Reactive Oxygen Species Scavenging Properties of ZrO
            <sub>2</sub>
            –CeO
            <sub>2</sub>
            Solid Solution Nanoparticles

Tsai, Yi-Yang; Oca‐Cossio, Jose; Lin, Sheng-Min; Woan, Karran V.; Yu, Pei-Ching; Sigmund, Wolfgang M.

doi:10.2217/17435889.3.5.637

Cited by 46 publications

(32 citation statements)

References 25 publications

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“…37 High surface areas can also increase surface reactivity leading to catalytic activities that can be both beneficial and detrimental to cells. 15 The surface areas, as determined by BET, closely ranged between 71 and 118 m 2 /g and it appeared that the presence of HMT had no dramatic influence on surface area.…”

Section: Resultsmentioning

confidence: 99%

“…The amount of HMT that remains on the surface of the nanoparticles was determined with differential scanning calorimetry and thermogravimetric analysis (DSC-TGA) using a TA Instruments SDT-Q600 (New Castle, DE), with open alumina pans under 100 mL/min air flow. Particle size analysis was also carried out by measuring the specific surface area (m 2 /g) using the Brunauer, Emmett, and Teller (BET) method with a Quantachrome Nova 4200e surface area analyzer (Boynton Beach, FL).…”

Section: Methodsmentioning

confidence: 99%

“…However in the nanoscale regime, CeO 2 NPs (CNPs) retain their fluorite structure with oxygen deficiencies, yielding CeO 2-x , with vacancies as the most likely sites for reduction-oxidation (redox) reactions. 2 This unique property of CNPs make it useful for industrial applications including the removal of carbon monoxide (CO), hydrocarbons and nitric oxide species (NO x ) from exhaust gas. 3 This property of CNPs is facilitated by the ability of CNPs to mediate its oxidation state between 3+ and 4+.…”

mentioning

confidence: 99%

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Cellular Interaction and Toxicity Depend on Physicochemical Properties and Surface Modification of Redox-Active Nanomaterials

Dowding¹,

Das²,

Kumar³

et al. 2013

ACS Nano

186

146

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The study of the chemical and biological properties of CeO2 NPs (CNPs) has expanded recently due to its therapeutic potential, and the methods used to synthesize these materials are diverse. Moreover, conflicting reports exists regarding the toxicity of CNP. To help resolve these discrepancies, we must first determine whether CeO2 NPs made by different methods are similar or different in their physiochemical and catalytic properties. In this paper, we have synthesized several forms of CNPs using identical precursors through a wet chemical process but using different oxidizer/reducer H2O2 (CNP1), NH4OH (CNP2) or hexamethylenetetramine (HMT-CNP1). Physiochemical properties of these CeO2 NPs were extensively studied and found to be different depending on the preparation methods. Unlike CNP1 and CNP2, HMT-CNP1 were readily taken into endothelial cells and their aggregation can be visualized using light microscopy. Exposure to HMT-CNP1 also reduced cell viability (MTT) at a 10-fold lower concentration than CNP1 or CNP2. Surprisingly, exposure to HMT-CNP1 led to substantial decreases in the ATP levels. Mechanistic studies revealed that HMT-CNP1 exhibited substantial ATPase (phosphatase) activity. Though CNP2 also exhibits ATPase activity, CNP1 lacked ATPase activity. The difference in catalytic (ATPase) activity of different CeO2 NPs preparation may be due to differences in their morphology and oxygen extraction energy. These results suggest the combination of increased uptake and ATPase activity of HMT-CNP1 may underlie the biomechanism of the toxicity of this preparation of CNPs, and may suggest ATPase activity should be considered when synthesizing CNPs for use in biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Cellular Interaction and Toxicity Depend on Physicochemical Properties and Surface Modification of Redox-Active Nanomaterials

Dowding¹,

Das²,

Kumar³

et al. 2013

ACS Nano

186

146

View full text Add to dashboard Cite

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“…Impurity-doping or supporting effects can adjust the chemical reactivity of nanomaterials through modification of the electronic structure. Tsai et al 635 synthesized a series of Ce x Zr 1−x O 2 nanoparticles at room temperature using the reverse micelle method. The ROSscavenging activity of Ce 0.7 Zr 0.3 O 2 nanoparticles could be enhanced 4-fold as compared to CeO 2 nanoparticles.…”

Section: Key Factors Influencing the Antioxidant Properties Of Nanoceriamentioning

confidence: 99%

Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

et al. 2015

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“…The antioxidant properties of CeO 2 NPs are accomplished through its ability to switch from the 3+ to the 4+ valence state ( Hirst et al 2009 ). It has been shown that the antioxidant efficacy of CeO 2 NPs can be affected by incorporation of zirconium (Zr) in the CeO 2 lattice ( Tsai et al 2008 ). However, whilst research has been devoted since many years to elaborate on neuroprotective and potential anti-neurodegenerative effects of CeO 2 ( Singh et al, 2007 ), adverse effects on the brain should also be considered for this type of nanoparticles as indicated e.g.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of neurological effects of cerium dioxide nanoparticles doped with different amounts of zirconium following inhalation exposure in mouse models of Alzheimer's and vascular disease

Wahle

Sofranko

Dekkers

et al. 2020

Neurochemistry International

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Increasing evidence from toxicological and epidemiological studies indicates that the brain is an important target for ambient (ultrafine) particles. Disturbance of redox-homeostasis and inflammation in the brain are proposed as possible mechanisms that can contribute to neurotoxic and neurodegenerative effects. Whether and how engineered nanoparticles (NPs) may cause neurotoxicity and promote neurodegenerative diseases such as Alzheimer's disease (AD) is largely unstudied. We have assessed the neurological effects of subacute inhalation exposures (4 mg/m 3 for 3 h/day, 5 days/week for 4 weeks) to cerium dioxide (CeO 2 ) NPs doped with different amounts of zirconium (Zr, 0%, 27% and 78%), to address the influence of particle redox-activity in the 5xFAD transgenic mouse model of AD. Four weeks post-exposure, effects on behaviour were evaluated and brain tissues were analysed for amyloid-β plaque formation and reactive microglia (Iba-1 staining). Behaviour was also evaluated in concurrently exposed non-transgenic C57BL/6J littermates, as well as in Western diet-fed apolipoprotein E-deficient (ApoE -/- ) mice as a model of vascular disease. Markers of inflammation and oxidative stress were evaluated in brain cortex. The brains of the NP-exposed 5xFAD mice revealed no accelerated amyloid-β plaque formation. No significant treatment-related behaviour impairments were observed in the healthy C57BL/6J mice. In the 5xFAD and ApoE -/- models, the NP inhalation exposures did not affect the alternation score in the X-maze indicating absence of spatial working memory deficits. However, following inhalation exposure to the 78% Zr-doped CeO 2 NPs changes in forced motor performance (string suspension) and exploratory motor activity (X-maze) were observed in ApoE -/- and 5xFAD mice, respectively. Exposure to the 78% doped NPs also caused increased cortical expression of glial fibrillary acidic protein (GFAP) in the C57BL/6J mice. No significant treatment-related changes neuroinflammation and oxidative stress were observed in the 5xFAD and ApoE -/- mice. Our study findings reveal that subacute inhalation exposure to CeO 2 NPs does not accelerate the AD-like phenotype of the 5xFAD model. Further investigation is warranted to unravel whether the redox-activity dependent effects on motor activity as observed in the mouse models of AD and vascular disease result from specific neurotoxic effects of these NPs.

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Reactive Oxygen Species Scavenging Properties of ZrO ₂ –CeO ₂ Solid Solution Nanoparticles

Cited by 46 publications

References 25 publications

Cellular Interaction and Toxicity Depend on Physicochemical Properties and Surface Modification of Redox-Active Nanomaterials

Cellular Interaction and Toxicity Depend on Physicochemical Properties and Surface Modification of Redox-Active Nanomaterials

Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

Evaluation of neurological effects of cerium dioxide nanoparticles doped with different amounts of zirconium following inhalation exposure in mouse models of Alzheimer's and vascular disease

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Reactive Oxygen Species Scavenging Properties of ZrO 2 –CeO 2 Solid Solution Nanoparticles

Cited by 46 publications

References 25 publications

Cellular Interaction and Toxicity Depend on Physicochemical Properties and Surface Modification of Redox-Active Nanomaterials

Cellular Interaction and Toxicity Depend on Physicochemical Properties and Surface Modification of Redox-Active Nanomaterials

Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

Evaluation of neurological effects of cerium dioxide nanoparticles doped with different amounts of zirconium following inhalation exposure in mouse models of Alzheimer's and vascular disease

Contact Info

Product

Resources

About

Reactive Oxygen Species Scavenging Properties of ZrO ₂ –CeO ₂ Solid Solution Nanoparticles