Reactivity of Cholesterol and Some Fatty Acids Toward Singlet Oxygen

HIV-1 promoter activation following an oxidative stress mediated by singlet oxygen

“…by irradiation in the presence of a hydrophilic photosensitizer such as RB or with photosensitizers having DNA affinity [47,48]. When 1 O 2 is generated outside cells, its primary target is the membrane where it can initiate lipid peroxidation [49] or protein oxidation at the level of aromatic residues [50]. In a cell-free system, lipid radicals and/or lipid peroxides formed during the propagation step of lipid peroxidation and non-radical products generated by lipid peroxide decomposition can damage DNA [19].…”

Photochemically stimulated drug delivery increases the cytotoxicity and specificity of EGF–saporin

“…Nearly all of the solid matter in cells consists of 4 forms of biomolecules; proteins, nucleic acids, polysaccharides and lipids. Polysaccharides seems not to suffer from photochemical oxidation, while unsaturated fatty acids (Doleiden et al 1974, Bachowski et al 1988, proteins (especially 5 amino acids (histidine, tryptophan, cystein, methionine and tyrosine)) (Jori et al 1969, Jori et al 1971, Doleiden et al 1974, Das et al 1985, Berg & Moan 1988, Berg et al 1990a) and the nucleotide guanine (Gutter et al 1977) are sensitive to PDT-mediated oxidation.…”

Photodynamic Therapy: Current Status and Future Directions

“…The rates of reaction of singlet oxygen with unsaturated fatty acids are in the range of 0.74-2.4 × 10 5 M -1 s -1 and depend on the number of double bonds in the unsaturated fatty acids [65]. An additional factor, which contributes to PDT-induced lipid damage, is the high solubility of oxygen in lipids.…”