Reactivity of catecholamine-driven Fenton reaction and its relationships with iron(III) speciation

Melín, Victoria; Henríquez, Adolfo; Freer, Juanita; Contreras, David

doi:10.1179/1351000214y.0000000119

Cited by 32 publications

(23 citation statements)

References 39 publications

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“…(b) shows a significant negative association between dopamine levels and the concentration of 8‐oxo‐dG in the caudate from patients with AD ( r s = −0.454, p = 0.026). These data suggest the ability of dopamine in the caudate of AD to enhance the oxidative degradation through Fenton and Fenton‐like reactions (Melin et al ). Additionally, the concentration of dopamine showed a significant positive correlation with VMAT2 expression in the putamen of DLB brains (Fig.…”

Section: Resultsmentioning

confidence: 89%

The interactions of dopamine and oxidative damage in the striatum of patients with neurodegenerative diseases

Yang

Knight

et al. 2019

Journal of Neurochemistry

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The striatum with a number of dopamine containing neurons, receiving projections from the substantia nigra and ventral tegmental area; plays a critical role in neurodegenerative diseases of motor and memory function. Additionally, oxidative damage to nucleic acid may be vital in the development of age-associated neurodegeneration. The metabolism of dopamine is recognized as one of the sources of reactive oxygen species through the Fenton mechanism. The proposed interactions of oxidative insults and dopamine in the striatum during the progression of diseases are the hypotheses of most interest to our study. This study investigated the possibility of significant interactions between these molecules that are involved in the late-stage of Alzheimer's disease (AD), Parkinson disease (PD), Parkinson disease dementia, dementia with Lewy bodies, and controls using ELISA assays, autoradiography, and mRNA in situ hybridization assay. Interestingly, lower DNA/RNA oxidative adducts levels in the caudate and putamen of diseased brains were observed with the exception of an increased DNA oxidative product in the caudate of AD brains. Similar changes were found for dopamine concentration and vesicular monoamine transporter 2 densities. We also found that downstream pre-synaptic dopamine D1 Receptor binding correlated with dopamine loss in Lewy body disease groups, and RNA damage and b-site APP cleaving enzyme 1 in the caudate of AD. This is the first demonstration of region-specific alterations of DNA/RNA oxidative damage which cannot be viewed in isolation, but rather in connection with the interrelationship between different neuronal events; chiefly DNA oxidative adducts and density of vesicular monoamine transporter 2 densities in AD and PD patients.

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Section: Resultsmentioning

confidence: 89%

The interactions of dopamine and oxidative damage in the striatum of patients with neurodegenerative diseases

Yang

Knight

et al. 2019

Journal of Neurochemistry

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“…Several mechanisms have been proposed to relate MF with chemical changes, which occurs within the cells. MF influence the biological systems through biophysical and biochemical interactions such as Fenton and Haber-Weiss reactions, which can finally produce • OH as the most dangerous and cytotoxic free radical 5 , 16 , 42 .…”

Section: Discussionmentioning

confidence: 99%

“…The increase of iron concentration is critical for the production of free radical through Fenton reaction in cells 16 . Low and moderate concentrations of intracellular free radicals contribute to the regulation of homeostasis and critical processes 18 , 19 , while at high concentrations, induce severe stresses such as oxidative damage to DNA, proteins, and membranes 20 , 55 .…”

Section: Discussionmentioning

confidence: 99%

“…Mammalian cells need iron as an essential factor for crucial metabolic functions such as cellular respiration, electron transfer, ATP production, DNA biosynthesis and etc 15 . In addition, iron catalyzes the production of hydroxyl radical ( • OH) and increases ROS generation content through Fenton or Haber-Weiss reaction 16 . Therefore, iron is potentially cytotoxic and can induce oxidative stress and DNA damage in cells 17 .…”

Section: Introductionmentioning

confidence: 99%

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The Static Magnetic Field Remotely Boosts the Efficiency of Doxorubicin through Modulating ROS Behaviors

Hajipour-Verdom

Abdolmaleki

Behmanesh

2018

Sci Rep

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Exposure to magnetic field (MF) can affect cellular metabolism remotely. Cardio-toxic effects of Doxorubicin (DOXO) have limited clinical uses at high dose. MF due to its effect on reactive oxygen species (ROS) lifetime, may provide a suitable choice to boost the efficacy of this drug at low dose. Here, we investigated the potential effects of homogenous static magnetic field (SMF) on DOXO-induced toxicity and proliferation rate of cancer cells. The results indicated that SMF similar to DOXO decreased the cell viability as well as the proliferation rate of MCF-7 and HFF cells. Moreover, combination of 10 mT SMF and 0.1 µM DOXO decreased the viability and proliferation rate of cancer and normal cells in a synergetic manner. In spite of high a GSH level in cancer cell, SMF boosts the generation and lifetime of ROS at low dose of DOXO, and overcame to GSH mediated drug resistance. The results also confirmed that SMF exposure decreased 50% iron content of cells, which is attributed to iron homeostasis. In conclusion, these findings suggest that SMF can decrease required dose of chemotherapy drugs such as DOXO and thereby decrease their side effect.

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“…However, this mechanism of complex formation does not explain the selectivity of the process-neither dopamine nor norepinephrine, both of which also possess the same -OH groups, forms the same complex with Fe 2+ ions. These compounds are capable of creating similar, colorful complexes with Fe 3+ ions [36]. Therefore, another model of the formation of iron-ion complex and epinephrine was proposed, taking into account structural elements present in both epinephrine and isoprenaline structures [37].…”

Section: Ep-fe 2+ Complex Creationmentioning

confidence: 99%

Fluorescence Sensing Platforms for Epinephrine Detection Based on Low Temperature Cofired Ceramics

Baluta

Malecha

Świst

et al. 2020

Sensors

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A novel fluorescence-sensing pathway for epinephrine (EP) detection was investigated. The ceramic-based miniature biosensor was developed through the immobilization of an enzyme (laccase, tyrosinase) on a polymer—poly-(2,6-di([2,2′-bithiophen]-5-yl)-4-(5-hexylthiophen-2-yl)pyridine), based on low temperature cofired ceramics technology (LTCC). The detection procedure was based on the oxidation of the substrate, i.e., in the presence of the enzyme. An alternative enzyme-free system utilized the formation of a colorful complex between Fe2+ ions and epinephrine molecules. With the optimized conditions, the analytical performance illustrated high sensitivity and selectivity in a broad linear range with a detection limit of 0.14–2.10 nM. Moreover, the strategy was successfully used for an EP injection test with labeled pharmacological samples.

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Reactivity of catecholamine-driven Fenton reaction and its relationships with iron(III) speciation

Abstract: The presence of Fe(III) mono-complex is essential in the ability of catecholamines to increase the oxidative capacity of Fenton systems.

Cited by 32 publications

References 39 publications

The interactions of dopamine and oxidative damage in the striatum of patients with neurodegenerative diseases

The interactions of dopamine and oxidative damage in the striatum of patients with neurodegenerative diseases

The Static Magnetic Field Remotely Boosts the Efficiency of Doxorubicin through Modulating ROS Behaviors

Fluorescence Sensing Platforms for Epinephrine Detection Based on Low Temperature Cofired Ceramics

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