Reactive Polymer Coatings for Biomimetic Surface Engineering

Lahann, Jörg

doi:10.1080/00986440500511619

Cited by 35 publications

(21 citation statements)

References 102 publications

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“…“Reactive parylene” films can be used to modify interfacial properties and by functionalizing the paracyclophane dimer with a variety of reactive chemical groups [20–22]. Recent research has used complementary reactive parylene films having aldehyde and aminomethyl groups, PPX-CHO and PPX-CH 2 NH 2 respectively, to improve adhesion strength of PDMS on silicon [23].…”

Section: Introductionmentioning

confidence: 99%

The insulation performance of reactive parylene films in implantable electronic devices

et al. 2009

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Parylene-C (poly-chloro-p-xylylene) is an appropriate material for use in an implantable, microfabricated device. It is hydrophobic, conformally deposited, has a low dielectric constant, and superb biocompatibility. Yet for many bioelectrical applications, its poor wet adhesion may be an impassable shortcoming. This research contrasts parylene-C and poly(p-xylylene) functionalized with reactive group X (PPX-X) layers using long-term electrical soak and adhesion tests. The reactive parylene was made of complementary derivatives having aldehyde and aminomethyl side groups (PPX-CHO and PPX-CH2NH2 respectively). These functional groups have previously been shown to covalently react together after heating. Electrical testing was conducted in saline at 37°C on interdigitated electrodes with either parylene-C or reactive parylene as the metal layer interface. Results showed that reactive parylene devices maintained the highest impedance. Heat-treated PPX-X device impedance was 800% greater at 10 kHz and 70% greater at 1Hz relative to heated parylene-C controls after 60 days. Heat treatment proved to be critical for maintaining high impedance of both parylene-C and the reactive parylene. Adhesion measurements showed improved wet metal adhesion for PPX-X, which corresponds well with its excellent high frequency performance.

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Section: Introductionmentioning

confidence: 99%

The insulation performance of reactive parylene films in implantable electronic devices

et al. 2009

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“…Specifically, compound 3 was synthesized and used to prepare ultrahydrophobic coatings of polymer 4 which contained a carbonyl-functionalized derivative with an 8-carbon perfluorinated side chain (Scheme 1). Given the usefulness of non-functionalized, as well as the perfluorinated PPX, for coating applications, [2,13,14,22] widening the scope of CVD polymerization by applying this technique to reactive, yet partially fluorinated paracyclophanes, may significantly advance the field of low-surface energy coatings. Not only do new polymer coatings, such as polymer 4, possess robust chemical properties, but their reactivity also allows for subsequent surface modifications.…”

Section: Introductionmentioning

confidence: 99%

Partially Fluorinated Poly‐p‐xylylenes Synthesized by CVD Polymerization

Elkasabi

Nandivada

Chen

et al. 2009

Chemical Vapor Deposition

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This paper describes partially fluorinated poly-p-xylylenes prepared by CVD polymerization. The synthesis, characterization, and surface modification of two partially fluorinated polymer coatings, namely poly(4,12-dibromo-1,1,9,9-tetrafluoro-pxylylene) (2) and poly(4-heptadecafluorononanoyl-p-xylylene-co-p-xylylene) (4), is described. Polymer 2 is synthesized from 4,12-dibromo-1,1,9,9-tetrafluoro[2.2]paracyclophane (1), which is fluorinated at the aliphatic bridge, while 4-heptadecafluorononanoyl[2.2]paracyclophane (3), which contains a perfluorinated keto group at the aromatic ring, is used to synthesize polymer 4. Furthermore, the keto-functionalized polymer 4 introduces both extreme hydrophobicity and surface reactivity towards hydrazide-containing ligands.

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“…[1-6] Spatial control over ligand presentation and soluble factor release are important features for the realization of biomimicry and recapitulation of complex cell-microenvironment interactions. [7-11] Electropolymerization is ideally suited for this purpose because it is a mild encapsulation procedure that enables high retention of the activity of a labile encapsulated species.…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporal Control over Molecular Delivery and Cellular Encapsulation from Electropolymerized Micro‐ and Nanopatterned Surfaces

Stern

Jay

Demento

et al. 2009

Adv Funct Materials

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Bioactive, patterned micro-and nanoscale surfaces that can be spatially engineered for threedimensional ligand presentation and sustained release of signaling molecules represent a critical advance for the development of next-generation diagnostic and therapeutic devices. Lithography is ideally suited to patterning such surfaces due to its precise, easily scalable, high-throughput nature; however, to date polymers patterned by these techniques have not demonstrated the capacity for sustained release of bioactive agents. We demonstrate here a class of lithographically-defined, electropolymerized polymers with monodisperse micro-and nanopatterned features capable of sustained release of bioactive drugs and proteins. We show that precise control can be achieved over the loading capacity and release rates of encapsulated agents and illustrate this aspect using a fabricated surface releasing a model antigen (ovalbumin) and a cytokine (interleukin-2) for induction of a specific immune response. We further demonstrate the ability of this technique to enable threedimensional control over cellular encapsulation. The efficacy of the described approach is buttressed by its simplicity, versatility, and reproducibility, rendering it ideally suited for biomaterials engineering.

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Reactive Polymer Coatings for Biomimetic Surface Engineering

Cited by 35 publications

References 102 publications

The insulation performance of reactive parylene films in implantable electronic devices

The insulation performance of reactive parylene films in implantable electronic devices

Partially Fluorinated Poly‐p‐xylylenes Synthesized by CVD Polymerization

Spatiotemporal Control over Molecular Delivery and Cellular Encapsulation from Electropolymerized Micro‐ and Nanopatterned Surfaces

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