triggers apoptosis.…”

Section: Interplay Between Host and Microbiota In Isc Homeostasismentioning

confidence: 99%

Host-microbiota interaction in intestinal stem cell homeostasis

Wu,

Mu,

et al. 2024

Gut Microbes

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Intestinal stem cells (ISCs) play a pivotal role in gut physiology by governing intestinal epithelium renewal through the precise regulation of proliferation and differentiation. The gut microbiota interacts closely with the epithelium through myriad of actions, including immune and metabolic interactions, which translate into tight connections between microbial activity and ISC function. Given the diverse functions of the gut microbiota in affecting the metabolism of macronutrients and micronutrients, dietary nutrients exert pronounced effects on host-microbiota interactions and, consequently, the ISC fate. Therefore, understanding the intricate host-microbiota interaction in regulating ISC homeostasis is imperative for improving gut health. Here, we review recent advances in understanding host-microbiota immune and metabolic interactions that shape ISC function, such as the role of pattern-recognition receptors and microbial metabolites, including lactate and indole metabolites. Additionally, the diverse regulatory effects of the microbiota on dietary nutrients, including proteins, carbohydrates, vitamins, and minerals (e.g. iron and zinc), are thoroughly explored in relation to their impact on ISCs. Thus, we highlight the multifaceted mechanisms governing host–microbiota interactions in ISC homeostasis. Insights gained from this review provide strategies for the development of dietary or microbiota-based interventions to foster gut health.

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Reactive Oxygen Species in Modulating Intestinal Stem Cell Dynamics and Function

Cited by 17 publications

References 189 publications

Implication of Echinochrome A in the Plasticity and Damage of Intestinal Epithelium

Implication of Echinochrome A in the Plasticity and Damage of Intestinal Epithelium

Signaling pathways governing the behaviors of leukemia stem cells

Host-microbiota interaction in intestinal stem cell homeostasis

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