Reactivity of Peroxidase Oxidants with Lipids: The Generation of Biologically Important Modified Lipids

Human neutrophils ≠ murine neutrophils: Does it matter?

“…HOCl reacts with a wide variety of biomolecules, including proteins, lipids, carbohydrates, histones, and nucleic acids. [162][163][164][165] With respect to proteins, HOCl reacts most readily with sulfur-containing residues, notably methionine and cysteine, and generates monochloramines (NH 4 Cl), protein chloramines (PNHCl), aldehydes, and other products, some of which exert sustained antimicrobial action [reviewed in 166 ]. It is important to recognize that HOCl does not react preferentially with microbial proteins rather than with host targets; all susceptible substrates are attacked regardless of their origin.…”

“…H 2 O 2 generated by the NADPH oxidase, reacts with MPO to form Compound I (Cpd I), which mediates the two‐electron oxidation of Cl − to Cl + and the production of HOCl. HOCl reacts with a wide variety of biomolecules, including proteins, lipids, carbohydrates, histones, and nucleic acids 162–165 . With respect to proteins, HOCl reacts most readily with sulfur‐containing residues, notably methionine and cysteine, and generates monochloramines (NH 4 Cl), protein chloramines (PNHCl), aldehydes, and other products, some of which exert sustained antimicrobial action [reviewed in 166 ].…”