Reactivity and Vulnerability to Stress-Associated Risk for Upper Respiratory Illness

Cohen, Sheldon; Hamrick, Natalie; Rodriguez, Mario; Feldman, Pamela J.; Rabin, Bruce S.; Manuck, Stephen B.

doi:10.1097/00006842-200203000-00014

Cited by 98 publications

(62 citation statements)

References 23 publications

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“…Since greater cortisol and blood pressure reactivity to laboratory stress predict certain health risks (e.g., respiratory infections, cardiovascular disease; Cohen et al, 2002;Matthews et al, 2004), it's possible that reduced stress reactivity effects like those observed here may confer some protection against stress-related symptoms and disease risk among stressed adults (cf. Loucks et al, 2015).…”

Section: Discussionmentioning

confidence: 87%

“…A modified version of the Trier Social Stress Test (mTSST; Kirschbaum et al, 1993) was used to manipulate social-evaluative stress reactivity in a controlled laboratory setting. Participants heard pre-recorded instructions (2.5 minutes in length) for the speech performance ("defend yourself against a false shoplifting charge"; Cohen et al, 2002;Franzen et al, 2011) and were given three minutes to mentally prepare for the speech (BP Preparation period). Then, the lights were dimmed for a 20-minute booster training based on condition assignment (BP Training period; see Interventions for additional detail).…”

Section: Methodsmentioning

confidence: 99%

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Acceptance lowers stress reactivity: Dismantling mindfulness training in a randomized controlled trial

Lindsay

Young

Smyth

et al. 2018

Psychoneuroendocrinology

176

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Objective: Mindfulness interventions, which train practitioners to monitor their present-moment experience with a lens of acceptance, are known to buffer stress reactivity. Little is known about the active mechanisms driving these effects. We theorize that acceptance is a critical emotion regulation mechanism underlying mindfulness stress reduction effects. Method:In this three-arm parallel trial, mindfulness components were dismantled into three structurally equivalent 15-lesson smartphone-based interventions: (1) training in both monitoring and acceptance (Monitor+Accept), (2) training in monitoring only (Monitor Only), or (3) active control training (Coping control). 153 stressed adults (mean age = 32 years; 67% female; 53% white, 21.5% black, 21.5% Asian, 4% other race) were randomly assigned to complete one of three interventions. After the intervention, cortisol, blood pressure, and subjective stress reactivity were assessed using a modified Trier Social Stress Test.Results: As predicted, Monitor+Accept training reduced cortisol and systolic blood pressure reactivity compared to Monitor Only and control trainings. Participants in all three conditions reported moderate levels of subjective stress. Conclusions:This study provides the first experimental evidence that brief smartphone mindfulness training can impact stress biology, and that acceptance training drives these effects. We discuss implications for basic and applied research in contemplative science, emotion regulation, stress and coping, health, and clinical interventions.Trial Registration: Clinical Trials NCT02433431

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Section: Discussionmentioning

confidence: 87%

Section: Methodsmentioning

confidence: 99%

Acceptance lowers stress reactivity: Dismantling mindfulness training in a randomized controlled trial

Lindsay

Young

Smyth

et al. 2018

Psychoneuroendocrinology

176

View full text Add to dashboard Cite

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“…This 14-item scale is designed to measure the degree of perceived stress in one's life over the past month. The PSS has demonstrated strong internal reliability and has been found to be associated with physical symptomatology and illness (30)(31)(32)(33)(34)(35). Cronbach's α in the present sample was 0.86.…”

Section: Methodsmentioning

confidence: 60%

“…For example, high levels of stressful life events predicted respiratory illness, but only among those individuals who exhibited high physiological reactivity to a laboratory stressor (i.e. high reactors) (32). Life events did not predict illness among low reactors.…”

Section: Discussionmentioning

confidence: 93%

Perceived Stress is Associated with Impaired T-Cell Response to HPV16 in Women with Cervical Dysplasia

Fang¹,

Miller²,

Bovbjerg³

et al. 2008

ann. behav. med.

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Background-Infection with high-risk subtypes of human papillomavirus (HPV) is a central factor in the development of cervical neoplasia. Cell-mediated immunity against HPV16 plays an important role in the resolution of HPV infection and in controlling cervical disease progression. Research suggests that stress is associated with cervical disease progression, but few studies have examined the biological mechanisms that may be driving this association.

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“…Эти реакции определяются не только характером стрессорных факторов, но и индивидуальными особенностями организма, анализ и взаимосвя-зи которых рассматриваются с позиции нейро-эндокриноиммунологии. В условиях влияния психоэмоциональных стрессоров, в частности в период экзамена, обеспечивается постоянное тесное взаимодействие нейрогенных, эндокрин-ных и иммуногенных посредников, и измене-ние в параметрах функциональной активности одной из регуляторных систем находит свое от-ражение в реакциях других [4,7,13]. Суммарное влияние стрессорных факторов, возникающих в период экзаменационной сессии (эмоциональ-ное напряжение, изменение режима сна, сни-жение двигательной активности), составляют силу и длительность стресса и в целом характе-ризуют его как физиологический или патологи-ческий.…”

Section: широлапов и в пятин вф лавров овunclassified

Features of Immune Reactions in Stress Conditions Associated Associated With Exams

Широлапов¹,

Пятин²,

Лавров³

2014

Med. immunol.

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ОсОбеннОсти иммунОлОгических пОказателей в услОвиях экзаменациОннОгО стрессаШиролапов И.В., Пятин В.Ф., Лавров О.В. ГОУ ВПО «Самарский государственный медицинский университет» Минздравсоцразвития России, г. СамараРезюме. В условиях воздействия психоэмоциональных стрессоров обеспечивается постоянное тесное взаимодействие нервной, эндокринной и иммунной физиологических регуляторных систем. У 203 студентов вуза изучены особенности клеточных и гуморальных показателей системы имму-нитета при экзаменационном стрессе. Установлено снижение абсолютного и относительного со-держания CD3 + Т-лимфоцитов, субпопуляции клеток с функцией естественной цитотоксичности (CD3 -CD16 + CD56 + и CD3 + CD16 + CD56 + клеток) после экзамена по сравнению с таковым до экзаме-на. Выявлено снижение значений CD3 -CD19 + , CD3 + CD4 + и CD3 + CD8 + лимфоцитов после экзамена относительно контрольного периода измерений. Сывороточные концентрации иммуноглобулинов A, M, G находились в пределах физиологических значений нормы. Изменения иммунологических показателей при остром экзаменационном стрессе зависят от особенностей вегетативных и гормо-нальных реакций человека и в определенных условиях -предельных по интенсивности и длительно-сти -психоэмоциональный стресс может вызвать общие нарушения иммунного реагирования. It has been widely accepted that routine psychophysiological stressors may influence immune functioning via their close interactions between nervous, autonomic, endocrine and immune regulatory systems. The aim of this study was to evaluate immune reactions to acute psychophysiological stress in 203 medical students before and after academic exams. The results showed significant decrease of absolute and relative contents CD3 + T cells, natural killer (NK) cell subpopulations and T-NK cells (CD3 -CD16 + CD56 + and CD3 + CD16 + CD56 + ), as well as declined NK cell activity were revealed immediately after exams, as compared to initial values for these indices. Moreover, a significant decrease in CD19 + B cells, CD4 + T-helpers and CD8 + T-cytotoxic lymphocyte counts was found after exams, in comparison with parameters assessed under stress-free conditions, but no differences were observed, when compared with pre-examination values. Serum concentrations of IgA, IgM, IgG were within normal physiological limits. Changes in immunological parameters during acute examination-associated stress depend on characteristics of autonomous and hormonal reactions in humans, and, under particular extreme conditions, such psycho-emotional stress may cause general disturbances of immune reactions. We conclude that acute psycho-physiological stress during the exams causes significant changes in some lymphocyte subpopulations, in particular, natural killers.

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Reactivity and Vulnerability to Stress-Associated Risk for Upper Respiratory Illness

Abstract: Acute HPA and immune responses to laboratory stressors are markers of how vulnerable people are to the increased risk for URI associated with stressors in the natural environment.

Cited by 98 publications

References 23 publications

Acceptance lowers stress reactivity: Dismantling mindfulness training in a randomized controlled trial

Acceptance lowers stress reactivity: Dismantling mindfulness training in a randomized controlled trial

Perceived Stress is Associated with Impaired T-Cell Response to HPV16 in Women with Cervical Dysplasia

Features of Immune Reactions in Stress Conditions Associated Associated With Exams

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