Reactivity to autologous serum skintest and clinical features in chronic idiopathic urticaria

Nettis, Eustachio; Dambra, Porzia; D'Oronzio, L; Cavallo, Elsa; Loria, M. P.; Fanelli, Margherita; Ferrannini, A.; Tursi, A.

doi:10.1046/j.0307-6938.2001.00962.x

Cited by 65 publications

(77 citation statements)

References 7 publications

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“…Unlike some investigators [19][20][21], we did not find a significant correlation between elevated TPO and positive ASST or CD63 expression. The finding in the present study is comparable with the study of Nettis et al, who did not detect a statistically significant difference between thyroid antibodies in either ASST positive or negative groups [31].…”

Section: Discussionsupporting

confidence: 82%

See 1 more Smart Citation

Chronic urticaria and thyroid autoimmunity markers

Chomičienė¹,

Jurgauskienė²,

Blažienė³

2012

Open Medicine

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Section: Discussionsupporting

confidence: 82%

“…However, other studies did not support this observation [31]. We also found no correlation between disease activity, duration of disease and CAU markers (ASST, CD63 expression).…”

Section: Tpo-anti-thyroid Peroxidase Antibodies Tsh-thyroid-stimulatcontrasting

confidence: 50%

Chronic urticaria and thyroid autoimmunity markers

Chomičienė¹,

Jurgauskienė²,

Blažienė³

2012

Open Medicine

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“…Other studies have reported the prevalence of positive ASST to vary from 34% to 67%. [6][7][8] There was no significant difference between the two groups for age, gender, and presence of angioedema or history of atopy. These findings correlate well with those previously reported by Kulthanan et al and George et al 9,10 Duration of disease was found to be significantly longer in patients with positive ASST by Sabroe et al and Azim et al 5,11 We also found the duration of disease to be longer in ASST positive group however; this could not reach a statistically significant level.…”

Section: Resultsmentioning

confidence: 87%

Chronic idiopathic urticaria and autoimmunity: frequency and association in patients with positive versus negative autologous serum skin test

2017

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Background: Chronic idiopathic urticaria is a subset of urticaria where no known trigger is identifiable. Almost half of these patients have an autoimmune basis of their disease. Autologous serum skin test (ASST) is an easy to perform test to identify this subgroup. However, frequency and association of positive ASST with other markers of autoimmunity remains to be studied. The present study was aimed to find out the same.Methods: Chronic idiopathic urticaria patients were divided into two groups on the basis of ASST. These were further compared for their clinical characteristics including age, gender, duration of disease and urticaria activity score. Also investigation profile including serum IgE levels, anti TPO antibodies, antiTSH and antinuclear antibodies were compared.Results: There were no statistical differences in the age, gender, duration of disease and urticaria activity score in the ASST positive and negative patients. Serum IgE levels though lower in ASST positive group were not statistically different. Frequencies of AntiTPo antibodies, antiTSH and antinuclear antibodies were also comparable in the two groups.Conclusions: ASST positive and negative groups can’t be distinguished clinically. Also autoimmunity was found to be associated with both ASST positive and negative groups.

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“…15 Nettis et al reported 42 (41.2%) ASST positivity out of 102 CU patients. 16 Whereas, Bakos et al in his study reported a higher percentage of ASST positivity 54.2%.…”

Section: Asst Positivity In Cumentioning

confidence: 87%

“…10,19 There is no statistically significant association between ASST positivity and angioedema (p=0.13) which is similar to previous studies. 4,7,12,16,19 Dermographism and ASST In our study, out of 100 CU patients 33 demonstrated dermographism out of which 21 (63.6%) were ASST positive and 12 (36.4%) were ASST negative. There is statistically significant association between dermographism and ASST positivity (p=0.00).…”

Section: Angioedemamentioning

confidence: 99%

A cross-sectional study on autologous: serum skin test in chronic urticaria in a tertiary care centre

2017

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Background: Urticaria persisting daily for more than six weeks is termed as chronic urticaria. A significant number of them have an autoimmune basis, where ASST is used for detection of chronic autoimmune urticaria (CAU). The aim and objective of the study was to determine the frequency of autoimmunity with ASST in chronic urticaria patients.Methods:This was a hospital based cross sectional study, 100 patients with chronic urticaria fulfilling the inclusion and exclusion criteria were enrolled in the study. Detailed history, physical examination and routine investigations were recorded and ASST was done for all patients.Results:Thirty seven (37%) out of 100 CU patients were ASST positive. Statistical analysis of the clinical variables did not show significant difference between ASST positive and negative patients except for dermographism and mean duration of the disease.Conclusions:ASST is a simple invivo clinical test for detection of basophil histamine releasing activity. Diagnosing CAU is important as these patients may need high doses of anti-histamines, systemic corticosteroids and/or immunomodulatory drugs. Autologous serum therapy itself has a therapeutic role in treatment of CAU patients.

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Reactivity to autologous serum skintest and clinical features in chronic idiopathic urticaria

Cited by 65 publications

References 7 publications

Chronic urticaria and thyroid autoimmunity markers

Chronic urticaria and thyroid autoimmunity markers

Chronic idiopathic urticaria and autoimmunity: frequency and association in patients with positive versus negative autologous serum skin test

A cross-sectional study on autologous: serum skin test in chronic urticaria in a tertiary care centre

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