Reactivity of salivary uric acid in response to social evaluative stress in African Americans

Lucas, Todd; Riis, Jenna L.; Buchalski, Zachary; Drolet, Caroline E.; Dawadi, Anurag

doi:10.1016/j.biopsycho.2020.107882

Cited by 12 publications

(6 citation statements)

References 61 publications

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“…Elevated UA levels were also associated with emotional disorders such as anxiety and mood disorders [39,40]. Brain regions including the prefrontal cortex, amygdala, and hippocampus are responsible for stress reaction and emotion regulation.…”

Section: Clinical Significance Of Salivary Ua Concentrationsmentioning

confidence: 99%

Non-invasive determination of uric acid in human saliva in the diagnosis of serious disorders

Vernerová

Krčmová

Melichar

et al. 2020

Clinical Chemistry and Laboratory Medicine (CCLM)

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This review summarizes and critically evaluates the published approaches and recent trends in sample pre-treatment, as well as both separation and non-separation techniques used for the determination of uric acid (UA) in saliva. UA is the final product of purine nucleotide catabolism in humans. UA concentrations in biological fluids such as serum, plasma, and urine represent an important biomarker of diseases including gout, hyperuricemia, or disorders associated with oxidative stress. Previous studies reported correlation between UA concentrations detected in saliva and in the blood. The interest in UA has been increasing during the past 20 years from a single publication in 2000 to 34 papers in 2019 according to MEDLINE search using term “uric acid in saliva”. The evaluation of salivary UA levels can contribute to non-invasive diagnosis of many serious diseases. Increased salivary UA concentration is associated with cancer, HIV, gout, and hypertension. In contrast, low UA levels are associated with Alzheimer disease, progression of multiple sclerosis, and mild cognitive impairment.

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Section: Clinical Significance Of Salivary Ua Concentrationsmentioning

confidence: 99%

Non-invasive determination of uric acid in human saliva in the diagnosis of serious disorders

Vernerová

Krčmová

Melichar

et al. 2020

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…The external factors can rapidly alter salivary uric acid concentration. Lucas et al reported that acute social stress rose the adults' salivary UA level rapidly and signi cantly 50 . In another study, the cold pain stimulus at 5℃ rose salivary UA level in healthy young adults about half an hour after the stimulation, demonstrating a delayed response to acute physical stress 51 .…”

Section: Salivary Uric Acid Concentration (Ua)mentioning

confidence: 99%

Distinguishable Shot-term Effects of Tea and Water Drinking on Human Saliva Redox

Meng

Chong

Song

et al. 2023

Preprint

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Food consumption can alter the biochemistry and redox status of human saliva, and the serving temperature of food may also play a role. The study aimed to explore the immediate (3 min) and delayed (30 min) effects of hot tea (57±0.5℃) ingestion and cold tea (8±0.5℃) ingestion on the salivary flow rate and salivary redox-relevant attributes. The saliva was collected from 20 healthy adults before, 3-min after and 30-min after the tea ingestion. The hot or cold deionised water at the same temperatures were used as control. The salivary flow rate and redox markers in hot tea (HBT), cold tea (CBT), hot water (HW) and cold water (CW) group wereanalysedand compared. The results demonstrated that neither the black tea nor the water altered the salivary flow rate; the black tea immediately increased the salivary thiol (SH) and malondialdehyde (MDA) content while reduced salivary uric acid (UA) significantly. The tea ingestion showed a tendency to elevate the ferric reducing antioxidant power (FRAP) in saliva, although not significantly. The water ingestion decreased the MDA content immediately and increased the UA level significantly. Cold water was found to induce a greater delayed increase in total salivary total protein (TPC) than the hot water. In conclusion, the black tea ingestion affects the redox attributes of human saliva acutely and significantly, while the temperature of drink makes the secondary contribution.

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“…The number of transporters affects serum uric acid levels to some extent ( 15 ). In addition, URAT1 has been shown to be regulated by α-protein kinase 1 ( 16 ), insulin ( 17 ), and the glucocorticoid receptor ( 18 ), which also partly explains the increased uric acid levels in some patients with diabetes and humans under stress conditions in clinical practice ( 19 ). In the gut, uric acid is converted to ammonia and carbon dioxide.…”

Section: Gout Kidney Injurymentioning

confidence: 99%

Research progress of risk factors and early diagnostic biomarkers of gout-induced renal injury

et al. 2022

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Gout renal injury has an insidious onset, no obvious symptoms, and laboratory abnormalities in the early stages of the disease. The injury is not easily detected, and in many cases, the patients have entered the renal failure stage at the time of diagnosis. Therefore, the detection of gout renal injury–related risk factors and early diagnostic biomarkers of gout renal injury is essential for the prevention and early diagnosis of the disease. This article reviews the research progress in risk factors and early diagnostic biomarkers of gout renal injury.

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Reactivity of salivary uric acid in response to social evaluative stress in African Americans

Cited by 12 publications

References 61 publications

Non-invasive determination of uric acid in human saliva in the diagnosis of serious disorders

Non-invasive determination of uric acid in human saliva in the diagnosis of serious disorders

Distinguishable Shot-term Effects of Tea and Water Drinking on Human Saliva Redox

Research progress of risk factors and early diagnostic biomarkers of gout-induced renal injury

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