Reactive oxygen species nanoamplifiers with multi-enzymatic activities for enhanced tumor therapy

Zhao, Shasha; Lai, Kexin; Ye, X; Mou, Juan; Yang, Shiping; Wu, Huixia

doi:10.1039/d3nr00107e

Cited by 4 publications

(2 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Zhao et al developed a novel therapeutic system for cancer therapy using polyethylene glycosylated cerium-doped hollow mesoporous silica NPs to encapsulate SSA, thereby enhancing the dispersion stability of the NDDS in aqueous solutions. These NPs amplified ROS production via the multi-enzymatic activity of cerium, inducing cancer cell death and enhancing therapeutic effectiveness, underscoring the substantial antitumor potential of saponins when integrated into nanocomplexes, coupled with reduced toxicity (S. Zhao, Lai, et al, 2023).…”

Section: Other Saponin Compoundsmentioning

confidence: 99%

The development of nanocarriers for natural products

Huang,

Luo,

Tong

et al. 2024

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

Natural bioactive compounds from plants exhibit substantial pharmacological potency and therapeutic value. However, the development of most plant bioactive compounds is hindered by low solubility and instability. Conventional pharmaceutical forms, such as tablets and capsules, only partially overcome these limitations, restricting their efficacy. With the recent development of nanotechnology, nanocarriers can enhance the bioavailability, stability, and precise intracellular transport of plant bioactive compounds. Researchers are increasingly integrating nanocarrier‐based drug delivery systems (NDDS) into the development of natural plant compounds with significant success. Moreover, natural products benefit from nanotechnological enhancement and contribute to the innovation and optimization of nanocarriers via self‐assembly, grafting modifications, and biomimetic designs. This review aims to elucidate the collaborative and reciprocal advancement achieved by integrating nanocarriers with botanical products, such as bioactive compounds, polysaccharides, proteins, and extracellular vesicles. This review underscores the salient challenges in nanomedicine, encompassing long‐term safety evaluations of nanomedicine formulations, precise targeting mechanisms, biodistribution complexities, and hurdles in clinical translation. Further, this study provides new perspectives to leverage nanotechnology in promoting the development and optimization of natural plant products for nanomedical applications and guiding the progression of NDDS toward enhanced efficiency, precision, and safety.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

show abstract

Section: Other Saponin Compoundsmentioning

confidence: 99%

The development of nanocarriers for natural products

Huang,

Luo,

Tong

et al. 2024

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

show abstract

“…11 It has been discovered that the template concentration affects the colloidal state of MSPs and also the thickness of the external silica layer of the particles. 12 MSPs have been fabricated with the templating method using cationic (Cetyltrimethylammonium bromide: CTAB) or neutral surfactants (n-dodecylamine) as templates to yield high-quality mesoporous particles with tailored characteristics. This method inevitably requires many precursors with various compositions and characteristics, making it expensive, low-yield, and time-consuming.…”

Section: Introductionmentioning

confidence: 99%

Large scale synthesis of mesoporous and nonporous silica submicron particles via polymer‐derived ceramic method

Paryab,

Saghatchi,

Behsam

et al. 2023

Int J Applied Ceramic Tech

View full text Add to dashboard Cite

Mesoporous silica particles (MSPs) are highly important in applications like H2 storage, catalysis/biocatalysis, adsorption, separation, and particularly in biomedical applications. The typical methods for producing MSPs are fast self‐assembly, soft and hard templating, and the modified Stöber method. These approaches have drawbacks like high cost, being time‐consuming, and low scale. Herein, as a novel strategy, a polymer‐derived ceramic method for large‐scale production of mesoporous and dense silica submicron particles with high yield and low cost is presented. This method requires commercial silicone resin, polydimethylsiloxane, as the main precursor of silica. However, this technique did not show high control over the size and surface area compared with the typical methods of MSPs synthesis but is definitely a significant step toward the large‐scale synthesis of MSPs.

show abstract

Intelligent nanozymes: Biomimetic design, mechanisms and biomedical applications

Wang,

Hou,

Tang

et al. 2024

Fundamental Research

View full text Add to dashboard Cite

Reactive oxygen species nanoamplifiers with multi-enzymatic activities for enhanced tumor therapy

Abstract: The ingenious combination of nano-enzymes with multi-enzyme activities and therapeutic drugs that can promote reactive oxygen species (ROS) production in cancer cells will enhance the therapeutic efficacy of nanomedicines on...

Cited by 4 publications

References 40 publications

The development of nanocarriers for natural products

The development of nanocarriers for natural products

Large scale synthesis of mesoporous and nonporous silica submicron particles via polymer‐derived ceramic method

Intelligent nanozymes: Biomimetic design, mechanisms and biomedical applications

Contact Info

Product

Resources

About