Reactivity of Copper(II) Hydroxides and Copper(II) Alkoxides for Cleaving an Activated Phosphate Diester

Young, Mary Jane; Wahnon, Daphne; Hynes, Rosemary C.; Chin, Jik

doi:10.1021/ja00142a010

Cited by 173 publications

(120 citation statements)

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“…The pseudo-first order rate constant of hydrolysis of BDNPP k (s -1 ) was calculated from the slope of the linear plot of ln[a/(a-x)] versus time (t), 28 which a is the initial concentration of BDNPP and x is the concentration of BDNPP at t time.…”

Section: Materials and Instrumentsmentioning

confidence: 99%

DNA-Binding and Cleavage Studies of Zinc(II) Mixed-polypyridyl Complex

2006

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The complex of Zn[(phen)(dione)Cl]ClO 4 •H 2 O (where phen is 1,10-phenanthroline and dione is 1,10-phenanthroline-5,6-dione) has been synthesized and characterized. The interaction of the complex with DNA was investigated using UV absorption, fluorescence spectroscopy and electrophoresis measurements. The results show that the complex mainly binds to the double helix of DNA with intercalation mode and the binding constant K is 2.4×10 4 mol -1 •L. Moreover, the complex can efficiently cleave plasmid DNA at physiological pH and temperature. The cleavage occurs via a hydrolysis mechanism, which is showed by adding radical scavengers, rigorously anaerobic experiments, analysis for malondialdehyde-like products, and the hydrolysis experiment of BDNPP with a rate constant k obs of 5.3×10 -6 s -1 .

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Section: Materials and Instrumentsmentioning

confidence: 99%

DNA-Binding and Cleavage Studies of Zinc(II) Mixed-polypyridyl Complex

2006

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“…[9] Since shorter water oxygenϪcopper bonds always lead to greater acidity, and hence to lower pK a values, [6] the discrepancy in the structure between these two Cu II Ϫmacrocycle complexes may be responsible for the different deprotonation behavior.…”

Section: Resultsmentioning

confidence: 99%

“…[6] The second-order rate constant k cat for Cu 2 L is 0.39  Ϫ1 s Ϫ1 at pH ϭ 9.5 (shown in Figure 4 …”

Section: Hydrolysis Of 4-nitrophenyl Acetatementioning

confidence: 99%

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Carboxy Ester Hydrolysis Promoted by a Dicopper(II) Macrocyclic Polyamine Complex with Hydroxypropyl Pendant Groups

Huang

et al. 2004

Eur J Inorg Chem

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A dinuclear Cu II complex containing a hexaaza macrocyclic ligand bearing two 2-hydroxypropyl pendants, 3,6,9,16,19,22-hexaaza-6,19-bis(2-hydroxypropyl) . The protonation constants of Cu 2 L were determined by potentiometric titration, and it was found that the alcoholic hydroxypropyl group of the complex Cu 2 L exhibits low pK a values of pK a1 = 7.31, pK a2 = 7.83 at 25°C. The hydrolysis kinetics of 4-nitrophenyl acetate (NA) promoted by the title

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“…Recrystallisation of the blue solid obtained from an acetonitrile-methanol solution containing two equivalents of CuBr 2 2ϩ tectons with approximate C 2 -symmetry, Fig. 1 and Table 1.…”

Section: -37mentioning

confidence: 99%

Novel one-dimensional structures and solution behaviour of copper(ii) bromide and chloride complexes of a new pentapyridyldiamine ligandElectronic supplementary information (ESI) available: Table S1: Selected bands from FTIR spectra of solid-state species in KBr disks. Table S2: UV-Vis-NIR spectroscopic data. Fig. S1: Views of the crystal structure of [Cu2(L)Br3]2[Cu2Br4], illustrating: (a) the chains of bromide-bridged [Cu2(L)Br2]2+ tectons and interspersed [Cu2Br4]2? counter ions; (b) the packing of the

et al. 2004

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Copper() bromide and chloride complexes of the new heptadentate ligand 2,6-bis(bis(2-pyridylmethyl)amino)-methylpyridine (L) have been prepared. For the bromide complexes, chains of novel, approximately2ϩ 'wedge-shaped' tectons are found. The links between the dicopper tectons and the overall chirality and packing of the chains are dictated by the bromide ion content, not the counter anion. In contrast, the chloride complexes exhibit linked asymmetric [Cu 2 (L)Cl 3 ] ϩ tectons with distinct N 3 CuCl 2 and N 4 CuCl 2 centres in the solid. The overall structures of the dicopper bromide and chloride units persist in solution irrespective of the halide. The redox chemistry of the various species is also described.

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Reactivity of Copper(II) Hydroxides and Copper(II) Alkoxides for Cleaving an Activated Phosphate Diester

Cited by 173 publications

References 2 publications

DNA-Binding and Cleavage Studies of Zinc(II) Mixed-polypyridyl Complex

DNA-Binding and Cleavage Studies of Zinc(II) Mixed-polypyridyl Complex

Carboxy Ester Hydrolysis Promoted by a Dicopper(II) Macrocyclic Polyamine Complex with Hydroxypropyl Pendant Groups

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