2012
DOI: 10.1016/j.cellsig.2012.01.008
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Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

Abstract: Reactive oxygen species (ROS) are generated during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. Oxidative stress refers to the imbalance due to excess ROS or oxidants over the capability of the cell to mount an effective antioxidant response. Oxidative stress results in macromolecular damage and is implicated in various disease states such as atherosclerosis, diabetes, cancer, neurodegeneration, and aging. Paradoxically, accumulating evid… Show more

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Cited by 3,713 publications
(2,701 citation statements)
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References 149 publications
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“…Our results are in line with previous findings on the relationship between HIF‐1α and mitochondrial dysfunction 40, 41. It is known that ROS are mainly generated from complex III of the electron transport chain in the mitochondria, which are increased under hypoxic conditions 42. Activated HIF‐1α expression could prevent cancer cells from ROS‐induced apoptosis,43 while knockdown of HIF‐1α could induce cell apoptosis 17.…”
Section: Discussionsupporting
confidence: 91%
“…Our results are in line with previous findings on the relationship between HIF‐1α and mitochondrial dysfunction 40, 41. It is known that ROS are mainly generated from complex III of the electron transport chain in the mitochondria, which are increased under hypoxic conditions 42. Activated HIF‐1α expression could prevent cancer cells from ROS‐induced apoptosis,43 while knockdown of HIF‐1α could induce cell apoptosis 17.…”
Section: Discussionsupporting
confidence: 91%
“…However, oxidative stress caused by over production of ROS induces cell damage of macromolecules such as DNA, proteins, and lipids (Reuter, Gupta, Chaturvedi, & Aggarwal, 2010). Accumulation of such cell damage leads to chronic diseases including cancer, cardiovascular diseases, neurodegenerative diseases, and others (Ray, Huang, & Tsuji, 2012). Various literatures have emphasized importance of antioxidants on attenuating oxidative stress and its associated chronic diseases (Baynes, 1991; Osawa & Kato, 2005).…”
Section: Introductionmentioning
confidence: 99%
“…ROS are signaling molecules that regulate cell proliferation, differentiation, and survival. [1][2][3] Accumulation of ROS (i.e., oxidative stress) on exposure to xenobiotic agents or environmental toxins can cause cellular damage and death via apoptotic or nonapoptotic pathways. [4][5][6] Oxidative stress-induced cellular damage and death have been implicated in aging, ischemia-reperfusion injury, inflammation, and the pathogenesis of diseases (e.g., neurodegeneration and cancer).…”
mentioning
confidence: 99%