Reactivity of cyanothioformamides and 3‐(4‐bromophenyl)‐5‐imino‐4‐oxazolidinethione toward ortho‐substituted nucleophiles

Synthesis, characterization, and derivatization of some novel types of fluorinated mono- and bis-imidazolidineiminothiones with antitumor, antiviral, antibacterial, and antifungal activities

“…Recent approaches have employed environmentally-friendly N-arylimino-1,2,3-dithiazoles which transform readily to the corresponding cyanothioformanilides under various conditions [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. N-Arylcyanothioformanilides have found wide utility in organic synthesis [11,15,[37][38][39][40][41][42][43] and we have used them to prepare various heterocycles with promising pharmacological properties. Such reagents are ambident nucleophiles as reflected by their existence as tautomeric mixtures [44,45], and thus may react at the sulfur or nitrogen atom.…”

“…ring-closure reactions of N-arylcyanothioformanilides [13,18,42,[46][47][48] to yield various heterocyclic cores which include pyrroles [14,[49][50][51], pyrrolothiazoles [52], imidazoles [10,13,[53][54][55][56][57][58][59][60][61], benzimidazoles [62], oxazoles [11,43,47,48], benzoxazoles [43,47,48,62], thiazoles [52,63], quinazolinonethiones [42,60], quinoxaline [42], imidazoquinoxalines [63,64], among others [65][66][67][68][69][70][71].…”

Syntheses of some novel imidazolidinethiones and condensed imidazoles containing arylazo moieties starting from cyanothioformamides

“…They can also be used as materials for nonlinear optics and for storage of optical information in laser disks [9]. As an extension to our interest [10][11][12][13][14][15][16] on the chemistry of cyanothioformamides 1, we report herein the synthesis of novel imidazolidinethione and condensed imidazole derivatives containing arylazo moieties.…”

Halogenated, alkylated and new types of imidazolidine, pyrrolidine, imidazotriazine and thienoimidazole derivatives with biological and antitumor activities

“…Our interest in the chemistry of cyanothioformamide [12][13][14][15][16] led us to synthesize various types of cyanothioformamides containing aliphatic, aromatic and heterocyclic [17] moieties as well as sulpha derivatives [18]. Various fused heterocycles [19,20] starting from cyanothioformamides were synthesized and comparative studies between the latter and related compounds [21,22] were carried out.…”