Reactivity of Naphthyridines toward Nitrogen Nucleophiles

Spectral Characteristics of 2,7-Naphthyridines

“…The few complete sets of spectral data found in literature [4,5] were also used in the computation of the tabulated increments. Chemical shift calculations based on suggested formulas can be performed with good accuracy.…”

The first synthesis of furazano[3,4‐b][1,6]naphthyridines

“…Herein, we report the successful synthesis of angularly fused furazano [1,6]naphthyridines using 6-acethyl-7-aminofurazano [3,4-b]pyridine 3 as a precursor.…”

“…Considerable efforts have been directed toward the synthesis of 1.6-naphthyridine derivatives. A number of methods for their preparations have been developed and are well covered in the literature by some excellent reviews [6][7][8][9][10].…”

“…Much greater attention has been directed towards the synthesis of benzo-and pyrido-annelated 1,6-naphthyridine ring systems probably as a consequence of the ready availability of suitable precursors [8][9][10]. At the same time only two azole[h]annelated ring systems have been reported, namely oxazolo [4,5-f] [1,6]naphthyridine [11] and pyrazolo [3,4-h] [1,6]naphthyridine [12][13][14].…”

“…

-acetyl-7-aminofurazano[3,4-b]pyridines with DMFDMA afforded N,N-dimethylformamidines that were cyclized to the novel furazan-fused [1,6]naphthyridine system by treatment with sodium methylate in good yield. The tricyclic system is characterized by X-ray crystallography.

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