Reactive thrombocytosis leading to stent thrombosis

Kalantri, Piyush; Kaushik, Aniruddha; Singla, Rahul; Bade, Arun; Bansal, Nalini

doi:10.4103/jpcs.jpcs_31_20

Cited by 1 publication

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“…The thrombotic and hemorrhagic risks associated with primary thrombocytosis ranged from 3.8 to 23.7% and 23.7% to 36% while in secondary thrombocytosis it was ranging from 0 to 14% and 3.03 to 4% respectively [2,[11][12][13][14][15]. Though it is evident from the above studies that the percentage of population developing risks was comparatively lower in the reactive thrombocytosis group when compared to primary thrombocytosis, this needs to be re-explored in the coming days as the number of reports highlighting the risks associated with secondary thrombocytosis are increasing [16][17][18][19][20][21][22][23]. The incidence of thrombotic episodes ranged from 22% to 63% and the incidence of bleeding episodes from 11% to 21% in patients with thrombocythemia [24].…”

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The role of thrombocytapheresis in the management of extreme thrombocytosis: a 6 years’ experience from a tertiary care center

Chenna

Polavarapu

Kandasamy

et al. 2021

Medicine and Pharmacy Reports

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Background. According to the American Society for Apheresis (ASFA) guidelines, thrombocytapheresis is a Category II indication in symptomatic patients and is a Category III indication when used as secondary or prophylactic treatment. The role of thrombocytapheresis is to prevent untoward complications that might occur even before the cytoreductive agents can exert their action. Methods. A retrospective analysis of patients who underwent thrombocytapheresis between 2012 to 2018 was conducted. Demographic details, complete blood counts, diagnosis and indication for thrombocytapheresis were noted. Results. A total of 12 patients with thrombocytosis were included in the study. The cause of thrombocytosis was primary in 3 (25%) patients and secondary in 9 (75%) patients. The average percentage reduction in platelet count was 47.1% (range 12.3%-65.64%). There was a significant decrease in platelet count, platelet crit, and mean platelet volume after the procedure when compared to pre-procedure. Conclusion. Thrombocytapheresis selectively reduces platelet counts with no effect on other cellular and plasma components. The role of thrombocytapheresis in extreme thrombocytosis is to be considered for an immediate decrease in platelet count and to minimize the risks associated with thrombocytosis.

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