Reactive oxygen species scavenging activity during periodontal mucoperiosteal healing: An experimental study in dogs

Sakallıoğlu, Umur; Алиев, Э. С.; Eren, Zafer; Akşimşek, Gülhan; Keskiner, İlker; Yavuz, Ümit

doi:10.1016/j.archoralbio.2005.03.012

Cited by 23 publications

(21 citation statements)

References 33 publications

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“…The purpose of this study was to investigate EGF administration on antioxidant status in the oral wound healing on days 1, 3, and 5 after incisional surgery. Excessive release of ROS in wounded tissue is a deleterious and destructive phenomenon for the healing process due to inflammation and ischaemia (Sakallıoglu et al, 2005). Neutrophils can contribute to tissue destruction by the production of reactive oxygen metabolites via MPO activity, granule enzymes, and cytokines that further amplify the inflammatory response (Salvemini et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Effect of exogenous epidermal growth factor (EGF) on nonenzymatic antioxidant capacities and MPO activity of wound tissue

et al. 2009

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Growth factors and cytokines are key regulators of the wound-healing process. Epidermal growth factor (EGF) plays a vital role during the process of wound healing. There are limited numbers of studies related to EGF implantation effects on oxidative stress in oral wound healing. The objective of this study was to investigate the effect of EGF on myeloperoxidase (MPO) activity and nonenzymatic antioxidant levels of oral wound tissue on different days. In this study, New Zealand male albino rabbits were used. After submucosal incisions, the rabbits were divided into two equal groups: untreated wounds, and EGF-implanted wounds. The levels of glutathione (GSH), ascorbic acid (AA), and MPO activity were measured spectrophotometrically. As a result, MPO activity of oral wound tissue strips was increased by exogenous EGF treatment compared with controls. In addition, GSH and AA levels of oral wound tissue strips were not changed during oral wound-healing phases for both controls and experimental groups.

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Section: Discussionmentioning

confidence: 99%

Effect of exogenous epidermal growth factor (EGF) on nonenzymatic antioxidant capacities and MPO activity of wound tissue

et al. 2009

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“…During the inflammatory process, T lymphocytes, macrophages, and polymorphonuclear neutrophil (PMNs) infiltrate the affected sites with PMNs representing the majority of the infiltrate. The latter produce proteases and reactive oxygen species (ROS) which can be useful for management of microbial invasion but in excess can also cause periodontal tissue damage. Additionally, other cells such as fibroblasts, vascular endothelial cells, and osteoclasts also produce ROS .…”

Section: Introductionmentioning

confidence: 99%

Resveratrol attenuates oxidative stress during experimental periodontitis in rats exposed to cigarette smoke inhalation

Corrêa¹,

Absy²,

Tenenbaum

et al. 2018

J of Periodontal Research

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Objectives This study aimed at investigating the effect of the systemic administration of resveratrol (RESV) on oxidative stress during experimental periodontitis in rats subjected to cigarette smoke inhalation. Material and Methods Experimental periodontitis (EP) was induced in 26 male Wistar rats by the insertion of a ligature around one of the first mandibular and maxillary molars. The animals were assigned randomly to the following groups: cigarette smoke inhalation (CSI; 3 times/d, 8 minutes/d) + resveratrol (10 mg/Kg), that is, SMK + RESV (n = 13) and cigarette smoke inhalation + placebo, that is, SMK + PLAC (n = 13). The substances were administered daily for 30 days (19 days prior and 11 days following EP induction), and then, the animals were euthanized. The maxillary specimens were processed for morphometric analysis of bone loss, and the tissue surrounding the first maxillary molars was collected for mRNA quantification of Sirtuin 1 (SIRT1) by real‐time PCR. The gingival tissues surrounding the mandibular first molars were collected for quantification of superoxide dismutase 1 (SOD1) and nicotinamide adenine dinucleotide phosphatase oxidase (NADPH) using an ELISA assay. Results Reduced bone loss was demonstrated in animals in the SMK + RESV group as compared to those in the SMK + PLAC (P < 0.05) group on the basis of morphometric analysis. Resveratrol promoted higher levels of SIRT and SOD (P < 0.05) as well as reduced levels of NADPH oxidase (P < 0.05) were found in tissues derived from animals in the SMK + RESV group when compared to those in the SMK + PLAC group. Conclusion Resveratrol is an efficient therapeutic agent that reduces exacerbation of bone loss found in animals with EP that were also exposed to smoke. The results suggest that its effects could be mediated, at least in part, by its antioxidant and anti‐inflammatory properties which attenuate the effects of oxidative stress on EP in the presence of cigarette smoke.

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“…Prolonged ROS production also results in damage to DNA, lipids, and proteins; increases tissue damage and apoptosis; and plays an important role in late diabetic complications 14–16 . Increased ROS and imbalance of oxidants/antioxidants also alter homeostasis in tissues and organs, and antioxidants provide and maintain physiologic balance 17 …”

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confidence: 99%

The Effect of Melatonin on Bone Loss, Diabetic Control, and Apoptosis in Rats With Diabetes With Ligature‐Induced Periodontitis

Yüce

Karataş

Turkal

et al. 2016

Journal of Periodontology

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Reactive oxygen species scavenging activity during periodontal mucoperiosteal healing: An experimental study in dogs

Cited by 23 publications

References 33 publications

Effect of exogenous epidermal growth factor (EGF) on nonenzymatic antioxidant capacities and MPO activity of wound tissue

Effect of exogenous epidermal growth factor (EGF) on nonenzymatic antioxidant capacities and MPO activity of wound tissue

Resveratrol attenuates oxidative stress during experimental periodontitis in rats exposed to cigarette smoke inhalation

The Effect of Melatonin on Bone Loss, Diabetic Control, and Apoptosis in Rats With Diabetes With Ligature‐Induced Periodontitis

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