Reactive Oxygenated Species (ROS) in Male Fertility; Source, Interaction Mechanism and Antioxidant Therapy

Fatehi, Daryoush; Moayeri, Ardeshir; Rostamzadeh, Omid; Rostamzadeh, Ayoob; Kebria, Maziar Malekzadeh

doi:10.5958/0974-360x.2018.00150.6

Cited by 16 publications

(6 citation statements)

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“…ROS production, which affects aging biomarkers, plays a major part in the age-related loss in male fertility (Alahmar, 2019;Wang et al, 2022). The findings showed that older animals created more free radicals than younger ones and had decreased antioxidant activity in their spermatozoa (Sabeti et al, 2016;Fatehi et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

The Impact of Aging on the Quality of Sperm in White Rats (Rattus Norvegicus) Wistar Strain

Widiastini,

Karuniadi,

Tangkas

2023

j. info kesehat.

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Due to the reproductive aging process, the testes, epididymis, and other reproductive organs gradually lose all their physiological capabilities. This study aimed to determine the effect of aging on the sperm quality of Wistar rats (Rattus Norvegicus). The research design is quantitative and descriptive. This study used white male rats (Rattus norvegicus) of the Wistar strain aged 19–20 months. The number of samples was 18 individuals, with a purposive sampling technique following the inclusion and exclusion criteria. Mice were put to sleep on the seventh day, then the cauda epididymis and testes were separated, and a media container was used to accommodate them. The spermatozoa produced were then examined for their motility, morphology, and viability. The results showed that the range, mean, and standard deviation of progressive motility of spermatozoa was 5.83%, 217% ± 1.87%, normal morphology was 39.17%, 61.6% ± 9.57%, and spermatozoa viability was 19.50%, 74.6 ± 5.83%. There was a progressive decrease in motility, but morphology was expected, and spermatozoa viability was within normal limits. This study concludes that aging affects spermatozoa motility, but the morphology and viability of spermatozoa are still within normal limits. Future studies should do genetic analysis to determine how hereditary factors affect the quality of sperm in aged white rats and compare the results to those of young rats to identify changes in sperm quality.

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Section: Resultsmentioning

confidence: 99%

The Impact of Aging on the Quality of Sperm in White Rats (Rattus Norvegicus) Wistar Strain

Widiastini,

Karuniadi,

Tangkas

2023

j. info kesehat.

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“…Excess cytoplasm produces endogenous reactive oxygen species (ROS) in teratozoospermia patients with a proportion of aberrant sperm damage over the threshold of 96%, according to several studies [ 35 , 36 ]. ROS is produced in these patients by a malfunction in the spermatogenesis process, which results in a large number of sperm with cytoplasmic residues [ 37 ]. When spermatozoa are exposed to ROS, DNA damage and lipid peroxidation can occur [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

The correlation of Septin4 gene expression with sperm quality, DNA damage, and oxidative stress level in infertile patients

Jannatifar,

Piroozmanesh,

Jalalabadi

et al. 2023

Anat Cell Biol

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Septin4 belong to a family of polymerizing GTP-binding proteins that are required for many cellular functions, such as membrane compartmentalization, vesicular trafficking, mitosis, and cytoskeletal remodeling. Since, Septin4 is expressed specifically in the testis, we aimed to determine the association between Septin4 gene expression with sperm quality, DNA damage, and stress oxidative level in infertile patients. The present study included 60 semen samples that grouped into three groups: normozoospermia (n=20), asthenozoospermia (n=20), astheno-teratozoospermia (n=20). Initially, semen parameters were analyzed by using the World Health Organization protocol. The mRNA expression of Septin4 in sperm was examined using reverse transcription-polymerase chain reaction. Oxidative stress markers, i.e., total antioxidant capacity, superoxide dismutase, catalase, glutathione peroxidase, and malondialdehyde, were determined by ELISA kit. The current study showed a statistically significant highly positive correlation in Septin4 gene expression with sperm motility, normal morphology, viability, capacity, and sperm mitochondrial membrane potential (MMP). However, it showed significant negative correlation with sperm DNA fragmentation. Septin4 had a significant correlation with stress oxidative factor and antioxidant enzyme levels. In conclusion, Septin4 gene expression provides clinical useful information for the diagnosis of male infertility. It might be a marker for discrimination between fertile and infertile patients. The current study showed a statistically significant highly positive correlation in Septin4 gene expression with sperm motility, normal morphology, viability, capacity, and sperm MMP. However, it shows significant negative correlation with sperm DNA fragmentation. Septin4 had a significant correlation with stress oxidative factor and antioxidant enzyme levels.

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“…They increase the production of NADPH via the hexose monophosphate pathway and myeloperoxidase system, leading to ROS overproduction [ 57 ]. Two systems for producing ROS by spermatozoa are the NADPH oxidase system in the plasma membrane of sperm and the NADPH-dependent oxidoreductase in the mitochondria [ 58 , 59 ].…”

Section: Infertility and Oxidative Stressmentioning

confidence: 99%

Arsenic, Oxidative Stress and Reproductive System

Zargari

Rahaman

Kazempour

et al. 2022

JoX

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Infertility is a severe medical problem and is considered a serious global public health issue affecting a large proportion of humanity. Oxidative stress is one of the most crucial factors involved in infertility. Recent studies indicate that the overproduction of reactive oxygen species (ROS) or reactive nitrogen species (RNS) may cause damage to the male and female reproductive systems leading to infertility. Low amounts of ROS and RNS are essential for the normal functioning of the male and female reproductive systems, such as sperm motility, acrosome reaction, interactions with oocytes, ovulation, and the maturation of follicles. Environmental factors such as heavy metals can cause reproductive dysfunction in men and women through the overproduction of ROS and RNS. It is suggested that oxidative stress caused by arsenic is associated with male and female reproductive disorders such as through the alteration in sperm counts and motility, decreased sex hormones, dysfunction of the testis and ovary, as well as damage to the processes of spermatogenesis and oogenesis. This review paper highlights the relationship between arsenic-induced oxidative stress and the prevalence of infertility, with detailed explanations of potential underlying mechanisms.

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Reactive Oxygenated Species (ROS) in Male Fertility; Source, Interaction Mechanism and Antioxidant Therapy

Cited by 16 publications

References 0 publications

The Impact of Aging on the Quality of Sperm in White Rats (Rattus Norvegicus) Wistar Strain

The Impact of Aging on the Quality of Sperm in White Rats (Rattus Norvegicus) Wistar Strain

The correlation of Septin4 gene expression with sperm quality, DNA damage, and oxidative stress level in infertile patients

Arsenic, Oxidative Stress and Reproductive System

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