Reactive oxygen species (ROS) in macrophage activation and function in diabetes

Rendra, Erika; Riabov, Vladimir; Mossel, Dieuwertje M; Sevastyanova, Tatyana; Harmsen, Martin C.; Kzhyshkowska, Julia

doi:10.1016/j.imbio.2018.11.010

Cited by 438 publications

(277 citation statements)

References 141 publications

Supporting

Mentioning

261

Contrasting

Unclassified

Order By: Relevance

“…Expression of IL-6, IFN-γ, and MCP-1 were significantly elevated in ALI tissues and led to development of inflammation [29]. In addition, excessive free radicals can activate hepatic macrophages to intense proinflammatory reaction via producing proinflammatory cytokines [30]. In our study, treatment of tBHQ significantly reduced levels of proinflammatory cytokines in CCL4 treated mice, which is crucial in mitigating liver injury.…”

Section: Discussionsupporting

confidence: 54%

Tert-butylhydroquinone mitigates Carbon Tetrachloride induced Hepatic Injury in mice

Zhang

et al. 2020

Int. J. Med. Sci.

View full text Add to dashboard Cite

Tert-butylhydroquinone (tBHQ) is an antioxidant compound that exhibits cytoprotective effect in many tissues under pathological condition. However, its role in carbon tetrachloride (CCL4) induced liver injury is still unclear. Here we established a carbon tetrachloride induced hepatic injury model in mice to determine whether tBHQ can mitigate CCL4 induced liver damage. In our study, we found tBHQ exhibited protective effects in CCL4 treated mice model. TBHQ markedly improved hepatic function and decreased hepatic histopathological damage in vivo. In addition, tBHQ reduced levels of pro-inflammatory cytokines in mice model. Moreover, tBHQ mitigated apoptosis of hepatocytes, oxidative stress and lipid peroxidation in vivo and in vitro. We also found the possible mechanism of protective effects of tBHQ was associated with activation of Nrf2/ heme oxygenase-1 (HO-1) pathway. In conclusion, our study revealed tBHQ can be a potential therapeutic drug in treatment of acute hepatic injury.

show abstract

Section: Discussionsupporting

confidence: 54%

Tert-butylhydroquinone mitigates Carbon Tetrachloride induced Hepatic Injury in mice

Zhang

et al. 2020

Int. J. Med. Sci.

View full text Add to dashboard Cite

show abstract

“…As mentioned above, prolonged as well as elevated levels of glucose blood, high free fatty acids, and chronic inflammatory environment, all increase the levels of ROS, activating the mechanism of oxidative stress (81). Furthermore, the islet β cells are especially sensitive to ROS because of their low inherent level of antioxidant enzymes.…”

Section: Impaired Insulin Secretionmentioning

confidence: 99%

Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments

et al. 2020

View full text Add to dashboard Cite

Sarcopenic obesity and diabetes are two increasing health problems worldwide, which both share many common risk factors, such as aging, and general obesity. The pathogenesis of sarcopenic obesity includes aging, physical inactivity, malnutrition, low-grade inflammation, insulin resistance, and hormonal changes. Nevertheless, there are two major reasons to cause diabetes: impaired insulin secretion and impaired insulin action. Furthermore, the individual diagnosis of obesity and sarcopenia should be combined to adequately define sarcopenic obesity. Also, the diagnosis of diabetes includes fasting plasma glucose test (FPG), 2-h oral glucose tolerance test (OGTT), glycated hemoglobin (A1C), and random plasma glucose coupled with symptoms. Healthy diet and physical activity are beneficial to both sarcopenic obesity and diabetes, but there are only recommended drugs for diabetes. This review consolidates and discusses the latest research in pathogenesis, diagnosis, and treatments of diabetes and sarcopenic obesity.

show abstract

“…Thrombospondin‐1 (TSP1), which is a major regulator of TGFβ1 activity, 48,49 is secreted by adipocytes and has elevated expression under conditions of obesity 50‐52 . TGFβ1 can also be activated within the ECM by localized concentrations of reactive oxygen species, which may be elevated in obese adipose tissue by macrophages and adipocytes 53,54 . While we have shown that macrophages enhance secretion of decorin, macrophages can also express latent TGFβ1 55 .…”

Section: Discussionmentioning

confidence: 79%

Obesity reduces mammary epithelial cell TGFβ1 activity through macrophage‐mediated extracellular matrix remodeling

et al. 2020

View full text Add to dashboard Cite

Obesity is a risk factor for breast cancer in postmenopausal and high‐risk premenopausal women. Changes within the obese breast microenvironment may increase breast cancer risk. Transforming growth factor beta‐1 (TGFβ1) is a major regulator of mammary epithelial stem/progenitor cells, and its activity is dysregulated under conditions of obesity. Using a high‐fat diet model of obesity in mice and breast tissue from women, we observed that TGFβ1 activity is reduced in breast epithelial cells in obesity. Breast ducts and lobules demonstrated increased decorin in the extracellular matrix (ECM) surrounding epithelial cells, and we observed that decorin and latent TGFβ1 complexed together. Under conditions of obesity, macrophages expressed higher levels of decorin and were significantly increased in number surrounding breast epithelial cells. To investigate the relationship between macrophages and decorin expression, we treated obese mice with either IgG control or anti‐F4/80 antibodies to deplete macrophages. Mice treated with anti‐F4/80 antibodies demonstrated reduced decorin surrounding mammary ducts and enhanced TGFβ1 activity within mammary epithelial cells. Given the role of TGFβ1 as a tumor suppressor, reduced epithelial TGFβ1 activity and enhanced TGFβ1 within the ECM of obese mammary tissue may enhance breast cancer risk.

show abstract

Reactive oxygen species (ROS) in macrophage activation and function in diabetes

Cited by 438 publications

References 141 publications

Tert-butylhydroquinone mitigates Carbon Tetrachloride induced Hepatic Injury in mice

Tert-butylhydroquinone mitigates Carbon Tetrachloride induced Hepatic Injury in mice

Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments

Obesity reduces mammary epithelial cell TGFβ1 activity through macrophage‐mediated extracellular matrix remodeling

Contact Info

Product

Resources

About