Reactivity of cyclic alkoxyguanidines – experimental and theoretical studies

Sączewski, Jarosław; Korcz, Martyna; Karczewska, Patrycja; Gdaniec, Мaria

doi:10.3998/ark.5550190.p008.303

Cited by 6 publications

(1 citation statement)

References 21 publications

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“…Compound 4f crystallizes as isopropanol solvate with one solvent molecule in the asymmetric unit (Figure 3). The bond lengths and angles are within the normal ranges [15] and are comparable to those found in closely related structures 1-(3-chlorophenyl)-3-(1- p -tolylimidazolidin-2-ylidene)urea [16] and 2-(methoxyimino)- N -((4-methyl-phenyl)-sulfonyl)imidazolidine-1-carboxamide monohydrate [17]. The bond length of C7=O8, 1.229(3) Å is characteristic of that for the normal C=O double bond (1.230(7) Å in ureas [15]).…”

Section: Resultssupporting

confidence: 62%

Synthesis, Structural Studies and Molecular Modelling of a Novel Imidazoline Derivative with Antifungal Activity

et al. 2015

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Six novel imidazoline derivatives were synthesized and tested in antifungal assays. One of the compounds, N-cyclohexyl-2-imino-3-(4-nitrophenyl)imidazolidine-1-carboxamide showed moderate activity against several clinical strains of Candida albicans. Its structure was solved by X-ray crystallography and its mode of action was deduced using molecular modelling. It was found to be similar to that of fluconazole. The potential for further optimization including SAR of the compound is briefly discussed.

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