Reactive oxygen species-responsive polymeric nanoparticles for alleviating sepsis-induced acute liver injury in mice

Propolis Extract Attenuates Sepsis-Induced Hepatotoxicity and Neurotoxicity in Male Rats

“…Furthermore, severe pathological damages such as sinusoidal dilatation, congestion of central vein, lipid accumulation and lymphocyte infiltration were evident in the liver after sepsis induction in the present work. The present results concerning sepsis oxidative stress and inflammation were in agreement with (Chen et al, 2017 andSurewaard et al, 2018). In sepsis, the overproduction of oxidative stress and inflammatory cytokines were two clinical hallmarks indicating host immune defense against infection (Schuler et al, 2018).…”

Oxidation‐Responsive Materials: Biological Rationale, State of the Art, Multiple Responsiveness, and Open Issues

“…It is therefore of little surprise to realize that synthetic ROS scavengers, sometimes also similar in composition (e.g., sulfur(II)‐based systems) are also inherently endowed with anti‐inflammatory properties. The recent literature provides a certain number of cases where this feature has been exploited; for example, PPS‐PEG diblock copolymers used to alleviate the symptoms of sepsis, or for the cytoprotection of stem cell in injectable formulations, PPS microparticles for those of ischemia, poly(ester sulfide) nanoparticles and copolymers of 2‐(methylthio)ethyl methacrylate for those of traumatic brain injury, boronated cyclodextrins for those of peritonitis, and PEGylated bilirubin nanoparticles for colon inflammation . It is worth mentioning that ROS scavenging are not a prerogative of oxidation‐responsive polymers: a number of organic materials can remove ROS/radicals without significantly changing their properties, but produce anti‐inflammatory effects, for example, carbon particles and above all 2,2,6,6‐tetramethylpiperidine‐N‐oxyl (TEMPO)‐containing systems (see also a recent review on the latter materials).…”

Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Novel Cell-Free Therapy for Sepsis

“…During sepsis, liver injury occurs frequently and contributes to the pathogenesis of multiple organ dysfunction, and has been considered as an early indicator of poor outcome in septic patients (74,75). Studies in a range of liver disease models demonstrated that MSC-EVs could suppress inflammatory response, reduce hepatocyte apoptosis, and enhance liver regeneration.…”