Reactivity of metal–oxo clusters towards biomolecules: from discrete polyoxometalates to metal–organic frameworks

Abstract

Discrete metal-oxo clusters and cluster-based assemblies (namely polyoxometalates and Metal–Organic Frameworks) are promising catalysts for the chemical transformation of various biomolecules, such as proteins, DNA, biomass sugars, and lipids.

Bioorthogonal chemistry of polyoxometalates – challenges and prospects

“…It is clear that the fundamental properties of POMs attracting much attention from scientists working in the fields of catalysis, 39 biomedicine, 18,19,40,41 or electronics 42–45 have their downsides, namely high reactivity and cytotoxicity. 46,47 There is no doubt that the properties of POMs literally contradict the formal criteria for bioorthogonal reagents. 5 However, does this mean that the very idea of implementing bioorthogonal POM chemistry should be abandoned?…”

Ionic liquid-stabilized metal oxoclusters: from design to catalytic application

“…Distinguished by their unique structures and properties, MOCs can be tailored for a wide range of specific applications, including catalysis, 1 materials science, 2–4 and biomedical applications. 5,6 In catalysis, they are able to serve as catalysts in practical processes like the production of fuels and fine chemicals. 7 Moreover, MOCs are under investigation as potential materials for batteries, solar cells, and other electronic devices in materials science.…”