Reactive Vascular Lesions Treated Using Ethanolamine Oleate Sclerotherapy

Hong, Soon-Kwon; Lee, Hyun-Jae; Seo, Jong-Keun; Lee, Dong Hoon; Hwang, Seon-Wook; Sung, Ho-Suk

doi:10.1111/j.1524-4725.2010.01599.x

Cited by 20 publications

(23 citation statements)

References 27 publications

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“…In this study, after completion of the treatment schedule, in the long‐term follow up, a statistically significant reduction was observed ( P < 0.05) in the mean ASS and volume of TBE (Tables and ). The local inflammatory properties of the EO injection may explain these results . EO injection was well tolerated by all of the patients with minor side‐effects.…”

Section: Discussionmentioning

confidence: 87%

“…The local inflammatory properties of the EO injection may explain these results. [3][4][5][6][7] EO injection was well tolerated by all of the patients with minor side-effects. These results suggest that EO injection is a safe and effective agent in the treatment of selected IA patients.…”

Section: Discussionmentioning

confidence: 99%

“…EO injection has been used for the treatment of bleeding esophageal varices, varicose veins in the legs, and reactive vascular lesions . The responsible component for the induced inflammation is oleic acid .…”

Section: Introductionmentioning

confidence: 99%

“…EO injection has been used for the treatment of bleeding esophageal varices, varicose veins in the legs, and reactive vascular lesions. [3][4][5] The responsible component for the induced inflammation is oleic acid. 3,6 Our hypothesis is that EO injection in LES causes loss of excitatory neurons in the myenteric plexus by inducing inflammation, damage, and fibrosis of the tissue.…”

Section: Introductionmentioning

confidence: 99%

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Ethanolamine oleate as a novel therapy is effective in resistant idiopathic achalasia

et al. 2013

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Idiopathic achalasia (IA) is a primary motor disorder of the esophagus. Recently, ethanolamine oleate (EO) has been introduced as a novel therapy in IA. We investigate the long-term efficacy of EO injection in the selected IA patients. Two hundred twenty patients with IA were evaluated prospectively. Thirty-one patients who were resistant to or poor candidate of pneumatic balloon dilation and/or cardiomyotomy were enrolled in this study. EO was injected into the lower esophageal sphincter three times at 2-week intervals. Patients were evaluated with the achalasia symptom score (ASS), timed barium esophagogram, and manometry before and after the injections. A good response was defined as a greater than 50% reduction from baseline in the ASS, height and/or volume of barium in TBE, and absence of severe dysphagia or regurgitation at 1.5 months after the last injection. Relapse was defined as two or more points increase in dysphagia score after an initial good response. The mean age of patients was 49.32 ± 19.3 years. Twenty-nine patients had a good response and two had a poor response. The mean ASS decreased from 12.48 (±2.06) to 4.50 (±2.96) (P = 0.0001), and the mean volume of barium decreased from 115.35 (±93.40) to 45.50 (±60.86) mL at 1.5 months after the last injection (P = 0.0001).The mean lower esophageal sphincter pressure was 30.47 ± 13.95 before the treatment and decreased to 14.30 ± 11.89 at 1.5 months after the treatment. (P = 0.0001). The mean duration of follow up was 30.16 ± 11.3 (18-68) months. Twelve patients in whom symptoms relapsed were treated effectively with reinjection. In some patients, minor complications (chest pain and erosion in the distal esophagus) occurred. This study indicates that EO has a long-term effect and can be considered for use in the selected IA patients.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ethanolamine oleate as a novel therapy is effective in resistant idiopathic achalasia

et al. 2013

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“…67 Intralesional Sclerotherapy using intralesional injections of ethanolamine oleate, sodium tetradecyl sulfate, or polidocanol can lead to resolution of PGs but can cause cutaneous necrosis of the surrounding tissue. [68][69][70] Spider Angiomas…”

Section: Topicalmentioning

confidence: 99%

Vascular Skin Lesions in Children: A Review of Laser Surgical and Medical Treatments

Craig

Alster

2013

Dermatologic Surgery

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Vascular anomalies are a common finding in children. Although most of these lesions are benign, they can be a severe cosmetic problem and cause structural and functional damage to nearby tissues. As a result, physicians are tasked with developing effective treatment options with superior safety profiles. Vascular anomalies may be divided into tumors and malformations. Vascular tumors, such as infantile hemangiomas, typically appear a few months after birth, whereas the majority of vascular malformations, such as port-wine stains, are present at birth. Although these lesions vary in appearance, etiology, and disease course, many are treated in a similar fashion. In this review, we focus on treatment modalities for some of the more-prevalent childhood vascular lesions, including port-wine stains, primary telangiectasias, infantile hemangiomas, pyogenic granulomas, and angiomas.

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Oral capillary hemangioma: A clinical protocol of diagnosis and treatment in adults

Silva

Ribeiro

Menezes

et al. 2013

Oral Maxillofac Surg

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Reactive Vascular Lesions Treated Using Ethanolamine Oleate Sclerotherapy

Abstract: EO is an excellent sclerosing agent for treating reactive vascular lesions, and it may be an alternative therapy for vascular lesions in dermatology.

Cited by 20 publications

References 27 publications

Ethanolamine oleate as a novel therapy is effective in resistant idiopathic achalasia

Ethanolamine oleate as a novel therapy is effective in resistant idiopathic achalasia

Vascular Skin Lesions in Children: A Review of Laser Surgical and Medical Treatments

Oral capillary hemangioma: A clinical protocol of diagnosis and treatment in adults

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