Reactogenicity and safety assessment of an attenuated nanovaccine against scorpion envenomation: Preclinical study

Mohamed, Faez Amokrane Nait; Nouri, Abdelmounaim; Laraba-Djebari, Fatima

doi:10.1016/j.vaccine.2017.10.028

Cited by 7 publications

(3 citation statements)

References 30 publications

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“…The development of a vaccine-like product could enhance the immune responses to a specific antigen without deleterious side effects caused by adjuvants [136]. It was reported that the Aah venom and its toxic fraction FtoxG50 vaccine nano-formulations present a high immunogenicity, an important immune-protective effect, and a low reactogenicity [137,138].…”

Section: Advanced Scorpion Envenomation Therapiesmentioning

confidence: 99%

Serotherapy against Voltage-Gated Sodium Channel-Targeting α-Toxins from Androctonus Scorpion Venom

Martin‐Eauclaire

Adi-Bessalem

Hammoudi-Triki

et al. 2019

Toxins

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Because of their venom lethality towards mammals, scorpions of the Androctonus genus are considered a critical threat to human health in North Africa. Several decades of exploration have led to a comprehensive inventory of their venom components at chemical, pharmacological, and immunological levels. Typically, these venoms contain selective and high affinity ligands for the voltage-gated sodium (Nav) and potassium (Kv) channels that dictate cellular excitability. In the well-studied Androctonus australis and Androctonus mauretanicus venoms, almost all the lethality in mammals is due to the so-called α-toxins. These peptides commonly delay the fast inactivation process of Nav channels, which leads to increased sodium entry and a subsequent cell membrane depolarization. Markedly, their neutralization by specific antisera has been shown to completely inhibit the venom’s lethal activity, because they are not only the most abundant venom peptide but also the most fatal. However, the structural and antigenic polymorphisms in the α-toxin family pose challenges to the design of efficient serotherapies. In this review, we discuss past and present accomplishments to improve serotherapy against Androctonus scorpion stings.

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Section: Advanced Scorpion Envenomation Therapiesmentioning

confidence: 99%

Serotherapy against Voltage-Gated Sodium Channel-Targeting α-Toxins from Androctonus Scorpion Venom

Martin‐Eauclaire

Adi-Bessalem

Hammoudi-Triki

et al. 2019

Toxins

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“…Therefore, the authors concluded that this effect can maintain constant protection and help prevent the death of patients who suffer bites from this type of scorpion, mainly in the most susceptible areas [ 51 ]. Furthermore, this attenuated venom in AlgNPs was used in preclinical studies in older animals such as rabbits; an effective immunizing response and safety were observed in its administration as a vaccine, while the treatment barely caused reactogenicity [ 49 ].…”

Section: Nanosystems and Nanocarriersmentioning

confidence: 99%

Nanobiotechnology with Therapeutically Relevant Macromolecules from Animal Venoms: Venoms, Toxins, and Antimicrobial Peptides

et al. 2022

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Some diseases of uncontrolled proliferation such as cancer, as well as infectious diseases, are the main cause of death in the world, and their causative agents have rapidly developed resistance to the various existing treatments, making them even more dangerous. Thereby, the discovery of new therapeutic agents is a challenge promoted by the World Health Organization (WHO). Biomacromolecules, isolated or synthesized from a natural template, have therapeutic properties which have not yet been fully studied, and represent an unexplored potential in the search for new drugs. These substances, starting from conglomerates of proteins and other substances such as animal venoms, or from minor substances such as bioactive peptides, help fight diseases or counteract harmful effects. The high effectiveness of these biomacromolecules makes them promising substances for obtaining new drugs; however, their low bioavailability or stability in biological systems is a challenge to be overcome in the coming years with the help of nanotechnology. The objective of this review article is to describe the relationship between the structure and function of biomacromolecules of animal origin that have applications already described using nanotechnology and targeted delivery.

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“…However, as with most nanomedicines, the preparation of nanovaccines is complex, and it is difficult to guarantee the encapsulation efficiency when multiple adjuvants and/or antigens are needed. , In addition, the effects of nanocarriers on biological systems (such as immunogenicity or potential toxicity) also need to be evaluated. , Thus, the clinical applications of nanovaccines are limited. , …”

Section: Introductionmentioning

confidence: 99%

Enhanced Antitumor Immune Responses via a Self-Assembled Carrier-Free Nanovaccine

et al. 2021

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Nanovaccines have emerged as promising agents for cancer immunotherapy. However, insufficient antitumor immunity caused by inefficient antigen/adjuvant loading and complicated preparation processes are the major obstacles that limit their clinical application. Herein, two adjuvants, monophosphatidyl A (MPLA) and CpG ODN, with antigens were designed into a nanovaccine to overcome the above obstacles. This nanovaccine was constructed with adjuvants (without additional materials) through facile self-assembly, which not only ensured a high loading efficacy and desirable safety but also facilitated clinical translation for convenient fabrication. More importantly, the selected adjuvants could achieve a notable immune response through synergistic activation of Toll-like receptor 4 (TLR4) and TLR9 signaling pathways, and the resulting nanovaccine remarkably inhibited the tumor growth and prolonged the survival of tumor-implanted mice. This nanovaccine system provides an effective strategy to construct vaccines for cancer immunotherapy.

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Reactogenicity and safety assessment of an attenuated nanovaccine against scorpion envenomation: Preclinical study

Cited by 7 publications

References 30 publications

Serotherapy against Voltage-Gated Sodium Channel-Targeting α-Toxins from Androctonus Scorpion Venom

Serotherapy against Voltage-Gated Sodium Channel-Targeting α-Toxins from Androctonus Scorpion Venom

Nanobiotechnology with Therapeutically Relevant Macromolecules from Animal Venoms: Venoms, Toxins, and Antimicrobial Peptides

Enhanced Antitumor Immune Responses via a Self-Assembled Carrier-Free Nanovaccine

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